Phenotypes associated with this allele

• Allele Symbol: Ptgs1^tm1Fun
• Allele Name: targeted mutation 1, Colin D Funk
• Allele ID: MGI:3576237
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptgs1^tm1Fun/Ptgs1^tm1Fun	involves: 129S6/SvEvTac * C57BL/6	MGI:3576657
cx2	Ptgs1^tm1Fun/Ptgs1^tm1Fun Ptgs2^tm2.1(Ptgs1)Fun/Ptgs2^tm2.1(Ptgs1)Fun	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB	MGI:3701213

Genotype
MGI:3576657

hm1

• Allelic Composition: Ptgs1^tm1Fun/Ptgs1^tm1Fun
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased inflammatory response ( J:97351 )

• in response to arachidonic acid and capsaicin in an ear swelling assay or carrageenan treatment in a paw edema assay

• no inflammatory protection was observed with tetradecanoyl phorbol acetate (TPA) and croton oil induced inflammation

hematopoietic system

decreased platelet aggregation ( J:97351 )

• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets

reproductive system

reproductive system phenotype ( J:97351 )

N • normal gestational length, normal parturition, normal litter size and development, normal ovaries size and weight

homeostasis/metabolism

decreased platelet aggregation ( J:97351 )

• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets

decreased susceptibility to induced thrombosis ( J:97351 )

• mice were resistant to arachidonic acid induced thrombosis in vivo

increased bleeding time ( J:97351 )

• tail bleeding time was significantly prolonged

abnormal thromboxane level ( J:108957 )

• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

decreased urine prostaglandin level ( J:108957 )

• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid

• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

renal/urinary system

decreased urine prostaglandin level ( J:108957 )

• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid

• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pre-eclampsia		DOID:10591	OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592	J:97351

Genotype
MGI:3701213

cx2

• Allelic Composition: Ptgs1^tm1Fun/Ptgs1^tm1Fun; Ptgs2^{tm2.1(Ptgs1)Fun}/Ptgs2^{tm2.1(Ptgs1)Fun}
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB

mortality/aging

prenatal lethality ( J:118171 )

• no homozygous offspring are produced from double heterozygous matings