All Phenotypes Safb<tm1So> MGI Mouse

neonatal lethality, complete penetrance ( J:97633 )

• some homozygotes die 1 - 3 days after birth without any milk in their stomachs

embryonic lethality during organogenesis, incomplete penetrance ( J:97633 )

• some homozygotes die before E10.5

increased male germ cell apoptosis ( J:97633 )

• increased apoptosis of male germ cells is associated with tubular degeneration

abnormal sex gland physiology ( J:97633 )

abnormal female reproductive system morphology ( J:97633 )

decreased primary ovarian follicle number ( J:97633 )

• females had decreased numbers of primary follicles by 4 weeks of age

decreased primordial ovarian follicle number ( J:97633 )

• females had decreased numbers of primordial follicles by 4 weeks of age

ovary atrophy ( J:97633 )

• ovarian atrophy is associated with the decrease in follicle number

small oviduct ( J:97633 )

• in females that failed to become pregnant 4 out of 6 had a thinner muscle layer around the oviduct and the oviducts were disproportionately smaller than normal

oviduct atrophy ( J:97633 )

• in females that failed to become pregnant 4 out of 6 had smaller oviducts that showed atrophy with increasing age

abnormal gametogenesis ( J:97633 )

decreased male germ cell number ( J:97633 )

• seen in homozygous males at 3 weeks of age and becomes more severe with age

azoospermia ( J:97633 )

arrest of spermatogenesis ( J:97633 )

• testosterone treatment can restore sperm development

abnormal male reproductive system morphology ( J:97633 )

abnormal branching involved in seminal vesicle morphogenesis ( J:97633 )

• the seminal vesicles have more primitive columnar epithelium without branching into secondary and tertiary folds

small seminal vesicle ( J:97633 )

seminiferous tubule degeneration ( J:97633 )

increased Leydig cell number ( J:97633 )

decreased testis weight ( J:97633 )

• paired testes weight was reduced by about 80% compared to wild-type littermates after correction for the decreased body weight

abnormal oviduct transport ( J:97633 )

• in females that failed to become pregnant at 3.5 days post conception embryos are still found in the oviducts rather than in the uterus as in wild-type females

abnormal fertility/fecundity ( J:97633 )

reduced female fertility ( J:97633 )

• copulation is normal but fertility is reduced with some females failing to produce any litters and others producing only a single litter

decreased litter size ( J:97633 )

male infertility ( J:97633 )

absent gastric milk in neonates ( J:97633 )

• homozygotes that die after birth have no milk in their stomachs

reduced male mating frequency ( J:97633 )

• only 1 out of 4 males bred when paired with superovulated C57BL/6 females

decreased body size ( J:97633 )

decreased body weight ( J:97633 )

• at 3 weeks of age, homozygous males and females weigh 45% and 30% less, respectively, than their wild-type littermates

• the weight difference remained constant during pubertal growth

decreased fetal size ( J:97633 )

• about 20% smaller than wild-type littermates starting at E15

decreased circulating testosterone level ( J:97633 )

• seen in males and pregnant females

decreased circulating estradiol level ( J:97633 )

• seen in pregnant females

decreased circulating insulin-like growth factor I level ( J:97633 )

• serum levels of insulin-like growth factor 1 are decreased

cyanosis ( J:97633 )

• newborn pups have cyanotic skin

abnormal liver morphology ( J:97633 )

• at E19 mutant livers have fewer erythrocytes and in 3 out of 5 livers a decreased number of blood vessels

small thoracic cage ( J:97633 )

• the overall size of the skeleton is significantly decreased with the most pronounced decrease seen in the thorax

abnormal lung alveolus development ( J:97633 )

• incomplete maturation of the alveoli is seen