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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Izumo1tm1Osb
targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:3576382
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Izumo1tm1Osb/Izumo1tm1Osb involves: 129S2/SvPas * C57BL/6 MGI:3576518


Genotype
MGI:3576518
hm1
Allelic
Composition		 Izumo1tm1Osb/Izumo1tm1Osb
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Izumo1tm1Osb mutation (2 available); any Izumo1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
male infertility ( J:97563 )
• males are sterile despite normal mating behavior and ejaculation
impaired fertilization ( J:97563 )
• mutant sperm fail to fuse with eggs; however, mutant sperm are capable of penetrating the zona pellucida, undergoing the acrosome reaction and binding to the plasma membrane of zona-free eggs and exhibit no reduction in sperm motility




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory