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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gata6tm1Sad
targeted mutation 1, Stephen A Duncan
MGI:3576383
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gata6tm1Sad/Gata6tm1Sad involves: 129S1/Sv * 129X1/SvJ MGI:3576513


Genotype
MGI:3576513
hm1
Allelic
Composition
Gata6tm1Sad/Gata6tm1Sad
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6tm1Sad mutation (0 available); any Gata6 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• tetraploid rescued ES cell derived homozygous embryos die around E10.5

liver/biliary system
• in tetraploid rescued ES cell derived homozygous embryos, the liver bud forms but fails to expand by E10.5 and at E10.5 the liver bud is virtually indiscernible indicating a failure of the hepatoblasts to delaminate from the foregut
• however as in controls, the septum transversum mesenchyme surrounds the hepatic bud

embryo
• tetraploid rescued ES cell derived homozygous embryos are smaller than control embryos but develop at the same rate

cardiovascular system
N
• in tetraploid rescued ES cell derived homozygous embryos, at E9.5, cardiogenesis and endothelial cell development are normal

growth/size/body
• tetraploid rescued ES cell derived homozygous embryos are smaller than control embryos but develop at the same rate





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory