About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptgs1tm1Fun
targeted mutation 1, Colin D Funk
MGI:3576237
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptgs1tm1Fun/Ptgs1tm1Fun involves: 129S6/SvEvTac * C57BL/6 MGI:3576657
cx2
Ptgs1tm1Fun/Ptgs1tm1Fun
Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB MGI:3701213


Genotype
MGI:3576657
hm1
Allelic
Composition
Ptgs1tm1Fun/Ptgs1tm1Fun
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1tm1Fun mutation (1 available); any Ptgs1 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to arachidonic acid and capsaicin in an ear swelling assay or carrageenan treatment in a paw edema assay
• no inflammatory protection was observed with tetradecanoyl phorbol acetate (TPA) and croton oil induced inflammation

hematopoietic system
• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets
• mice were resistant to arachidonic acid induced thrombosis in vivo

reproductive system
N
• normal gestational length, normal parturition, normal litter size and development, normal ovaries size and weight

homeostasis/metabolism
• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets
• mice were resistant to arachidonic acid induced thrombosis in vivo
• tail bleeding time was significantly prolonged
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2
• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

renal/urinary system
• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

Mouse Models of Human Disease
OMIM ID Ref(s)
Preeclampsia/Eclampsia 1; PEE1 189800 J:97351




Genotype
MGI:3701213
cx2
Allelic
Composition
Ptgs1tm1Fun/Ptgs1tm1Fun
Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1tm1Fun mutation (1 available); any Ptgs1 mutation (12 available)
Ptgs2tm2.1(Ptgs1)Fun mutation (1 available); any Ptgs2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no homozygous offspring are produced from double heterozygous matings





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory