Mouse Genome Informatics
hm1
    Ptgs1tm1Fun/Ptgs1tm1Fun
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• in response to arachidonic acid and capsaicin in an ear swelling assay or carrageenan treatment in a paw edema assay
• no inflammatory protection was observed with tetradecanoyl phorbol acetate (TPA) and croton oil induced inflammation

hematopoietic system
• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets
• mice were resistant to arachidonic acid induced thrombosis in vivo

reproductive system
N
• normal gestational length, normal parturition, normal litter size and development, normal ovaries size and weight (J:97351)

homeostasis/metabolism
• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets
• mice were resistant to arachidonic acid induced thrombosis in vivo
• tail bleeding time was significantly prolonged
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2
• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

renal/urinary system
• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

Mouse Models of Human Disease
OMIM IDRef(s)
Preeclampsia/Eclampsia 1; PEE1 189800 J:97351


Mouse Genome Informatics
cx2
    Ptgs1tm1Fun/Ptgs1tm1Fun
Ptgs2tm2.1(Ptgs1)Fun/Ptgs2tm2.1(Ptgs1)Fun

involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no homozygous offspring are produced from double heterozygous matings