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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SOD1*G37R)9Dpr
transgene insertion 9, Donald L Price
MGI:3574015
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(SOD1*G37R)9Dpr/0 involves: C3H/HeJ * C57BL/6J MGI:3814059


Genotype
MGI:3814059
tg1
Allelic
Composition
Tg(SOD1*G37R)9Dpr/0
Genetic
Background
involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit vacuoles lesions in the olfactory bulb, the piriform cortex, several thalamic nuclei, some pons neurons, the choroid plexus, and the cerebellar roof nuclei (J:69178)
• mice exhibit vacuoles lesions in the olfactory bulb, the piriform cortex, several thalamic nuclei, some pons neurons, the choroid plexus, and the cerebellar roof nuclei (J:69178)
• at late stages (J:69178)
• at late stages (J:69178)
• motor neuron degeneration is observed in the ventral horns of the lumbar, thoracic, and cervical spinal cord as well as the brain stem (J:69178)
• degeneration is associated with vacuole formation in both dendrites and axons of motor neurons (J:69178)
• motor neuron degeneration is observed in the ventral horns of the lumbar, thoracic, and cervical spinal cord as well as the brain stem (J:69178)
• degeneration is associated with vacuole formation in both dendrites and axons of motor neurons (J:69178)

behavior/neurological
• at 5 to 6 months of age, mice exhibit axial tremors (J:69178)
• at 5 to 6 months of age, mice exhibit axial tremors (J:69178)
• at 5 to 6 months of age, mice exhibit asymmetric weakness of the limbs and when suspended by their tail exhibit difficulties extending and moving hindlimbs (J:69178)
• at 5 to 6 months of age, mice exhibit asymmetric weakness of the limbs and when suspended by their tail exhibit difficulties extending and moving hindlimbs (J:69178)
• at 5 to 6 months of age, mice exhibit decreased spontaneous movement compared to wild-type mice (J:69178)
• at 5 to 6 months of age, mice exhibit decreased spontaneous movement compared to wild-type mice (J:69178)
• eventually mice develop hindlimb paralysis (J:69178)
• eventually mice develop hindlimb paralysis (J:69178)

muscle
• at 5 to 6 months of age, mice exhibit muscle wasting particularly along the flanks (J:69178)
• at 5 to 6 months of age, mice exhibit muscle wasting particularly along the flanks (J:69178)
• mice exhibit spontaneous, positive sharp waves associated with denervation atrophy (J:69178)
• mice exhibit spontaneous, positive sharp waves associated with denervation atrophy (J:69178)

cellular
• motor neurons exhibit mitochondrial degradation (J:69178)
• motor neurons exhibit mitochondrial degradation (J:69178)

growth/size/body
• progressive (J:69178)
• progressive (J:69178)

renal/urinary system
• mice exhibit vacuolization of epithelial cells in the proximal tubules of the kidney (J:69178)
• mice exhibit vacuolization of epithelial cells in the proximal tubules of the kidney (J:69178)

integument
• at 5 to 6 months of age (J:69178)
• at 5 to 6 months of age (J:69178)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:69178





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory