Mouse Genome Informatics
hm1
    Park7tm1Shn/Park7tm1Shn
B6.Cg-Park7tm1Shn/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Characterization of Park7tm1Shn/Park7tm1Shn mice

behavior/neurological
• trained mutant mice remain on rotarod longer than trained wild type at 5, 10, and 15 rpm, but 20 rpm and spend less time "distracted" while on the rod


Mouse Genome Informatics
hm2
    Park7tm1Shn/Park7tm1Shn
involves: 129 * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• brain histology reveals no abnormal morphology in substantia nigra, striatum or astrocytes in 24-27 month old mice (J:134518)
• dopaminergic or noradrenergic neuron loss is not detected (J:134518)
• striatal dopamine levels are similar to control (J:134518)
• no inclusions are detected in the substantia nigra or in noradrengeric neurons of the locus coeruleus (J:134518)
• nigral neurons (dopaminergic neurons) exhibited increased action potential frequency in response to dopamine, indicating a much shorter response to dopamine than in wildtype
• long term depression was absent in medium spiny neurons, however long term potentiation and cortically-evoked excitatory postsynaptic potentials were normal
• evoked dopamine overflow in the striatum was reduced, primarily as a result of increased dopamine uptake, however had normal numbers of nigral dopaminergic neurons

behavior/neurological
N
• performance on the rotarod and in acoustic startle response is similar to control (J:134518)
• 18-25 month old mice exhibit decreased horizontal activity in an open field test as compared to controls
• reduced vertical activity and time spent rearing at 3 months of age
• 18-25 month old mice exhibit fewer instances of stereotyped behavior in an open field test as compared to controls
• marked reduction in horizontal activity and the time spent moving and had fewer instances of stereotyped behavior at 3 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 7, Autosomal Recessive Early-Onset; PARK7 606324 J:98436


Mouse Genome Informatics
cx3
    Gpx1tm1Ysh/Gpx1tm1Ysh
Park2tm1Shn/Park2tm1Shn
Park7tm1Shn/Park7tm1Shn

B6.Cg-Park7tm1Shn Gpx1tm1Ysh Park2tm1Shn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• increased latency to fall (rotarod test) observed at 12 and 18 months of age as compared to controls

homeostasis/metabolism
• striatal dopamine levels are significantly elevated at 6, 12 and 18 months of age, however, dopamine turnover is similar to controls
• striatal serotonin levels are increased at 12 months of age, however, serotonin turnover is similar to controls

nervous system
• striatal dopamine levels are significantly elevated at 6, 12 and 18 months of age, however, dopamine turnover is similar to controls


Mouse Genome Informatics
cx4
    Park2tm1Shn/Park2tm1Shn
Park7tm1Shn/Park7tm1Shn

B6.Cg-Park7tm1Shn Park2tm1Shn
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• increased latency to fall (rotarod test) observed at 6, 12, 13, 16 and 18 months of age as compared to controls
• trained mutant mice remain on rotarod longer than trained wild type at all speeds tested (5, 10, 15 and 20 rpm) and spend less time "distracted" while on the rod

homeostasis/metabolism
• striatal serotonin levels are increased at 12 and 18 months of age
• hippocampal serotonin levels are increased in 15 months old mice