Phenotypes associated with this allele

• Allele Symbol: Itga10^tm1Ref
• Allele Name: targeted mutation 1, Reinhard Fassler
• Allele ID: MGI:3574026
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itga10^tm1Ref/Itga10^tm1Ref	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3574284

Genotype
MGI:3574284

hm1

• Allelic Composition: Itga10^tm1Ref/Itga10^tm1Ref
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

limbs/digits/tail

short femur ( J:96524 )

• the femur is 7-10% shorter in mutants at 12 weeks and 1 year of age

short tibia ( J:96524 )

• the tibia is 7-10% shorter in mutants at 12 weeks and 1 year of age

skeleton

short femur ( J:96524 )

• the femur is 7-10% shorter in mutants at 12 weeks and 1 year of age

short tibia ( J:96524 )

• the tibia is 7-10% shorter in mutants at 12 weeks and 1 year of age

abnormal long bone epiphyseal plate morphology ( J:96524 )

• a few apoptotic chondrocytes are seen in the proliferative and hypertrophic zones of the growth plate compared to none in wild-type mice

• chondrocytes display a G1/S phase transition defect and reduced proliferation most prominently at birth and at 2 weeks of age

decreased width of hypertrophic chondrocyte zone ( J:96524 )

• the hypertrophic zone is shorter consisting of only 2-3 cell layers

abnormal cartilage development ( J:96524 )

• the density of the collagen fibrillar network is slightly reduced and collagen X deposition is seen in the proliferative zone