Phenotypes associated with this allele
Allelic Composition |
Irf8myls/Irf8myls
|
|
Genetic Background |
involves: BALB/cJ * BXH2/TyJ-Irf8myls |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation
(1 available);
any
Irf8 mutation
(32 available)
|
|
|
immune system
|
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
|
hematopoietic system
|
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
|
growth/size/body
Allelic Composition |
Irf8myls/Irf8+
|
|
Genetic Background |
involves: BXH2/TyJ * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation
(1 available);
any
Irf8 mutation
(32 available)
|
|
|
immune system
hematopoietic system
mortality/aging
|
• die within 10 months of age
|
immune system
|
• develop splenomegaly as early as 6 weeks of age
|
|
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
|
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• splenocytes did not secrete IFN-gamma in response to LPS treatment
|
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• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma
|
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• increased susceptibility to Mycobacterium bovis (BCG) infection
|
neoplasm
|
• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
|
hematopoietic system
|
• develop splenomegaly as early as 6 weeks of age
|
|
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
|
growth/size/body
|
• develop splenomegaly as early as 6 weeks of age
|
mortality/aging
|
• die within 10 months of age
|
neoplasm
immune system
|
• increased susceptibility to Mycobacterium bovis (BCG) infection
|
immune system
|
• increased susceptibility to Mycobacterium bovis (BCG) infection
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation
(1 available);
any
Irf8 mutation
(32 available)
Slc11a1s mutation
(0 available);
any
Slc11a1 mutation
(40 available)
|
|
|
immune system
|
• increased susceptibility to Mycobacterium bovis (BCG) infection
|
immune system
|
• increased susceptibility to Mycobacterium bovis (BCG) infection
|
hematopoietic system
growth/size/body
immune system
|
• increased susceptibility to Mycobacterium bovis (BCG) infection
|
immune system
|
• increased susceptibility to Mycobacterium bovis (BCG) infection
|