Mouse Genome Informatics
hm1
    Id4tm1Fsky/Id4tm1Fsky
involves: 129P2/OlaHsd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die by 5 weeks

skeleton
N
• mice did not exhibit skeletal deformities (J:162236)
• the sixth lumbar vertebrae exhibits decreased bone volume compared with wild-type mice
• osteoid thickness in the lateral calvarial bone is reduced compared to in wild-type mice
• the number of two II osteoblast is decreased while the number of type IV osteoblasts is increased compared to in wild-type mice
• however, the total number of ostoblasts is normal
• the growth plate width and longitudinal growth rate is decreased compared to in wild-type mice
• lumbar and calvaria bones exhibit reduced bone formation to bone surface ratio compared with wild-type mice
• mineral apposition rate of the calvaria bone is reduced compared to in wild-type mice

adipose tissue
• the number of adipocytes in the epiphyseal tibia bone marrow is increased compared to in wild-type mice
• the number of adipocytes in the lateral calvaria bone is increased compared to in wild-type mice

growth/size/body

Mouse Models of Human Disease
OMIM IDRef(s)
Osteoporosis 166710 J:162236


Mouse Genome Informatics
hm2
    Id4tm1Fsky/Id4tm1Fsky
involves: 129P2/OlaHsd * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• about 50% of homozygotes die before weaning
• many of the surviving homozygotes lose weight rapidly after weaning and die, with only 20% surviving to adulthood

nervous system
• formation of neurospheres from cells isolated from the E14.5 telencephalon or the adult ventricular/subventricular zone is delayed and proliferation of these cells is reduced by about 20% and 50%, respectively
• an increase in early born neurons and a decrease in late born neurons is seen in the neocortex and basal ganglia
• the total number of mitotic nuclei along the apical surface of the neocortex, and the lateral and medial ganglionic eminences is decreased by about 20% and 30% at E12.5 and E14.5, respectively
• the ventricular zone of the future hippocampus is reduced by about 25% at E12.5 and E14.5
• the total number of mitotic nuclei along the apical surface of the future hippocampus is reduced by about 20% and 30% at E12.5 and E14.5, respectively
• at E12.5 the number of apoptotic cells is significantly increased 1.8-fold in the future hippocampus
• at 4 and 6 months of age overall brain size is reduced with derivatives of the dorsal telencephalon as well as the thalamus and colliculus appearing smaller
• the lateral ventricles are reduced at E12.5 and E14.5; however in 4 and 6 month old mutants the lateral ventricles are enlarged
• at E12.5 and E14.5 the subpallial sulcus separating the basal ganglia is less pronounced reducing the ventricular zones of the lateral and medial ganglionic eminences by about 25%
• at E12.5 the number of apoptotic cells is significantly increased in the ventricular zones of the lateral and medial ganglionic eminences 3.5-fold and 2.5-fold, respectively
• the ventricular zone of the neocortex is reduced by about 25% at E12.5 and E14.5
• the neocortex also appears slightly thicker at E12.5 and E14.5
• at E12.5 the number of apoptotic cells is significantly increased 1.8-fold in the neocortex
• layer I is slightly thicker, layer VI is significantly enlarged by about 25%, and layers IV and II/II are reduced by about 35% and 15%, respectively
• the density of astrocytes in the cortex, septum, and caudate putamen are reduced by about 25%, 33%, and 18%, respectively
• the density of glial fibrillary acidic protien positive astrocytes is reduced in the dentate gyrus, CA2 and CA3 areas of the hippocampus, thalamus, and colliculus
• the total number of mitotic nuclei along the lateral and medial ganglionic eminences is decreased by about 20% and 30% at E12.5 and E14.5, respectively
• the total number of mitotic nuclei along the lateral and medial ganglionic eminences is decreased by about 20% and 30% at E12.5 and E14.5, respectively

growth/size/body
• about 30% of surviving homozygotes rapidly lose weight after weaning

cellular
• formation of neurospheres from cells isolated from the E14.5 telencephalon or the adult ventricular/subventricular zone is delayed and proliferation of these cells is reduced by about 20% and 50%, respectively
• an increase in early born neurons and a decrease in late born neurons is seen in the neocortex and basal ganglia