Mouse Genome Informatics
hm1
    Park7tm1Dsp/Park7tm1Dsp
B6.129P2-Park7tm1Dsp
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice show increased striatal denervation and dopaminergic neuron loss induced by 1-methyl-4pheny-1,2,3,6-terahydropyrindine
• mutant embryonic cortical neurons show increased sensitivity to oxidative insults

behavior/neurological
• mice show hypo-locomotion when subjected to amphetamine challenge
• 14-16 month old mice exhibit a mild motor defect on the pole test
• however, affected mice at 2, 6, and 12 months of age do not exhibit a decrease in gross motor function or in drug-induced rotational behavior
• 14-16 month old mice exhibit a mild motor defect on the grid test

nervous system
• affected mice show a reduction of dopaminergic neurons in the substantia nigra pars compacta
• the remaining fibers in the substantia nigra pars compacta exhibit an elevated number of shortened processes with neuritic beading
• 15 month old mice exhibit a decreased number of sprouting processes in the substantia nigra pars compacta region
• aged mice exhibit a reduction in Th-positive cells in the locus ceruleus
• 15 month old mice show a decrease in dopaminergic-synthesizing TH-positive striatal terminals
• mice exhibit unilateral dopamine cell loss in the substantia nigra pars compacta that progresses to bilateral loss of the nigrostriatal axis with age
• a subset of mice show unilateral substantia nigra pars compacta degeneration as early as 2 months of age, with a 42.9% penetrance peaking at 12 months of age
• 15 month old mice show bilateral nerve cell loss in the substantia nigra pars compacta
• aged mice exhibit a reduction in Th-positive cells in the locus ceruleus
• however, the ventral tegmental area is mostly spared