About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Irf8myls
myeloproliferative syndrome
MGI:3578920
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Irf8myls/Irf8myls involves: BALB/cJ * BXH2/TyJ-Irf8myls MGI:3578959
ht2
Irf8myls/Irf8+ involves: BXH2/TyJ * C57BL/6 MGI:4939596
cx3
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
BXH2/TyJ MGI:3578951
cx4
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: A/J * BXH2/TyJ MGI:3578958
cx5
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BALB/cJ * BXH2/TyJ MGI:3578955
cx6
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BALB/cJ * BXH2/TyJ MGI:3578956
cx7
Irf8myls/Irf8myls
Slc11a1s/Slc11a1s
involves: BALB/cJ * BXH2/TyJ MGI:3578954
cx8
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C3H/HeJ MGI:3578957
cx9
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C57BL/6J MGI:3578953
cx10
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BXH2/TyJ * C57BL/6J MGI:3578952


Genotype
MGI:3578959
hm1
Allelic
Composition
Irf8myls/Irf8myls
Genetic
Background
involves: BALB/cJ * BXH2/TyJ-Irf8myls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

growth/size/body




Genotype
MGI:4939596
ht2
Allelic
Composition
Irf8myls/Irf8+
Genetic
Background
involves: BXH2/TyJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3578951
cx3
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 10 months of age

immune system
• develop splenomegaly as early as 6 weeks of age
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• splenocytes did not secrete IFN-gamma in response to LPS treatment
• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma
• increased susceptibility to Mycobacterium bovis (BCG) infection

neoplasm
• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• develop splenomegaly as early as 6 weeks of age
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

growth/size/body
• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial chronic myelocytic leukemia-like syndrome DOID:0060761 OMIM:600080
J:97931




Genotype
MGI:3578958
cx4
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: A/J * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 10 months of age

neoplasm

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
familial chronic myelocytic leukemia-like syndrome DOID:0060761 OMIM:600080
J:97931




Genotype
MGI:3578955
cx5
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (40 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578956
cx6
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578954
cx7
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1s/Slc11a1s
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578957
cx8
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BXH2/TyJ * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection

hematopoietic system

growth/size/body




Genotype
MGI:3578953
cx9
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BXH2/TyJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578952
cx10
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
Genetic
Background
involves: BXH2/TyJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (1 available); any Irf8 mutation (32 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (40 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (40 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory