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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rock1tm1Sna
targeted mutation 1, Shuh Narumiya
MGI:3578223
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rock1tm1Sna/Rock1tm1Sna B6N.129X1-Rock1tm1Sna MGI:3578283


Genotype
MGI:3578283
hm1
Allelic
Composition
Rock1tm1Sna/Rock1tm1Sna
Genetic
Background
B6N.129X1-Rock1tm1Sna
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rock1tm1Sna mutation (0 available); any Rock1 mutation (57 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Eyes open at birth and omphalocele phenotypes of Rock1tm1Sna/Rock1tm1Sna mice

mortality/aging
• homozygous null mice were underrepresented among littermates at 4 weeks of age and most (though some survived) died soon after birth as a result of cannibalization of the omphalocele by the mother

vision/eye
• 50% of the surviving homozygotes gradually developed proliferative inflammation of the eyelid that almost covered the entire eye at 5-6 months of age
• actin cables that encircle the eye in the epithelial cells of the eyelid were disorganized
• impaired or delayed extension of the eyelid epithelial sheet resulting in open eyelids from E16.5 to birth
• 50% had fully open eyelids while the rest were almost fully fused but manifested a hole with a diameter of less than 1 mm

immune system
• 50% of the surviving homozygotes gradually developed proliferative inflammation of the eyelid that almost covered the entire eye at 5-6 months of age

growth/size/body
• 26.5% exhibited severe omphalocele, including the liver and small intestine, 38.2% exhibited moderate omphalocele, with only the small intestine protruding, and 35.3% exhibited mild omphalocele, in which the intestine protrudes upon crying
• omphalocele resulted from an impaired umbilical ring closure due to failure of actin assembly in the epithelium at the site of epidermal ridge formation

integument
• only 11 and 20% of homozygous null keratinocytes contained actin bundles at 30 and 120 min after EGF stimulation compared to 33 and 56.4% in wildtype and these actin bundles were thinner and fewer in number





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory