Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id4tm1Fsky mutation
(2 available);
any
Id4 mutation
(8 available)
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mortality/aging
skeleton
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• mice did not exhibit skeletal deformities
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• the sixth lumbar vertebrae exhibits decreased bone volume compared with wild-type mice
• osteoid thickness in the lateral calvarial bone is reduced compared to in wild-type mice
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• the number of two II osteoblast is decreased while the number of type IV osteoblasts is increased compared to in wild-type mice
• however, the total number of ostoblasts is normal
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• the growth plate width and longitudinal growth rate is decreased compared to in wild-type mice
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• mineral apposition rate of the calvaria bone is reduced compared to in wild-type mice
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• lumbar and calvaria bones exhibit reduced bone formation to bone surface ratio compared with wild-type mice
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adipose tissue
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• the number of adipocytes in the epiphyseal tibia bone marrow is increased compared to in wild-type mice
• the number of adipocytes in the lateral calvaria bone is increased compared to in wild-type mice
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growth/size/body
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id4tm1Fsky mutation
(2 available);
any
Id4 mutation
(8 available)
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mortality/aging
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• many of the surviving homozygotes lose weight rapidly after weaning and die, with only 20% surviving to adulthood
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• about 50% of homozygotes die before weaning
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nervous system
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• formation of neurospheres from cells isolated from the E14.5 telencephalon or the adult ventricular/subventricular zone is delayed and proliferation of these cells is reduced by about 20% and 50%, respectively
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• an increase in early born neurons and a decrease in late born neurons is seen in the neocortex and basal ganglia
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• the total number of mitotic nuclei along the apical surface of the neocortex, and the lateral and medial ganglionic eminences is decreased by about 20% and 30% at E12.5 and E14.5, respectively
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• the ventricular zone of the future hippocampus is reduced by about 25% at E12.5 and E14.5
• the total number of mitotic nuclei along the apical surface of the future hippocampus is reduced by about 20% and 30% at E12.5 and E14.5, respectively
• at E12.5 the number of apoptotic cells is significantly increased 1.8-fold in the future hippocampus
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• at 4 and 6 months of age overall brain size is reduced with derivatives of the dorsal telencephalon as well as the thalamus and colliculus appearing smaller
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• the lateral ventricles are reduced at E12.5 and E14.5; however in 4 and 6 month old mutants the lateral ventricles are enlarged
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• at E12.5 and E14.5 the subpallial sulcus separating the basal ganglia is less pronounced reducing the ventricular zones of the lateral and medial ganglionic eminences by about 25%
• at E12.5 the number of apoptotic cells is significantly increased in the ventricular zones of the lateral and medial ganglionic eminences 3.5-fold and 2.5-fold, respectively
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• the ventricular zone of the neocortex is reduced by about 25% at E12.5 and E14.5
• the neocortex also appears slightly thicker at E12.5 and E14.5
• at E12.5 the number of apoptotic cells is significantly increased 1.8-fold in the neocortex
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• layer I is slightly thicker, layer VI is significantly enlarged by about 25%, and layers IV and II/II are reduced by about 35% and 15%, respectively
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• the density of astrocytes in the cortex, septum, and caudate putamen are reduced by about 25%, 33%, and 18%, respectively
• the density of glial fibrillary acidic protien positive astrocytes is reduced in the dentate gyrus, CA2 and CA3 areas of the hippocampus, thalamus, and colliculus
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• the total number of mitotic nuclei along the lateral and medial ganglionic eminences is decreased by about 20% and 30% at E12.5 and E14.5, respectively
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• the total number of mitotic nuclei along the lateral and medial ganglionic eminences is decreased by about 20% and 30% at E12.5 and E14.5, respectively
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growth/size/body
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• about 30% of surviving homozygotes rapidly lose weight after weaning
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cellular
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• formation of neurospheres from cells isolated from the E14.5 telencephalon or the adult ventricular/subventricular zone is delayed and proliferation of these cells is reduced by about 20% and 50%, respectively
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• an increase in early born neurons and a decrease in late born neurons is seen in the neocortex and basal ganglia
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Analysis Tools