Mouse Genome Informatics
hm1
    Airetm1Mmat/Airetm1Mmat
B6.Cg-Airetm1Mmat
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• exhibited similar autoimmune phenotypes as seen in the mixed C57BL/6 and CBA background

endocrine/exocrine glands
• infiltration of many lymphoid cells in the salivary glands

digestive/alimentary system
• infiltration of many lymphoid cells in the salivary glands


Mouse Genome Informatics
hm2
    Airetm1Mmat/Airetm1Mmat
C.Cg-Airetm1Mmat
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• exhibited similar autoimmune phenotypes as seen in the mixed C57BL/6 and CBA background
• Background Sensitivity: demonstrated strong auto-antibodies against gastric mucosa

digestive/alimentary system
• Background Sensitivity: lymphoid cell infiltration in the gastric mucosa


Mouse Genome Informatics
hm3
    Airetm1Mmat/Airetm1Mmat
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• developed autoimmunity against the defined target antigen, spectrin alpha 2 (alpha-fodrin), a ubiquitously expressed actin binding protein

endocrine/exocrine glands
N
• developed Sjogren's syndrome-like pathologic changes in the exocrine organs (J:96580)
• infiltration of many lymphoid cells in the parotid glands
• infiltration of many lymphoid cells in the submandibular glands
• infiltration of many lymphoid cells in the lacrimal glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas
• secretion of tears per unit of mouse body weight was decreased

vision/eye
• infiltration of many lymphoid cells in the lacrimal glands
• secretion of tears per unit of mouse body weight was decreased

reproductive system
• homozygous crossings produced offspring only occasionally

digestive/alimentary system
• infiltration of many lymphoid cells in the parotid glands
• infiltration of many lymphoid cells in the submandibular glands
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas


Mouse Genome Informatics
ht4
    Airetm1Mmat/Airetm2Mmat
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

immune system
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat
• display autoimmune pathology with onset at 4 to 6 weeks of age

endocrine/exocrine glands
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat


Mouse Genome Informatics
cx5
    Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?

involves: BALB/c * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
N
• autoimmune pathology is absent unlike in mice not carrying Tg(TcraTcrb)425Cbn (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

hematopoietic system
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat

endocrine/exocrine glands
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat