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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ins2*Y16A)1Ell
transgene insertion 1, John F Elliot
MGI:3576358
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0
NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell MGI:3619380
cx2
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0
NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell MGI:3619388
tg3
Tg(Ins2*Y16A)1Ell/0 NOD-Tg(Ins2*Y16A)1Ell MGI:3619408


Genotype
MGI:3619380
cx1
Allelic
Composition
Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0
Genetic
Background
NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (4 available); any Ins1 mutation (31 available)
Ins2tm1Jja mutation (4 available); any Ins2 mutation (25 available)
Tg(Ins2*Y16A)1Ell mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• male transgenic mice lacking both native insulin genes develop diabetes before 10 weeks of age (2 consecutive measurements of >250 mg/dl glucose) (J:98583)
• male transgenic mice lacking both native insulin genes develop diabetes before 10 weeks of age (2 consecutive measurements of >250 mg/dl glucose) (J:98583)

immune system
• at 26 weeks of age, sialitis is observed but not insulitis (J:98583)
• at 26 weeks of age, sialitis is observed but not insulitis (J:98583)
• female transgenic mice lacking both native insulin genes do not exhibit diabetes by 30 weeks of age (J:98583)
• female transgenic mice lacking both native insulin genes do not exhibit diabetes by 30 weeks of age (J:98583)

endocrine/exocrine glands
• at 26 weeks of age, sialitis is observed but not insulitis (J:98583)
• at 26 weeks of age, sialitis is observed but not insulitis (J:98583)

digestive/alimentary system
• at 26 weeks of age, sialitis is observed but not insulitis (J:98583)
• at 26 weeks of age, sialitis is observed but not insulitis (J:98583)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583




Genotype
MGI:3619388
cx2
Allelic
Composition
Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0
Genetic
Background
NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (4 available); any Ins1 mutation (31 available)
Tg(Ins2*Y16A)1Ell mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 75% of female transgenic mice lacking Ins2 develop diabetes (2 consecutive blood glucose measurements of >250 mg/dl) by 25 weeks of age (J:98583)
• 75% of female transgenic mice lacking Ins2 develop diabetes (2 consecutive blood glucose measurements of >250 mg/dl) by 25 weeks of age (J:98583)

homeostasis/metabolism
• >250 mg/dl blood glucose is considered diabetic (J:98583)
• >250 mg/dl blood glucose is considered diabetic (J:98583)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583




Genotype
MGI:3619408
tg3
Allelic
Composition
Tg(Ins2*Y16A)1Ell/0
Genetic
Background
NOD-Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2*Y16A)1Ell mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 75% of female mice carrying the transgene become diabetic in the presence of native insulin genes by 35 weeks of age (J:98583)
• 75% of female mice carrying the transgene become diabetic in the presence of native insulin genes by 35 weeks of age (J:98583)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory