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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Airetm1Mmat
targeted mutation 1, Mitsuru Matsumoto
MGI:3573749
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Airetm1Mmat/Airetm1Mmat B6.Cg-Airetm1Mmat MGI:3576483
hm2
Airetm1Mmat/Airetm1Mmat C.Cg-Airetm1Mmat MGI:3576481
hm3
Airetm1Mmat/Airetm1Mmat involves: C57BL/6 * CBA MGI:3576479
ht4
Airetm1Mmat/Airetm2Mmat involves: C57BL/6 * CBA MGI:3818935
cx5
Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?
involves: BALB/c * C57BL/6 * CBA MGI:3818937


Genotype
MGI:3576483
hm1
Allelic
Composition
Airetm1Mmat/Airetm1Mmat
Genetic
Background
B6.Cg-Airetm1Mmat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (0 available); any Aire mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• exhibited similar autoimmune phenotypes as seen in the mixed C57BL/6 and CBA background (J:96580)
• exhibited similar autoimmune phenotypes as seen in the mixed C57BL/6 and CBA background (J:96580)

endocrine/exocrine glands
• infiltration of many lymphoid cells in the salivary glands (J:96580)
• infiltration of many lymphoid cells in the salivary glands (J:96580)

digestive/alimentary system
• infiltration of many lymphoid cells in the salivary glands (J:96580)
• infiltration of many lymphoid cells in the salivary glands (J:96580)




Genotype
MGI:3576481
hm2
Allelic
Composition
Airetm1Mmat/Airetm1Mmat
Genetic
Background
C.Cg-Airetm1Mmat
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (0 available); any Aire mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• exhibited similar autoimmune phenotypes as seen in the mixed C57BL/6 and CBA background (J:96580)
• Background Sensitivity: demonstrated strong auto-antibodies against gastric mucosa (J:96580)
• exhibited similar autoimmune phenotypes as seen in the mixed C57BL/6 and CBA background (J:96580)
• Background Sensitivity: demonstrated strong auto-antibodies against gastric mucosa (J:96580)

digestive/alimentary system
• Background Sensitivity: lymphoid cell infiltration in the gastric mucosa (J:96580)
• Background Sensitivity: lymphoid cell infiltration in the gastric mucosa (J:96580)




Genotype
MGI:3576479
hm3
Allelic
Composition
Airetm1Mmat/Airetm1Mmat
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (0 available); any Aire mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• developed autoimmunity against the defined target antigen, spectrin alpha 2 (alpha-fodrin), a ubiquitously expressed actin binding protein (J:96580)
• developed autoimmunity against the defined target antigen, spectrin alpha 2 (alpha-fodrin), a ubiquitously expressed actin binding protein (J:96580)

endocrine/exocrine glands
N
• developed Sjogren's syndrome-like pathologic changes in the exocrine organs (J:96580)
• developed Sjogren's syndrome-like pathologic changes in the exocrine organs (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)

vision/eye
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• infiltration of many lymphoid cells in the lacrimal glands (J:96580)
• secretion of tears per unit of mouse body weight was decreased (J:96580)
• secretion of tears per unit of mouse body weight was decreased (J:96580)

reproductive system
• homozygous crossings produced offspring only occasionally (J:96580)
• homozygous crossings produced offspring only occasionally (J:96580)

digestive/alimentary system
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the parotid glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• infiltration of many lymphoid cells in the submandibular glands (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)
• in 1 of 10 mutants, lymphoid cell infiltration was observed in either the stomach or pancreas (J:96580)




Genotype
MGI:3818935
ht4
Allelic
Composition
Airetm1Mmat/Airetm2Mmat
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (0 available); any Aire mutation (11 available)
Airetm2Mmat mutation (1 available); any Aire mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)

immune system
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)
• display autoimmune pathology with onset at 4 to 6 weeks of age (J:141379)
• display autoimmune pathology with onset at 4 to 6 weeks of age (J:141379)

endocrine/exocrine glands
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)




Genotype
MGI:3818937
cx5
Allelic
Composition
Airetm1Mmat/Airetm2Mmat
Tg(TcraTcrb)425Cbn/?
Genetic
Background
involves: BALB/c * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1Mmat mutation (0 available); any Aire mutation (11 available)
Airetm2Mmat mutation (1 available); any Aire mutation (11 available)
Tg(TcraTcrb)425Cbn mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• autoimmune pathology is absent unlike in mice not carrying Tg(TcraTcrb)425Cbn (J:141379)
• autoimmune pathology is absent unlike in mice not carrying Tg(TcraTcrb)425Cbn (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)

hematopoietic system
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)

endocrine/exocrine glands
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)
• GFP expressing cells are less complex in shape compared to GFP expressing cells in mice with one wild type allele (J:141379)
• distribution of GFP expressing cells is altered similar to mice homozygous for Airetm2Mmat (J:141379)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory