Phenotypes associated with this allele

• Allele Symbol: Lims1^tm1.2Chen
• Allele Name: targeted mutation 1.2, Ju Chen
• Allele ID: MGI:3577473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lims1^tm1.2Chen/Lims1^tm1.2Chen	involves: 129S1/Sv * 129X1/SvJ * Black Swiss	MGI:3577519

Genotype
MGI:3577519

hm1

• Allelic Composition: Lims1^tm1.2Chen/Lims1^tm1.2Chen
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:97635 )

• no viable embryos were found at E7.5 and embryos were abnormal at E5.5, indicating that embryos die shortly after implantation

embryo

embryonic growth arrest ( J:97635 )

• E5.5-E8.5 embryos were developmentally retarded and resorption of embryos was observed at E7.5 and E8.5

decreased embryo size ( J:97635 )

• embryos were small at E5.5 and E6.5

abnormal egg cylinder morphology ( J:97635 )

• disorganized inner and outer layers at E5.5

absent proamniotic cavity ( J:97635 )

• proamniotic cavity was missing at E5.5

cellular

abnormal cell death ( J:97635 )

• excessive cell death in E5.5 embryos

decreased cell proliferation ( J:97635 )

• significant reduction in the rate of cell proliferation in E5.5 embryos

growth/size/body

decreased embryo size ( J:97635 )

• embryos were small at E5.5 and E6.5