About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apoeshl
spontaneous hyperlipidemia
MGI:3574899
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apoeshl/Apoeshl B6.KOR-Apoeshl MGI:3716842
hm2
Apoeshl/Apoeshl C.KOR-Apoeshl MGI:3716841
hm3
Apoeshl/Apoeshl C3.KOR-Apoeshl MGI:3716840
hm4
Apoeshl/Apoeshl involves: BALB/c * KOR MGI:3716845
hm5
Apoeshl/Apoeshl involves: C3H/He * KOR MGI:3716844
hm6
Apoeshl/Apoeshl involves: C57BL/6 * KOR MGI:3716846
hm7
Apoeshl/Apoeshl KOR-Apoeshl MGI:3716839
ht8
Apoeshl/Apoetm1Unc involves: 129P2/OlaHsd * KOR MGI:3716843


Genotype
MGI:3716842
hm1
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
B6.KOR-Apoeshl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: cholesterol levels increase with age on a C57BL/6 background
• Background Sensitivity: lesions are moderate on a C57BL/6 background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl




Genotype
MGI:3716841
hm2
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
C.KOR-Apoeshl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: cholesterol levels increase with age on a BALB/c background
• Background Sensitivity: lesions are hardly apparent on a BALB/c background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl




Genotype
MGI:3716840
hm3
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
C3.KOR-Apoeshl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels decrease slightly with age on a C3H background
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: lesions are hardly apparent on a C3H background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl




Genotype
MGI:3716845
hm4
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
involves: BALB/c * KOR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Xanthoma of Apoeshl/Apoeshl mice

mortality/aging
• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism
• cholesterol levels are high prior to weaning and decrease
• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back
• at 3 months, lesions are apparent at periocular and chest regions
• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system
• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument
• associated with xanthoma lesions on chest

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:54051




Genotype
MGI:3716844
hm5
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
involves: C3H/He * KOR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Xanthoma of Apoeshl/Apoeshl mice

mortality/aging
• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism
• cholesterol levels are high prior to weaning and decrease
• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back
• at 3 months, lesions are apparent at periocular and chest regions
• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system
• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument
• associated with xanthoma lesions on chest

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:54051




Genotype
MGI:3716846
hm6
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
involves: C57BL/6 * KOR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Xanthoma of Apoeshl/Apoeshl mice

mortality/aging
• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism
• cholesterol levels are high prior to weaning and decrease
• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back
• at 3 months, lesions are apparent at periocular and chest regions
• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system
• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument
• associated with xanthoma lesions on chest

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:54051




Genotype
MGI:3716839
hm7
Allelic
Composition
Apoeshl/Apoeshl
Genetic
Background
KOR-Apoeshl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: newborns have extremely high cholesterol levels that decrease exponentially towards weaning on a KOR background
• Background Sensitivity: lesions are severe on a KOR background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl

behavior/neurological




Genotype
MGI:3716843
ht8
Allelic
Composition
Apoeshl/Apoetm1Unc
Genetic
Background
involves: 129P2/OlaHsd * KOR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoeshl mutation (1 available); any Apoe mutation (71 available)
Apoetm1Unc mutation (22 available); any Apoe mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in all mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory