All Phenotypes Spry2<tm1.1Mrt> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spry2^tm1.1Mrt/Spry2^tm1.1Mrt	involves: 129P2/OlaHsd	MGI:3702557
hm2	Spry2^tm1.1Mrt/Spry2^tm1.1Mrt	involves: 129/Sv * 129P2/OlaHsd * Black Swiss * C57BL/6 * FVB/N	MGI:3581224
cn3	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467304
cn4	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5467305
cn5	Kras^tm4Tyj/Kras⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt Meox2^tm1(cre)Sor/Meox2⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:3716399
cx6	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J	MGI:3759579
cx7	Spry2^tm1.1Mrt/Spry2^tm1.1Mrt Spry4^tm1.2Mrt/Spry4⁺	involves: 129P2/OlaHsd	MGI:7309963
cx8	Spry2^tm1.1Mrt/Spry2⁺ Spry4^tm1.2Mrt/Spry4^tm1.2Mrt	involves: 129P2/OlaHsd	MGI:6209558
cx9	Fgfr1^tm1.1Jpa/Fgfr1⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3702559
cx10	Fgfr2^tm1.1Dor/Fgfr2⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:3702560

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial bone morphology ( J:315670 )

• all craniofacial bones are thinner compared to wild-type controls

• density of craniofacial bones is reduced as early as E18.5

wide intermaxillary suture ( J:315670 )

• enlarged intermaxillary spaces or extended sutures at 9 weeks of age

increased cranium height ( J:315670 )

• higher cranial vault

abnormal neurocranium morphology ( J:315670 )

• more rounded skull with a higher cranial vault

• skull centroid sizes become more similar to wild-type controls with age suggesting a delay in ontogenetic development

enlarged frontal bone ( J:315670 )

• relatively longer, appearing to compensate for decreased length of the nasal and supraoccipital bones

enlarged interparietal bone ( J:315670 )

• relatively longer, appearing to compensate for decreased length of the nasal and supraoccipital bones

small supraoccipital bone ( J:315670 )

• relatively shorter compared to wild-type controls

abnormal temporal bone morphology ( J:315670 )

• lack the opening normally seen in the temporal bone

small neurocranium ( J:315670 )

• decrease in the length of individual bones in the skull vault

abnormal diastema morphology ( J:119280 )

• rather than regressing as in wild-type mice, diastema tooth buds survive

• thinning is especially evident in suture forming areas

abnormal tooth morphology ( J:315670 )

• an ectopic tooth is found rostrally of the first molar in the mandibular diastema region or the first molar is expanded with a rostral ectopic cusp

abnormal molar cusp morphology ( J:119280 )

• on the anterior end of M1, the cusps are farther apart resulting in shortening of M1

• however, other molar cups are essentially normal, unlike in other mice with supernumerary teeth

abnormal tooth development ( J:119280 )

• rather than regressing as in wild-type mice, diastema tooth buds survive

supernumerary teeth ( J:119280 , J:315670 )

• in the mandible 92% of mice have bilateral diastema teeth, 5% unilateral and 3% no diastema teeth (J:119280)

• less than 5% of mice have supernumerary teeth in the maxilla (J:119280)

• rudimentary tooth bud is present at E14.5 in the diastemal area in the mandible (J:315670)

malocclusion ( J:315670 )

• mandibular and maxillary molars do not properly occlude

abnormal mandible morphology ( J:315670 )

• abnormally shaped mandibular notches

• mandibles tend to have longer toothrow, longer and backward shifted processus coronoideus, slightly shorter incisors, and shortened angular process compared to wild-type controls

abnormal mandibular condyloid process morphology ( J:315670 )

• abnormally shaped

• irregular articular cartilage surfaces throughout the condyle

abnormal mandibular coronoid process morphology ( J:315670 )

• abnormally shaped

abnormal maxillary shelf morphology ( J:315670 )

• vomeronasal bones display posterior curvature that prevents formation of the vomeromaxillary suture within the palatine process of the maxilla

short nasal bone ( J:315670 )

• relatively shorter nasal bone compared to wild-type controls

cleft palate ( J:315670 )

• complete and incomplete cleft palates are seen

complete cleft palate ( J:315670 )

short snout ( J:315670 )

cellular

abnormal primary cilium morphology ( J:315670 )

• axoneme elongation is seen in postnatal but not prenatal tibial and mandibular condyle chondrocytes

digestive/alimentary system

abnormal maxillary shelf morphology ( J:315670 )

• vomeronasal bones display posterior curvature that prevents formation of the vomeromaxillary suture within the palatine process of the maxilla

cleft palate ( J:315670 )

• complete and incomplete cleft palates are seen

complete cleft palate ( J:315670 )

skeleton

abnormal craniofacial bone morphology ( J:315670 )

• all craniofacial bones are thinner compared to wild-type controls

• density of craniofacial bones is reduced as early as E18.5

wide intermaxillary suture ( J:315670 )

• enlarged intermaxillary spaces or extended sutures at 9 weeks of age

increased cranium height ( J:315670 )

• higher cranial vault

abnormal neurocranium morphology ( J:315670 )

• more rounded skull with a higher cranial vault

• skull centroid sizes become more similar to wild-type controls with age suggesting a delay in ontogenetic development

enlarged frontal bone ( J:315670 )

• relatively longer, appearing to compensate for decreased length of the nasal and supraoccipital bones

enlarged interparietal bone ( J:315670 )

• relatively longer, appearing to compensate for decreased length of the nasal and supraoccipital bones

small supraoccipital bone ( J:315670 )

• relatively shorter compared to wild-type controls

abnormal temporal bone morphology ( J:315670 )

• lack the opening normally seen in the temporal bone

small neurocranium ( J:315670 )

• decrease in the length of individual bones in the skull vault

abnormal diastema morphology ( J:119280 )

• rather than regressing as in wild-type mice, diastema tooth buds survive

• thinning is especially evident in suture forming areas

abnormal tooth morphology ( J:315670 )

• an ectopic tooth is found rostrally of the first molar in the mandibular diastema region or the first molar is expanded with a rostral ectopic cusp

abnormal molar cusp morphology ( J:119280 )

• on the anterior end of M1, the cusps are farther apart resulting in shortening of M1

• however, other molar cups are essentially normal, unlike in other mice with supernumerary teeth

abnormal tooth development ( J:119280 )

• rather than regressing as in wild-type mice, diastema tooth buds survive

supernumerary teeth ( J:119280 , J:315670 )

• in the mandible 92% of mice have bilateral diastema teeth, 5% unilateral and 3% no diastema teeth (J:119280)

• less than 5% of mice have supernumerary teeth in the maxilla (J:119280)

• rudimentary tooth bud is present at E14.5 in the diastemal area in the mandible (J:315670)

malocclusion ( J:315670 )

• mandibular and maxillary molars do not properly occlude

abnormal mandible morphology ( J:315670 )

• abnormally shaped mandibular notches

• mandibles tend to have longer toothrow, longer and backward shifted processus coronoideus, slightly shorter incisors, and shortened angular process compared to wild-type controls

abnormal mandibular condyloid process morphology ( J:315670 )

• abnormally shaped

• irregular articular cartilage surfaces throughout the condyle

abnormal mandibular coronoid process morphology ( J:315670 )

• abnormally shaped

abnormal maxillary shelf morphology ( J:315670 )

• vomeronasal bones display posterior curvature that prevents formation of the vomeromaxillary suture within the palatine process of the maxilla

short nasal bone ( J:315670 )

• relatively shorter nasal bone compared to wild-type controls

increased long bone epiphyseal plate size ( J:315670 )

• in the tibia the growth plate is extended compared to wild-type controls

decreased length of long bones ( J:315670 )

abnormal vertebral arch morphology ( J:315670 )

• reduced in size

• bone thickness is reduced in all areas along the vertebral column

abnormal vertebral spinous process morphology ( J:315670 )

• reduced size is especially noticeable in the vertebral processes and most pronounced in the processus spinosus

abnormal vertebral transverse process morphology ( J:315670 )

• the transverse process of the atlas/axis is not fully formed and the transverse foramen is not closed at the caudal aspect in some cases

small vertebral body ( J:315670 )

• reduced in size

• bone thickness is reduced in all areas of the vertebral column

spinal stenosis ( J:315670 )

• spinal stenosis

decreased bone mineral density ( J:315670 )

• density of craniofacial bones is reduced as early as E18.5

decreased trabecular bone mass ( J:315670 )

abnormal chondrocyte morphology ( J:315670 )

• axoneme elongation is seen in primary cilia of postnatal but not prenatal tibial and mandibular condyle chondrocytes

growth/size/body

abnormal tooth morphology ( J:315670 )

• an ectopic tooth is found rostrally of the first molar in the mandibular diastema region or the first molar is expanded with a rostral ectopic cusp

abnormal molar cusp morphology ( J:119280 )

• on the anterior end of M1, the cusps are farther apart resulting in shortening of M1

• however, other molar cups are essentially normal, unlike in other mice with supernumerary teeth

abnormal tooth development ( J:119280 )

• rather than regressing as in wild-type mice, diastema tooth buds survive

supernumerary teeth ( J:119280 , J:315670 )

• in the mandible 92% of mice have bilateral diastema teeth, 5% unilateral and 3% no diastema teeth (J:119280)

• less than 5% of mice have supernumerary teeth in the maxilla (J:119280)

• rudimentary tooth bud is present at E14.5 in the diastemal area in the mandible (J:315670)

malocclusion ( J:315670 )

• mandibular and maxillary molars do not properly occlude

abnormal maxillary shelf morphology ( J:315670 )

• vomeronasal bones display posterior curvature that prevents formation of the vomeromaxillary suture within the palatine process of the maxilla

short nasal bone ( J:315670 )

• relatively shorter nasal bone compared to wild-type controls

cleft palate ( J:315670 )

• complete and incomplete cleft palates are seen

complete cleft palate ( J:315670 )

short snout ( J:315670 )

respiratory system

short nasal bone ( J:315670 )

• relatively shorter nasal bone compared to wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ciliopathy		DOID:0060340		J:315670

Allelic Composition	Spry2^tm1.1Mrt/Spry2^tm1.1Mrt
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * Black Swiss * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:98303 )

• almost half of the homozygous null mice died by weaning

hearing/vestibular/ear

abnormal Claudius cell morphology ( J:98303 )

• multiple regions with more supporting Claudius' cells at P0-P5

abnormal organ of Corti morphology ( J:98303 )

increased cochlear outer hair cell number ( J:98303 )

• extra outer hair cells found in patches alternating with regions containing the normal three rows at P0-P5

abnormal organ of Corti supporting cell morphology ( J:98303 )

increased Deiters cell number ( J:98303 )

• extra Deiters' supporting cell underlying the extra outer hair cell at P0-P5

abnormal pillar cell morphology ( J:98303 )

• had an ectopic third pillar cell at P5-P10 but not at P0-P5, resulting in the formation of an aberrant, second tunnel of Corti-like space between it and the normal outer pillar cell

abnormal auditory brainstem response waveform shape ( J:98303 )

• absence of a wave in response in ABR test

increased or absent threshold for auditory brainstem response ( J:98303 )

• auditory brainstem response (ABR) tests showed that homozygous null mice have intermediate to severe hearing loss at P21 (and at 7, 10, or 19 weeks of age), with click-evoked ABR thresholds averaging 76 decibles sound pressure level (dB SPL) compared to 11 dB SPL in controls

growth/size/body

decreased body size ( J:98303 )

digestive/alimentary system

abnormal digestive system physiology ( J:98303 )

• abnormalities in gastrointestinal tract function

nervous system

increased cochlear outer hair cell number ( J:98303 )

• extra outer hair cells found in patches alternating with regions containing the normal three rows at P0-P5

Allelic Composition	Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (15 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (15 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

reproductive system

prostate gland epithelial hyperplasia ( J:192348 )

• at 8 months of age, multiple small focal areas of ductal hyperplasia with increased epithelial cell number and stratification without dysplastic features are seen in the prostate

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• by 14 months of age, ductal hyperplasia is seen in all mutant prostates and ducts occasionally show multilayered epithelium with atypical cells and nuclear pleomorphism typical of low-grade PIN

Allelic Composition	Pten^tm2.1Ppp/Pten⁺ Spry1^tm1Jdli/Spry1^tm1.1Jdli Spry2^tm1Mrt/Spry2^tm1.1Mrt Tg(Osr1-cre)4Mrt/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm2.1Ppp mutation (0 available); any Pten mutation (81 available)
Spry1^tm1.1Jdli mutation (0 available); any Spry1 mutation (15 available)
Spry1^tm1Jdli mutation (1 available); any Spry1 mutation (15 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry2^tm1Mrt mutation (1 available); any Spry2 mutation (24 available)
Tg(Osr1-cre)4Mrt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:192348 )

• evidence of invasion, including clusters of epithelial cells in the mesenchyme and vasculature and loss of the smooth muscle around ducts, is seen associated with high-grade PIN, indicating transition to invasive cancer

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

• ductal lumens are filled with atypical and dysplastic cells that distort the overall ductal architecture and are associated with areas of necrosis and abnormal intraepithelial vessels typical of high-grade PIN

reproductive system

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:192348 )

increased prostate intraepithelial neoplasia incidence ( J:192348 )

• prostates at 6 months of age show multiple, widely spaced areas with low-grade PIN and occasional ducts with high-grade PIN

• at 12-14 months of age, about 50% of ducts show low-grade PIN and about 15% show high-grade PIN compared to 5-10% of control ducts showing PIN

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:192348

Allelic Composition	Kras^tm4Tyj/Kras⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

impaired branching involved in bronchus morphogenesis ( J:119477 )

• lungs at E12.5 show increased branching compared to Kras; Meox2-cre, Spry2-wild-type lungs; bronchi number is increased, but is still less than age-matched wild-type

Allelic Composition	Ednrb^s-36Pub/Ednrb⁺ Spry2^tm1.1Mrt/Spry2⁺
Genetic Background	involves: 101/Rl * 129P2/OlaHsd * C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-36Pub mutation (0 available); any Ednrb mutation (103 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

digestive/alimentary system

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

growth/size/body

abnormal palatal rugae morphology ( J:125229 )

• rugae morphology is disorganized and fragmented in cleft palate, whereas wild-type palates exhibit orderly array of 7-9 rugae

cleft secondary palate ( J:125229 )

• compound mutants display 35% incidence of cleft secondary palate

Allelic Composition	Spry2^tm1.1Mrt/Spry2^tm1.1Mrt Spry4^tm1.2Mrt/Spry4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)
Spry4^tm1.2Mrt mutation (1 available); any Spry4 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:315670 )

• display ciliopathy-like limb phenotypes

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

limbs/digits/tail

abnormal autopod morphology ( J:315670 )

• defects in autopodium patterning

• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly

neoplasm

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ciliopathy		DOID:0060340		J:315670

Allelic Composition	Spry2^tm1.1Mrt/Spry2⁺ Spry4^tm1.2Mrt/Spry4^tm1.2Mrt
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:315670 )

• display ciliopathy-like limb long bone phenotypes

short tibia ( J:315670 )

• at E18.5

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

abnormal chondrocyte morphology ( J:315670 )

• axoneme elongation is seen in primary cilia of prenatal tibial chondrocytes

limbs/digits/tail

abnormal autopod morphology ( J:315670 )

• defects in autopodium patterning

• display variable forms and combinations of forelimb abnormalities, including polydactyly, brachydactyly, and syndactyly

short tibia ( J:315670 )

• at E18.5

cellular

abnormal primary cilium morphology ( J:315670 )

• axoneme elongation is seen in prenatal tibial chondrocytes

neoplasm

increased enchondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

increased osteochondroma incidence ( J:315670 )

• located in ossified central areas of ribs and in the distal zone of long limb bones adjacent to disarranged growth plate

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
ciliopathy		DOID:0060340		J:315670

Allelic Composition	Fgfr1^tm1.1Jpa/Fgfr1⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1^tm1.1Jpa mutation (0 available); any Fgfr1 mutation (221 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

supernumerary teeth ( J:119280 )

• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone

growth/size/body

supernumerary teeth ( J:119280 )

• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone

skeleton

supernumerary teeth ( J:119280 )

• frequency of diastema tooth formation is reduced to 60% compared to almost 100% in mice homozygous for the Spry2 allele alone

Allelic Composition	Fgfr2^tm1.1Dor/Fgfr2⁺ Spry2^tm1.1Mrt/Spry2^tm1.1Mrt
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2^tm1.1Dor mutation (0 available); any Fgfr2 mutation (87 available)
Spry2^tm1.1Mrt mutation (1 available); any Spry2 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:119280 )

N	• unlike in mice homozygous for the Spry2 allele alone, no diastema tooth formation is seen

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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