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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ajubatm1Gdl
targeted mutation 1, Gregory D Longmore
MGI:3578221
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ajubatm1Gdl/Ajubatm1Gdl involves: 129X1/SvJ * C57BL/6 MGI:3578294


Genotype
MGI:3578294
hm1
Allelic
Composition
Ajubatm1Gdl/Ajubatm1Gdl
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ajubatm1Gdl mutation (2 available); any Ajuba mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• homozygous null MEFs displayed a marked inhibition of migration in a scratch-wound repair assay, covering only 20-30% of the wound area compared to complete wound closure in wildtype, however homozygous null mice were viable and reached adulthood without any obvious phenotypes
• migrating homozygous null MEFs exhibited abnormal lamellipodia production with decreased levels and activation of FAK, p130Cas, and Rac1





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory