Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
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immune system
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• the number of transitional-2 B lymphocytes in the lymph nodes is decreased
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• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased
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• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced
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• CD1d-restricted NKT cells are absent
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• IgG viral and T-dependent antigen-specific antibody responses are impaired; however, no defect in T-independent responses is seen
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• in specific pathogen-free conditions basal serum levels of IgG1 are decreased
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• in specific pathogen-free conditions serum IgG2a levels are increased
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• after viral infection reduced primary antigen-specific IgM responses are seen
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen
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hematopoietic system
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• the number of transitional-2 B lymphocytes in the lymph nodes is decreased
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• the number of CD21-Igm-B220+ and CD21-CD23-B220+ B cells is increased
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• the frequency of NKT cells in the lymph node, spleen, liver and thymus is reduced
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• CD1d-restricted NKT cells are absent
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• in specific pathogen-free conditions basal serum levels of IgG1 are decreased
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• in specific pathogen-free conditions serum IgG2a levels are increased
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• after viral infection reduced primary antigen-specific IgM responses are seen
• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
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immune system
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• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles
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• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant
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• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen
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hematopoietic system
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• after immunization with TNP-KLH/alum fewer than 2% of splenic follicles contain germinal centers compared to greater than 50% of wild-type follicles
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• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgG isotypes were seen, including both primary and secondary IgG responses
• IgG, IgG1, and IgG2a serum titers were also reduced following immunization with OVA and Freund's adjuvant
|
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• after immunization with TNP-KLH/alum reduced serum titers of all antigen specific IgM isotypes were seen
|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
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immune system
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• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice
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hematopoietic system
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• in vivo clearance of RMAS/CD48+ tumors cells is impaired compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
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immune system
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N |
• NK T cells are functionally competent in mice on a background with BALB/c unlike in mice on a background with C57BL/6
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• reduced in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6
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• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
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• following immunization with NP-KLH
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• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced
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• NP-specific IgG following immunization with NP-KLH
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• when activated in vitro by anti-CD3 and anti-CD28 stimulation T cells express very low amounts of IL4, IL10, and IL13; however under polarizing Th2 conditions T cells produce normal amounts of IL4, IL10, and IL13
• after infection with Leishmania major draining lymph node cells produce less IL4, IL10, and IL13
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• footpad lesions and parasite burdens are reduced in homozygotes following Leishmania major infection
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hematopoietic system
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• reduced in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6
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• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
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• following immunization with NP-KLH
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• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced
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• NP-specific IgG following immunization with NP-KLH
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
|
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cellular
|
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• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
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immune system
|
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• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
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• nearly absent in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with C57BL/6 is greater than in mice on a background with BALB/c
|
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• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
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• Background Sensitivity: NK T cells from mice on a background with C57BL/6 fail to exhibit a response to NP-KLH with alpha-GalCer unlike cells from mice on a background with BALB/c
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• mice fail to exhibit a late primary antibody response on transfer of OT-II CD4+ T cells compared with controls
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• Background Sensitivity: following exposure to NP-KLH with alpha-GalCer, mice on a background with C57BL/6 fail to exhibit an increase in anti-NP IgG unlike mice on a background with BALB/c
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• IFNG secretion by splenic and hepatic CD8+ T cells is increased after viral infection compared to wild-type mice
• with anti-CD3 stimulation under neutral conditions mutant T cell produce 12-fold more INFG
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• 14 days after infection with a hepatotropic strain of lymphocytic choriomeningitis virus homozygotes had all died, whereas only 30% of wild-type littermates had died
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hematopoietic system
|
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• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
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• nearly absent in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with C57BL/6 is greater than in mice on a background with BALB/c
|
|
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• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
|
|
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• Background Sensitivity: following exposure to NP-KLH with alpha-GalCer, mice on a background with C57BL/6 fail to exhibit an increase in anti-NP IgG unlike mice on a background with BALB/c
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• Background Sensitivity: NK T cells from mice on a background with C57BL/6 fail to exhibit a response to NP-KLH with alpha-GalCer unlike cells from mice on a background with BALB/c
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Allelic
Composition |
Sh2d1atm1Cpt/Sh2d1a+
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Genetic
Background |
involves: 129S4/SvJae * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
|
|
immune system
|
|
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
|
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• IFNG secretion by splenic and hepatic CD8+ T cells is increased after viral infection compared to wild-type mice
|
hematopoietic system
|
|
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
cellular
|
|
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
Tcra-Jtm1Tgi mutation
(0 available);
any
Tcra-J mutation
(0 available)
|
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immune system
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• following immunization with NP-KLH
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• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background
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hematopoietic system
|
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• following immunization with NP-KLH
|
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• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
Tcra-Jtm1Tgi mutation
(0 available);
any
Tcra-J mutation
(0 available)
|
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hematopoietic system
 |
• following immunization with NP-KLH
|
|
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• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background
|
immune system
|
|
• following immunization with NP-KLH
|
|
|
• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
Sh2d1b1/Sh2d1b2tm1.1Cpt mutation
(0 available);
any
Sh2d1b1 mutation
(8 available)
|
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immune system
|
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• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice
|
hematopoietic system
|
|
• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
Sh2d1b1/Sh2d1b2tm1.1Cpt mutation
(0 available);
any
Sh2d1b2 mutation
(6 available)
|
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immune system
|
|
• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice
|
hematopoietic system
|
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• in vivo clearance of RMAS/CD48+ or P815/CD48+ tumors cells is impaired compared to in wild-type mice
|
Allelic
Composition |
Sh2d1atm1Cpt/Y
|
|
Genetic
Background |
involves: 129S4/SvJae * BALB/c |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
|
|
hematopoietic system
|
|
• reduced in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6
|
|
|
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
|
|
|
• following immunization with NP-KLH
|
|
|
• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced
|
|
|
• NP-specific IgG following immunization with NP-KLH
|
immune system
|
N |
• NK T cells are functionally competent in mice on a background with BALB/c unlike in mice on a background with C57BL/6
|
|
|
• reduced in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with BALB/c is not as severe as in mice on a background with C57BL/6
|
|
|
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
|
|
|
• following immunization with NP-KLH
|
|
|
• basal IgE levels and production after infection with Leishmania major or immunization with ovalbumin are reduced
|
|
|
• NP-specific IgG following immunization with NP-KLH
|
|
|
• when activated in vitro by anti-CD3 and anti-CD28 stimulation T cells express very low amounts of IL4, IL10, and IL13; however under polarizing Th2 conditions T cells produce normal amounts of IL4, IL10, and IL13
• after infection with Leishmania major draining lymph node cells produce less IL4, IL10, and IL13
|
|
|
• footpad lesions and parasite burdens are reduced in homozygotes following Leishmania major infection
|
Allelic
Composition |
Sh2d1atm1Cpt/Y
|
|
Genetic
Background |
involves: 129S4/SvJae * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1atm1Cpt mutation
(0 available);
any
Sh2d1a mutation
(10 available)
|
|
|
cellular
|
|
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
hematopoietic system
|
|
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
|
|
• nearly absent in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with C57BL/6 is greater than in mice on a background with BALB/c
|
|
|
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
|
|
|
• Background Sensitivity: following exposure to NP-KLH with alpha-GalCer, mice on a background with C57BL/6 fail to exhibit an increase in anti-NP IgG unlike mice on a background with BALB/c
|
|
|
• Background Sensitivity: NK T cells from mice on a background with C57BL/6 fail to exhibit a response to NP-KLH with alpha-GalCer unlike cells from mice on a background with BALB/c
|
immune system
|
|
• increased numbers of CD8+ and CD4+ T cells are found in the spleen and liver after viral infection compared to wild-type mice
|
|
|
• nearly absent in the thymus, spleen and liver
• Background Sensitivity: reduction in NK T cells in mice on a background with C57BL/6 is greater than in mice on a background with BALB/c
|
|
|
• following exposure to NP-KLH with alpha-GalCer, germinal center B cells fail to exhibit an increase in numbers unlike in control mice
|
|
|
• Background Sensitivity: NK T cells from mice on a background with C57BL/6 fail to exhibit a response to NP-KLH with alpha-GalCer unlike cells from mice on a background with BALB/c
|
|
|
• mice fail to exhibit a late primary antibody response on transfer of OT-II CD4+ T cells compared with controls
|
|
|
• Background Sensitivity: following exposure to NP-KLH with alpha-GalCer, mice on a background with C57BL/6 fail to exhibit an increase in anti-NP IgG unlike mice on a background with BALB/c
|
|
|
• IFNG secretion by splenic and hepatic CD8+ T cells is increased after viral infection compared to wild-type mice
• with anti-CD3 stimulation under neutral conditions mutant T cell produce 12-fold more INFG
|
|
|
• 14 days after infection with a hepatotropic strain of lymphocytic choriomeningitis virus homozygotes had all died, whereas only 30% of wild-type littermates had died
|
Analysis Tools