Mouse Genome Informatics
hm1
    Apoeshl/Apoeshl
B6.KOR-Apoeshl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: cholesterol levels increase with age on a C57BL/6 background
• Background Sensitivity: lesions are moderate on a C57BL/6 background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl


Mouse Genome Informatics
hm2
    Apoeshl/Apoeshl
C.KOR-Apoeshl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: cholesterol levels increase with age on a BALB/c background
• Background Sensitivity: lesions are hardly apparent on a BALB/c background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl


Mouse Genome Informatics
hm3
    Apoeshl/Apoeshl
C3.KOR-Apoeshl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: cholesterol levels decrease slightly with age on a C3H background
• Background Sensitivity: lesions are hardly apparent on a C3H background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl


Mouse Genome Informatics
hm4
    Apoeshl/Apoeshl
involves: BALB/c * KOR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Xanthoma of Apoeshl/Apoeshl mice

mortality/aging
• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism
• cholesterol levels are high prior to weaning and decrease
• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back
• at 3 months, lesions are apparent at periocular and chest regions
• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system
• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument
• associated with xanthoma lesions on chest

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:54051


Mouse Genome Informatics
hm5
    Apoeshl/Apoeshl
involves: C3H/He * KOR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Xanthoma of Apoeshl/Apoeshl mice

mortality/aging
• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism
• cholesterol levels are high prior to weaning and decrease
• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back
• at 3 months, lesions are apparent at periocular and chest regions
• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system
• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument
• associated with xanthoma lesions on chest

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:54051


Mouse Genome Informatics
hm6
    Apoeshl/Apoeshl
involves: C57BL/6 * KOR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Xanthoma of Apoeshl/Apoeshl mice

mortality/aging
• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism
• cholesterol levels are high prior to weaning and decrease
• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back
• at 3 months, lesions are apparent at periocular and chest regions
• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system
• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument
• associated with xanthoma lesions on chest

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:54051


Mouse Genome Informatics
hm7
    Apoeshl/Apoeshl
KOR-Apoeshl
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoeshl, C3.KOR-Apoeshl, C.KOR-Apoeshl, and B6.KOR-Apoeshl
• Background Sensitivity: newborns have extremely high cholesterol levels that decrease exponentially towards weaning on a KOR background
• Background Sensitivity: lesions are severe on a KOR background

cardiovascular system
• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoeshl, C.KOR-Apoeshl, C3.KOR-Apoeshl, KOR-Apoeshl

behavior/neurological
(J:75488)


Mouse Genome Informatics
ht8
    Apoeshl/Apoetm1Unc
involves: 129P2/OlaHsd * KOR
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• in all mice