Phenotypes associated with this allele

• Allele Symbol: Apoe^shl
• Allele Name: spontaneous hyperlipidemia
• Allele ID: MGI:3574899
• Summary: 8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoe^shl/Apoe^shl	B6.KOR-Apoe^shl	MGI:3716842
hm2	Apoe^shl/Apoe^shl	C.KOR-Apoe^shl	MGI:3716841
hm3	Apoe^shl/Apoe^shl	C3.KOR-Apoe^shl	MGI:3716840
hm4	Apoe^shl/Apoe^shl	involves: BALB/c * KOR	MGI:3716845
hm5	Apoe^shl/Apoe^shl	involves: C3H/He * KOR	MGI:3716844
hm6	Apoe^shl/Apoe^shl	involves: C57BL/6 * KOR	MGI:3716846
hm7	Apoe^shl/Apoe^shl	KOR-Apoe^shl	MGI:3716839
ht8	Apoe^shl/Apoe^tm1Unc	involves: 129P2/OlaHsd * KOR	MGI:3716843

Genotype
MGI:3716842

hm1

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: B6.KOR-Apoe^shl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:75488 )

• Background Sensitivity: cholesterol levels increase with age on a C57BL/6 background

• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoe^shl, C3.KOR-Apoe^shl, C.KOR-Apoe^shl, and B6.KOR-Apoe^shl

xanthoma ( J:75488 )

• Background Sensitivity: lesions are moderate on a C57BL/6 background

cardiovascular system

increased susceptibility to atherosclerosis ( J:75488 )

• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoe^shl, C.KOR-Apoe^shl, C3.KOR-Apoe^shl, KOR-Apoe^shl

Genotype
MGI:3716841

hm2

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: C.KOR-Apoe^shl

homeostasis/metabolism

increased circulating cholesterol level ( J:75488 )

• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoe^shl, C3.KOR-Apoe^shl, C.KOR-Apoe^shl, and B6.KOR-Apoe^shl

• Background Sensitivity: cholesterol levels increase with age on a BALB/c background

xanthoma ( J:75488 )

• Background Sensitivity: lesions are hardly apparent on a BALB/c background

cardiovascular system

increased susceptibility to atherosclerosis ( J:75488 )

• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoe^shl, C.KOR-Apoe^shl, C3.KOR-Apoe^shl, KOR-Apoe^shl

Genotype
MGI:3716840

hm3

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: C3.KOR-Apoe^shl

homeostasis/metabolism

increased circulating cholesterol level ( J:75488 )

• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoe^shl, C3.KOR-Apoe^shl, C.KOR-Apoe^shl, and B6.KOR-Apoe^shl

• Background Sensitivity: cholesterol levels decrease slightly with age on a C3H background

xanthoma ( J:75488 )

• Background Sensitivity: lesions are hardly apparent on a C3H background

cardiovascular system

increased susceptibility to atherosclerosis ( J:75488 )

• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoe^shl, C.KOR-Apoe^shl, C3.KOR-Apoe^shl, KOR-Apoe^shl

Genotype
MGI:3716845

hm4

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: involves: BALB/c * KOR

Xanthoma of Apoe^shl/Apoe^shl mice

mortality/aging

premature death ( J:54051 )

• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism

increased circulating cholesterol level ( J:54051 )

• cholesterol levels are high prior to weaning and decrease

xanthoma ( J:54051 )

• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back

• at 3 months, lesions are apparent at periocular and chest regions

• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system

atherosclerotic lesions ( J:54051 )

• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument

alopecia ( J:54051 )

• associated with xanthoma lesions on chest

Genotype
MGI:3716844

hm5

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: involves: C3H/He * KOR

Xanthoma of Apoe^shl/Apoe^shl mice

mortality/aging

premature death ( J:54051 )

• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism

increased circulating cholesterol level ( J:54051 )

• cholesterol levels are high prior to weaning and decrease

xanthoma ( J:54051 )

• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back

• at 3 months, lesions are apparent at periocular and chest regions

• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system

atherosclerotic lesions ( J:54051 )

• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument

alopecia ( J:54051 )

• associated with xanthoma lesions on chest

Genotype
MGI:3716846

hm6

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: involves: C57BL/6 * KOR

Xanthoma of Apoe^shl/Apoe^shl mice

mortality/aging

premature death ( J:54051 )

• mice die at 14 months with females dying slightly earlier than males

homeostasis/metabolism

increased circulating cholesterol level ( J:54051 )

• cholesterol levels are high prior to weaning and decrease

xanthoma ( J:54051 )

• detected as early as 4 weeks in palms and distal forelimb extremities at 3 months, lesions are apparent at periocular and chest regions at 6 months, lesions are present in a wide range of skin areas other than head and back

• at 3 months, lesions are apparent at periocular and chest regions

• at 6 months, lesions are present in a wide range of skin areas other than head and back

cardiovascular system

atherosclerotic lesions ( J:54051 )

• atherosclerotic lesions with cholesterol-clefts and deposits in the aortic wall

integument

alopecia ( J:54051 )

• associated with xanthoma lesions on chest

Genotype
MGI:3716839

hm7

• Allelic Composition: Apoe^shl/Apoe^shl
• Genetic Background: KOR-Apoe^shl

homeostasis/metabolism

increased circulating cholesterol level ( J:75488 )

• Background Sensitivity: cholesterol levels in various genetic backgrounds are as follows (highest to lowest levels): KOR-Apoe^shl, C3.KOR-Apoe^shl, C.KOR-Apoe^shl, and B6.KOR-Apoe^shl

• Background Sensitivity: newborns have extremely high cholesterol levels that decrease exponentially towards weaning on a KOR background

xanthoma ( J:75488 )

• Background Sensitivity: lesions are severe on a KOR background

cardiovascular system

increased susceptibility to atherosclerosis ( J:75488 )

• Background Sensitivity: increased susceptibility varies based on background strain as follows (most prominent to least prominent): B6.KOR-Apoe^shl, C.KOR-Apoe^shl, C3.KOR-Apoe^shl, KOR-Apoe^shl

behavior/neurological

abnormal nursing ( J:75488 )

♀

Genotype
MGI:3716843

ht8

• Allelic Composition: Apoe^shl/Apoe^tm1Unc
• Genetic Background: involves: 129P2/OlaHsd * KOR

homeostasis/metabolism

increased circulating cholesterol level ( J:54051 )

• in all mice

xanthoma ( J:54051 )

• in all mice