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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Irf8myls
myeloproliferative syndrome
MGI:3578920
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Irf8myls/Irf8myls involves: BALB/cJ * BXH2/TyJ-Irf8myls MGI:3578959
ht2
Irf8myls/Irf8+ involves: BXH2/TyJ * C57BL/6 MGI:4939596
cx3
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
BXH2/TyJ-Irf8myls MGI:3578951
cx4
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: A/J * BXH2/TyJ MGI:3578958
cx5
Irf8myls/Irf8myls
Slc11a1s/Slc11a1s
involves: BALB/cJ * BXH2/TyJ MGI:3578954
cx6
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BALB/cJ * BXH2/TyJ MGI:3578955
cx7
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BALB/cJ * BXH2/TyJ MGI:3578956
cx8
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C3H/HeJ MGI:3578957
cx9
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
involves: BXH2/TyJ * C57BL/6J MGI:3578952
cx10
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
involves: BXH2/TyJ * C57BL/6J MGI:3578953


Genotype
MGI:3578959
hm1
Allelic
Composition
Irf8myls/Irf8myls
Genetic
Background
involves: BALB/cJ * BXH2/TyJ-Irf8myls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen




Genotype
MGI:4939596
ht2
Allelic
Composition
Irf8myls/Irf8+
Genetic
Background
involves: BXH2/TyJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3578951
cx3
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
BXH2/TyJ-Irf8myls
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 10 months of age

immune system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age
• splenocytes did not secrete IFN-gamma in response to LPS treatment
• splenocytes did not secrete IL-12 in response to LPS/IFN-gamma
• increased susceptibility to Mycobacterium bovis (BCG) infection

neoplasm
• develop fatal leukemia, characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen

hematopoietic system
• exhibited myeloproliferation characterized by infiltration of Mac1+/Gr1+ granulocyte precursors into the lymph nodes, bone marrow and spleen
• develop splenomegaly as early as 6 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelocytic Leukemia-Like Syndrome, Familial, Chronic 600080 J:97931




Genotype
MGI:3578958
cx4
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: A/J * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within 10 months of age

neoplasm

Mouse Models of Human Disease
OMIM ID Ref(s)
Myelocytic Leukemia-Like Syndrome, Familial, Chronic 600080 J:97931




Genotype
MGI:3578954
cx5
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1s/Slc11a1s
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578955
cx6
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (13 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578956
cx7
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BALB/cJ * BXH2/TyJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578957
cx8
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BXH2/TyJ * C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection

hematopoietic system




Genotype
MGI:3578952
cx9
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1s
Genetic
Background
involves: BXH2/TyJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (13 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection




Genotype
MGI:3578953
cx10
Allelic
Composition
Irf8myls/Irf8myls
Slc11a1r/Slc11a1r
Genetic
Background
involves: BXH2/TyJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irf8myls mutation (0 available); any Irf8 mutation (15 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased susceptibility to Mycobacterium bovis (BCG) infection





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory