All Phenotypes Akt3<tm1Mbb> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt3^tm1Mbb
targeted mutation 1, Morris J Birnbaum
MGI:3574346

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt3^tm1Mbb/Akt3^tm1Mbb	B6.Cg-Akt3^tm1Mbb	MGI:6316993
hm2	Akt3^tm1Mbb/Akt3^tm1Mbb	involves: C57BL/6J	MGI:4941198
hm3	Akt3^tm1Mbb/Akt3^tm1Mbb	Not Specified	MGI:3574757
ht4	Akt3^tm1Mbb/Akt3⁺	B6.Cg-Akt3^tm1Mbb	MGI:6316994
cn5	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd	MGI:3803972
cn6	Akt1^tm1Pnt/Akt1^tm1Pnt Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0	Not Specified	MGI:3803970
cx7	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804003
cx8	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-PyVT)634Mul/0	involves: 129 * C57BL/6 * FVB/N	MGI:3804008
cx9	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb	involves: 129P2/OlaHsd	MGI:3803968

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	B6.Cg-Akt3^tm1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired discrimination learning ( J:245549 )

• mice exhibit impaired temporal order object discrimination memory

• however, novel object preference is normal, sensorimotor gating is normal, learned fear conditioning and fear extinction are intact, and social functioning is normal

abnormal spatial reference memory ( J:245549 )

• mice exhibit impaired spatial location memory

increased locomotor activity ( J:245549 )

• baseline locomotor activity is increased, with mice being hyperactive and traveling significantly more distance in the border

• however, mice do not show increased anxiety

nervous system

decreased brain size ( J:245549 )

• 24% reduction in brain size

• however, body weight and size is normal

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit higher electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

nervous system

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit higher electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:96823 )

N	• no abnormalities in carbohydrate metabolism

nervous system

decreased brain size ( J:96823 )

• adult brains were 25% smaller than in wildtype, however body size and other organ sizes were normal

• postnatal day 1 homozgyotes displayed a 15% reduction in brain size

• the relative reduction in brain size compared to wildtype continued to increase during the first 3 weeks of life, reaching the same degree as that seen in adults by the end of the third week

• decrease in cell number and a reduction in cell size in the brain

immune system

immune system phenotype ( J:135903 )

N	• no abnormalities in T cell development are observed

Allelic Composition	Akt3^tm1Mbb/Akt3⁺
Genetic Background	B6.Cg-Akt3^tm1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain size ( J:245549 )

• 7% reduction in brain size

Allelic Composition	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Pnt mutation (0 available); any Akt1 mutation (34 available)
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

immune system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

cellular

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

Allelic Composition	Akt1^tm1Pnt/Akt1^tm1Pnt Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Pnt mutation (0 available); any Akt1 mutation (34 available)
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 2.5 fold

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 78.2% compared to 84.6% in wild-type mice

immune system

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 2.5 fold

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 78.2% compared to 84.6% in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 2.5 fold

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 17.5 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 17.5 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 17.5 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:135903 )

• no abnormalities in T cell development are observed

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23