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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dmdtm1.1Khan
targeted mutation 1.1, Kazunori Hanaoka
MGI:3531484
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ot1
Dmdtm1.1Khan/Y involves: C57BL/6 * CBA MGI:3573782


Genotype
MGI:3573782
ot1
Allelic
Composition
Dmdtm1.1Khan/Y
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdtm1.1Khan mutation (0 available); any Dmd mutation (156 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• severe muscular hypertrophy and dystrophy were observed in the skeletal muscle and diaphragm
• degenerating muscle fibers with cellular infiltration and regenerated muscle appeared at 4 weeks of age
• extensive myofiber degeneration in diaphragm muscle at 4 weeks of age
• frequent muscle fiber necrosis peaking in 3-4 weeks old mice was observed

reproductive system
• hemizygous males were viable and normal in body size and external appearance, but they did not reproduced despite intensive mating

Mouse Models of Human Disease
OMIM ID Ref(s)
Muscular Dystrophy, Duchenne Type; DMD 310200 J:96210





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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory