Mouse Genome Informatics
cx1
    Ins1tm1Jja/Ins1tm1Jja
Ins2tm1Jja/Ins2tm1Jja
Tg(Ins2*Y16A)1Ell/0

NOD.Cg-Ins1tm1Jja Ins2tm1Jja Tg(Ins2*Y16A)1Ell
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• male transgenic mice lacking both native insulin genes develop diabetes before 10 weeks of age (2 consecutive measurements of >250 mg/dl glucose)

immune system
• at 26 weeks of age, sialitis is observed but not insulitis
• female transgenic mice lacking both native insulin genes do not exhibit diabetes by 30 weeks of age

endocrine/exocrine glands
• at 26 weeks of age, sialitis is observed but not insulitis

digestive/alimentary system
• at 26 weeks of age, sialitis is observed but not insulitis

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583


Mouse Genome Informatics
cx2
    Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0

NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• 75% of female transgenic mice lacking Ins2 develop diabetes (2 consecutive blood glucose measurements of >250 mg/dl) by 25 weeks of age

homeostasis/metabolism
• >250 mg/dl blood glucose is considered diabetic

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:98583


Mouse Genome Informatics
tg3
    Tg(Ins2*Y16A)1Ell/0
NOD-Tg(Ins2*Y16A)1Ell
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• 75% of female mice carrying the transgene become diabetic in the presence of native insulin genes by 35 weeks of age