Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cryaa-TAg,Ins2-CALM1)26Ove mutation
(1 available)
Tg(Myh6-SOD2,Tyr)3Pne mutation
(1 available)
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cellular
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N |
• no diabetes-induced increases in mitochondrial area, number, protein, or DNA content are observed
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homeostasis/metabolism
cardiovascular system
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N |
• no damage is seen in the heart in contrast to single transgenic Tg(Ins2-CALM1)26Ove mice
• contractile parameters are normalized in double transgenic hearts
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cryaa-TAg,Ins2-CALM1)26Ove mutation
(1 available)
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homeostasis/metabolism
renal/urinary system
endocrine/exocrine glands
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• the number of beta cells per islet was reduced
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• reduced pancreatic insulin levels; early onset and increased severity with age
• pancreatic insulin content was 28% of control levels
• insulin mRNA levels were also reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cryaa-TAg,Ins2-CALM1)26Ove mutation
(1 available)
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cellular
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• swollen mitochondria and broken mitochondrial double membranes are observed
• hearts have increased mitochondrial mass, as well as greater area and number
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• respiratory control ratio (RCR) and state 3 respiration are significantly impaired in mitochondria
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cardiovascular system
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• hearts have many focal areas of damage with swollen mitochondria, mottled matrix and broken mitochondrial double membranes
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• progressive increase in renal vascular resistance beginning at 3 months of age
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• diastolic blood pressure is elevated in conscious mutants at 3 months of age when measured using a tail-cuff monitor
• by 8 months of age, both diastolic and systolic blood pressure is increased in conscious mutants
• under anesthesia, when measured by intravascular connulation, mutants exhibit a similar blood pressure to anesthetized controls, however this is reduced compared to conscious mutants
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homeostasis/metabolism
adipose tissue
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• loss of fat tissue by 5 months of age
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growth/size/body
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N |
• mutants exhibit normal weight gain and body weight
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• loss of fat tissue by 5 months of age
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• 2-fold increase in kidney weight between 2 and 5 months of age
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liver/biliary system
renal/urinary system
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• progressive increase in renal vascular resistance beginning at 3 months of age
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• albumin excretion rate increases progressively with age and exceeds 15,000 ug/24 hr at 9 months of age
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• kidney shows dilation of the ducts, atrophy of tubular cells, protein casts in the duct lumen, and prominent infiltration of mononuclear cells
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• 2-fold increase in kidney weight between 2 and 5 months of age
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• glomeruli exhibit a thickened and irregular basement membrane
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• expanded mesangium showing enlarged mesangial fraction and mesangial volume, with the greatest rate increase during 2.5-6 months of age
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• diffuse and nodular expansion of mesangial matrix in mutants over 2 months of age
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• diffuse and nodular glomerulosclerotic lesions
• nodules are acellular and are similar to Kimmelsteil-Wilson lesions in size
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• glomerular volume is enlarged, with the greatest rate increase during 2.5-6 months of age
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• seen in many mutants over 5 months of age
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• expansion of kidney tubules; average cortical tubule cross-sectional area (minus the lumen) is 34% greater in 9 month old mutants than controls
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• significant fibrosis in the kidney by 5 months of age
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• tubulointerstitial fibrosis
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• many mutants over 5 months of age exhibit bladder stasis
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• distended bladders are seen in many mutants over 5 months of age
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• glomerular filtration rate increases significantly from 2 to 3 months of age but then decreases significantly from 5 to 9 months of age
• decline in glomerular filtration rate coincides with an increase in renal vascular resistance
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Analysis Tools