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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ins2*Y16A)1Ell
transgene insertion 1, John F Elliot
MGI:3576358
Summary 3 genotypes


Genotype
MGI:3619380
cx1
Allelic
Composition		 Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0
Genetic
Background		 NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (5 available); any Ins1 mutation (44 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (93 available)
Tg(Ins2*Y16A)1Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:98583 )
• male transgenic mice lacking both native insulin genes develop diabetes before 10 weeks of age (2 consecutive measurements of >250 mg/dl glucose)

immune system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis
decreased susceptibility to autoimmune diabetes ( J:98583 )
• female transgenic mice lacking both native insulin genes do not exhibit diabetes by 30 weeks of age

endocrine/exocrine glands
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

digestive/alimentary system
salivary gland inflammation ( J:98583 )
• at 26 weeks of age, sialitis is observed but not insulitis

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583




Genotype
MGI:3619388
cx2
Allelic
Composition		 Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0
Genetic
Background		 NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (5 available); any Ins1 mutation (44 available)
Tg(Ins2*Y16A)1Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:98583 )
• 75% of female transgenic mice lacking Ins2 develop diabetes (2 consecutive blood glucose measurements of >250 mg/dl) by 25 weeks of age

homeostasis/metabolism
increased circulating glucose level ( J:98583 )
• >250 mg/dl blood glucose is considered diabetic

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583




Genotype
MGI:3619408
tg3
Allelic
Composition		 Tg(Ins2*Y16A)1Ell/0
Genetic
Background		 NOD-Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2*Y16A)1Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:98583 )
• 75% of female mice carrying the transgene become diabetic in the presence of native insulin genes by 35 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory