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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2-Obvic1
virus infectivity controller 1
MGI:3573873
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2-Obvic1/H2-Obvic1 B6.I-H2-Obvic1 MGI:6189195
hm2
H2-Obvic1/H2-Obvic1 C3N.I-H2-Obvic1 MGI:6189192
hm3
H2-Obvic1/H2-Obvic1 C.I-H2-Obvic1 MGI:6189197
hm4
H2-Obvic1/H2-Obvic1 I/LnJ MGI:4822379


Genotype
MGI:6189195
hm1
Allelic
Composition
H2-Obvic1/H2-Obvic1
Genetic
Background
B6.I-H2-Obvic1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• virus-neutralizing immune response is generated in response to infection with retroviruses




Genotype
MGI:6189192
hm2
Allelic
Composition
H2-Obvic1/H2-Obvic1
Genetic
Background
C3N.I-H2-Obvic1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• virus-neutralizing immune response is generated in response to infection with retroviruses




Genotype
MGI:6189197
hm3
Allelic
Composition
H2-Obvic1/H2-Obvic1
Genetic
Background
C.I-H2-Obvic1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• virus-neutralizing immune response is generated in response to infection with retroviruses




Genotype
MGI:4822379
hm4
Allelic
Composition
H2-Obvic1/H2-Obvic1
Genetic
Background
I/LnJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Obvic1 mutation (1 available); any H2-Ob mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• although MMTV and MuLV infection can occur, MMTV transmission and mammary tumor induction are blocked and MuLV transmission and virally induced disease are blocked, and these responses are mediated by anti-virion antibodies, require gamma interferon, cytotoxic immune responses, but not interleukin 12

neoplasm
• mammary glands become infected with MMTV but at 1.5 years zero of 24 infected females develop tumors (J:81554)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/17/2022
MGI 6.19
The Jackson Laboratory