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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2d
d variant
MGI:3579320
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2d/H2d DBA/2 MGI:3630183
ht2
H2b/H2d (C57BL/6 x DBA/2)F1 MGI:3630186
cx3
H2d/H2d
Trap1atm1.1Jvde/Trap1atm1.1Jvde
involves: 129 * BALB/cJ * C57BL/10 * DBA/2 MGI:5310746
cx4
H2d/H2d
Trap1atm1.1Jvde/Y
involves: 129 * BALB/cJ * C57BL/10 * DBA/2 MGI:5310747
cx5
H2d/H2d
Tg(TcraP1.5,TcrbP1.5)29Amsv/0
Trap1atm1.1Jvde/Y
involves: 129 * BALB/cJ * C57BL/10 * DBA/2 MGI:5310748
cx6
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2d/H2d
Ptcratm1Vbo/Ptcratm1Vbo
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807288
cx7
H2d/H2d
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/0
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807291
cx8
H2d/H2d
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * C57BL/6 MGI:3777752
cx9
H2b/H2d
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2 MGI:4353112
cx10
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
involves: BALB/c * C57BL/6 MGI:3783839
cx11
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
involves: BALB/c * C57BL/6 MGI:3809804
cx12
H2b/H2d
Tg(Ins2-E3)1Dvs/0
involves: BALB/c * C57BL/6 * DBA/2J MGI:3785747
cx13
Dh/Dh+
H2d/H2d
NZB.Cg-Dh MGI:3819783


Genotype
MGI:3630183
hm1
Allelic
Composition
H2d/H2d
Genetic
Background
DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in livers of mice, population of extrathymic T cells begins to expand from the acute phase to the recovery phase, more prominently than in B6 mice
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• levels of Ifng and Il4 are lower than in B6 mice with malarial infection
• level of IgM autoantibody is increase to a greater extent than in B6 mice
• when infected with P. yoelii, DBA/2 mice recover more quickly from malaria than C57BL/6 mice; duration of parasitemia is short and of a low degree

hematopoietic system
• in livers of mice, population of extrathymic T cells begins to expand from the acute phase to the recovery phase, more prominently than in B6 mice
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system
• liver injury as estimated by GPT serum levels is lower than in infected B6 mice




Genotype
MGI:3630186
ht2
Allelic
Composition
H2b/H2d
Genetic
Background
(C57BL/6 x DBA/2)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (24 available); any H2 mutation (274 available)
H2d mutation (23 available); any H2 mutation (274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• levels of Ifng and Il4 are lower than in B6 mice with malarial infection
• level of IgM autoantibody is increase to a greater extent than in B6 mice
• recovery from malaria is similar to DBA/2 mice, faster than in B6 mice

hematopoietic system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system
• liver injury as estimated by GPT serum levels is lower than in infected B6 mice




Genotype
MGI:5310746
cx3
Allelic
Composition
H2d/H2d
Trap1atm1.1Jvde/Trap1atm1.1Jvde
Genetic
Background
involves: 129 * BALB/cJ * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (274 available)
Trap1atm1.1Jvde mutation (0 available); any Trap1a mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• mice are fertile




Genotype
MGI:5310747
cx4
Allelic
Composition
H2d/H2d
Trap1atm1.1Jvde/Y
Genetic
Background
involves: 129 * BALB/cJ * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (274 available)
Trap1atm1.1Jvde mutation (0 available); any Trap1a mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit spontaneous rejection of P815 tumors and increased survival compared with wild-type mice

reproductive system
N
• mice are fertile

immune system
• P1A35-43-specific CD8 T lymphocytes exhibit increased functional avidity compared with wild-type cells
• mice exhibit increased immunogenic response towards P1A35-43 compared with wild-type mice

neoplasm
• mice exhibit spontaneous rejection of P815 tumors and increased survival compared with wild-type mice

hematopoietic system
• P1A35-43-specific CD8 T lymphocytes exhibit increased functional avidity compared with wild-type cells




Genotype
MGI:5310748
cx5
Allelic
Composition
H2d/H2d
Tg(TcraP1.5,TcrbP1.5)29Amsv/0
Trap1atm1.1Jvde/Y
Genetic
Background
involves: 129 * BALB/cJ * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (274 available)
Tg(TcraP1.5,TcrbP1.5)29Amsv mutation (0 available)
Trap1atm1.1Jvde mutation (0 available); any Trap1a mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• T lymphocytes expressing the transgene are negatively selected in the thymus and strongly reduced in the periphery

hematopoietic system
• T lymphocytes expressing the transgene are negatively selected in the thymus and strongly reduced in the periphery




Genotype
MGI:3807288
cx6
Allelic
Composition
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2d/H2d
Ptcratm1Vbo/Ptcratm1Vbo
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (274 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (13 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcrd mutation (16 available)
Tcratm1Mom mutation (6 available); any Tcra mutation (92 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

immune system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

endocrine/exocrine glands
• thymocyte numbers are reduced by about 3-fold




Genotype
MGI:3807291
cx7
Allelic
Composition
H2d/H2d
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (274 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (92 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

endocrine/exocrine glands
• thymocyte numbers are reduced by about 3-fold




Genotype
MGI:3777752
cx8
Allelic
Composition
H2d/H2d
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (274 available)
Rag2tm1Fwa mutation (46 available); any Rag2 mutation (93 available)
Tg(TcraN15,TcrbN15)L2Elre mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the majority of T cells in the thymus are arrested at the double positive stage
• single positive T cells are virtually absent
• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background
• mature CD4 T cells are severely reduced in the spleen
• mature CD8 T cells are virtually absent in the spleen

hematopoietic system
• the majority of T cells in the thymus are arrested at the double positive stage
• single positive T cells are virtually absent
• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background
• mature CD4 T cells are severely reduced in the spleen
• mature CD8 T cells are virtually absent in the spleen




Genotype
MGI:4353112
cx9
Allelic
Composition
H2b/H2d
Themistm1Gasc/Themistm1Gasc
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (24 available); any H2 mutation (274 available)
H2d mutation (23 available); any H2 mutation (274 available)
Themistm1Gasc mutation (1 available); any Themis mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice

immune system
• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice




Genotype
MGI:3783839
cx10
Allelic
Composition
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (24 available); any H2 mutation (274 available)
H2d mutation (23 available); any H2 mutation (274 available)
Tg(TcraTcrb)1100Mjb mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3809804
cx11
Allelic
Composition
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (133 available)
Apobec3Rfv3-s mutation (1 available); any Apobec3 mutation (133 available)
H2b mutation (24 available); any H2 mutation (274 available)
H2d mutation (23 available); any H2 mutation (274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls
• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls




Genotype
MGI:3785747
cx12
Allelic
Composition
H2b/H2d
Tg(Ins2-E3)1Dvs/0
Genetic
Background
involves: BALB/c * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (24 available); any H2 mutation (274 available)
H2d mutation (23 available); any H2 mutation (274 available)
Tg(Ins2-E3)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when transferred into BALB/c hosts, but not C57BL/6 hosts, pancreatic islets from H2 survive much longer than non-transgenic pancreatic islets




Genotype
MGI:3819783
cx13
Allelic
Composition
Dh/Dh+
H2d/H2d
Genetic
Background
NZB.Cg-Dh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dh mutation (1 available); any Dh mutation (1 available)
H2d mutation (23 available); any H2 mutation (274 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls
• no differences are found in B cells from mice 7 months of age
• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls
• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts

reproductive system
• approximately 10-15% of males suffer from this
• cryptorchism in some males, infertility in some females, and mounting difficulties due to limb abnormalities all lead to reduced fecundity
• 25% of females are sterile

limbs/digits/tail
• preaxial triphalangy and /or poly-, syn- or oligodactyly of the hindfeet are characteristic of mice carrying the Dh allele

immune system
• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls
• no differences are found in B cells from mice 7 months of age
• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls
• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts
• an absent spleen is characteristic of mice carrying the Dh allele
• at six months of age, the mean IgG2 level is 2.32 mg/ml compared to 4.37 mg/ml in NZB controls
• at one year of age, the mean IgG2 level is 3.70 mg/ml compared to 6.38 mg/ml in NZB controls
• at six months of age, the mean IgG1 level is 1.39 mg/ml compared to 1.84 mg/ml in NZB controls
• at one year of age, the mean IgG1 level is 1.45 mg/ml compared to 2.17 mg/ml in NZB controls
• at three months of age, the mean IgM level is 0.13 mg/ml compared to 0.45 mg/ml in NZB controls
• at six months of age, the mean IgM level is 0.35 mg/ml compared to 0.79 mg/ml in NZB controls
• at one year of age, the mean IgM level is 0.57 mg/ml compared to 1.38 mg/ml in NZB controls
• Background Sensitivity: mice have increased levels of "naturally occurring thymocytotoxic IgM antibodies" (NTA) compared to NZB controls
• Background Sensitivity: 8 of 9 mice at 6 weeks of age have significant levels of NTAs compared to none in a similar sized group of age-matched NZB mice
• Background Sensitivity: at one year of age, all mice have a mean NTA log2titer of 4.5 compared to 60% of NZB controls with detectable amounts of NTA with a mean titer of 2.2
• Background Sensitivity: 100% of animals by 9 months of age have detectable levels of anti-erythrocyte antibodies (i.e. positive Coombs' test)
• Background Sensitivity: while anti-erythrocyte antibodies are characteristic of the NZB strain, there are differences with this mouse strain in the immunoglobulin classes involved
• Background Sensitivity: one year old mice have a four-fold decrease in the serum level of anti-erythrocyte IgM with a corresponding increase in anti-erythrocyte IgG1
• Background Sensitivity: sheep red blood cells injected into 3 but not 9 month old mice have higher levels of agglutinating antibody coating the cells than in NZB controls t
• Background Sensitivity: 30% of mice at 3 months of age and 90% of mice at 9 months of age have detectable levels of anti-polyIpolyC antibodies, which is similar to NZB controls
• Background Sensitivity: 30% of mice at 3 months of age and 90% of mice at 9 months of age have detectable levels of anti-single stranded DNA antibodies, which is similar to NZB controls
• Background Sensitivity: mice develop a glomular disease similar to NZB controls except that there is no evidence of lymphocytic infiltrate, which occurs in 80% of the NZB controls
• thymocytes isolated from these mice at 20 weeks of age are better able to suppress graft versus host disease (GVHD )than controls in an induced form of GVHD caused by transfer with wild-type NZB splenocytes into an irradiated host
• similar suppression of GVHD as controls is observed when thymocytes are isolated from 4 week old mice

renal/urinary system
• Background Sensitivity: mice develop a glomular disease similar to NZB controls except that there is no evidence of lymphocytic infiltrate, which occurs in 80% of the NZB controls

neoplasm
• Background Sensitivity: lymphomas, which occur in 11% of NZB mice by one year of age, are not observed in these mice

endocrine/exocrine glands
• approximately 10-15% of males suffer from this

skeleton
• preaxial triphalangy and /or poly-, syn- or oligodactyly of the hindfeet are characteristic of mice carrying the Dh allele

hematopoietic system
• B cell proliferation to LPS is reduced by about a third at 2 months of age compared to NZB controls
• no differences are found in B cells from mice 7 months of age
• T cell proliferation to PHA is enhanced by a third at 2 months of age compared to NZB controls
• no differences are found at 7 months of age where proliferation of T cells from both groups is reduced 10-fold compared to T cells from their 2-month old counter parts
• an absent spleen is characteristic of mice carrying the Dh allele
• at six months of age, the mean IgG2 level is 2.32 mg/ml compared to 4.37 mg/ml in NZB controls
• at one year of age, the mean IgG2 level is 3.70 mg/ml compared to 6.38 mg/ml in NZB controls
• at six months of age, the mean IgG1 level is 1.39 mg/ml compared to 1.84 mg/ml in NZB controls
• at one year of age, the mean IgG1 level is 1.45 mg/ml compared to 2.17 mg/ml in NZB controls
• at three months of age, the mean IgM level is 0.13 mg/ml compared to 0.45 mg/ml in NZB controls
• at six months of age, the mean IgM level is 0.35 mg/ml compared to 0.79 mg/ml in NZB controls
• at one year of age, the mean IgM level is 0.57 mg/ml compared to 1.38 mg/ml in NZB controls





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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory