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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Park7tm1Dsp
targeted mutation 1, David S Park
MGI:3576227
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Park7tm1Dsp/Park7tm1Dsp B6.129P2-Park7tm1Dsp MGI:3576369


Genotype
MGI:3576369
hm1
Allelic
Composition
Park7tm1Dsp/Park7tm1Dsp
Genetic
Background
B6.129P2-Park7tm1Dsp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Park7tm1Dsp mutation (1 available); any Park7 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show increased striatal denervation and dopaminergic neuron loss induced by 1-methyl-4pheny-1,2,3,6-terahydropyrindine
• mutant embryonic cortical neurons show increased sensitivity to oxidative insults

behavior/neurological
• mice show hypo-locomotion when subjected to amphetamine challenge
• 14-16 month old mice exhibit a mild motor defect on the pole test
• however, affected mice at 2, 6, and 12 months of age do not exhibit a decrease in gross motor function or in drug-induced rotational behavior
• 14-16 month old mice exhibit a mild motor defect on the grid test

nervous system
• affected mice show a reduction of dopaminergic neurons in the substantia nigra pars compacta
• the remaining fibers in the substantia nigra pars compacta exhibit an elevated number of shortened processes with neuritic beading
• 15 month old mice exhibit a decreased number of sprouting processes in the substantia nigra pars compacta region
• aged mice exhibit a reduction in Th-positive cells in the locus ceruleus
• 15 month old mice show a decrease in dopaminergic-synthesizing TH-positive striatal terminals
• mice exhibit unilateral dopamine cell loss in the substantia nigra pars compacta that progresses to bilateral loss of the nigrostriatal axis with age
• a subset of mice show unilateral substantia nigra pars compacta degeneration as early as 2 months of age, with a 42.9% penetrance peaking at 12 months of age
• 15 month old mice show bilateral nerve cell loss in the substantia nigra pars compacta
• aged mice exhibit a reduction in Th-positive cells in the locus ceruleus
• however, the ventral tegmental area is mostly spared

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 7, Autosomal Recessive Early-Onset; PARK7 606324 J:190315





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory