Mouse Genome Informatics
hm1
    Irf8myls/Irf8myls
involves: BALB/cJ * BXH2/TyJ-Irf8myls
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen


Mouse Genome Informatics
ht2
    Irf8myls/Irf8+
involves: BXH2/TyJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system

hematopoietic system


Mouse Genome Informatics
cx3
    Irf8myls/Irf8myls
Slc11a1r/Slc11a1r

BXH2/TyJ-Irf8myls
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• die within 10 months of age

immune system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age
• splenocytes did not secrete IFN-gamma in response to LPS treatment
• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma
• increased susceptibility to Mycobacterium bovis (BCG) infection

tumorigenesis
• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Myelocytic Leukemia-Like Syndrome, Familial, Chronic 600080 J:97931


Mouse Genome Informatics
cx4
    Irf8myls/Irf8myls
Slc11a1r/Slc11a1r

involves: A/J * BXH2/TyJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• die within 10 months of age

tumorigenesis

Mouse Models of Human Disease
OMIM IDRef(s)
Myelocytic Leukemia-Like Syndrome, Familial, Chronic 600080 J:97931


Mouse Genome Informatics
cx5
    Irf8myls/Irf8myls
Slc11a1s/Slc11a1s

involves: BALB/cJ * BXH2/TyJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection


Mouse Genome Informatics
cx6
    Irf8myls/Irf8myls
Slc11a1r/Slc11a1s

involves: BALB/cJ * BXH2/TyJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection


Mouse Genome Informatics
cx7
    Irf8myls/Irf8myls
Slc11a1r/Slc11a1r

involves: BALB/cJ * BXH2/TyJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection


Mouse Genome Informatics
cx8
    Irf8myls/Irf8myls
Slc11a1r/Slc11a1r

involves: BXH2/TyJ * C3H/HeJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection

hematopoietic system


Mouse Genome Informatics
cx9
    Irf8myls/Irf8myls
Slc11a1r/Slc11a1s

involves: BXH2/TyJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection


Mouse Genome Informatics
cx10
    Irf8myls/Irf8myls
Slc11a1r/Slc11a1r

involves: BXH2/TyJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection