About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pou5f1tm1.1Scho
targeted mutation 1.1, Hans R Shoeler
MGI:3531175
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Alpltm1(cre)Nagy/Alpl+
Pou5f1tm1Scho/Pou5f1tm1.1Scho
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3579642


Genotype
MGI:3579642
cn1
Allelic
Composition
Alpltm1(cre)Nagy/Alpl+
Pou5f1tm1Scho/Pou5f1tm1.1Scho
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Pou5f1tm1.1Scho mutation (0 available); any Pou5f1 mutation (82 available)
Pou5f1tm1Scho mutation (1 available); any Pou5f1 mutation (82 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• variable depletion of spermatogenic cells is seen with testes containing both germ cell free seminiferous tubules and unaffected tubules
• the percentage of germ cell free tubules varied from 30% to 100%; however unlike females gem cell depletion did no increase with age
• at E10.5 and E12.5 the late migratory and postmigratory primordial germ cell populations are reduced; however the size of the premigratory (E6.5) and early migratory (E9.5) primordial germ cell populations are normal
• up to 70% of primordial germ cells undergo apoptosis before colonizing the gonadal ridges

reproductive system
• variable depletion of spermatogenic cells is seen with testes containing both germ cell free seminiferous tubules and unaffected tubules
• the percentage of germ cell free tubules varied from 30% to 100%; however unlike females gem cell depletion did no increase with age
• at E10.5 and E12.5 the late migratory and postmigratory primordial germ cell populations are reduced; however the size of the premigratory (E6.5) and early migratory (E9.5) primordial germ cell populations are normal
• up to 70% of primordial germ cells undergo apoptosis before colonizing the gonadal ridges
• at 3 weeks of age the number of primordial follicles is reduced 25 - 100-fold
• at 6 weeks of age hardly any primordial follicles and very few growing follicles are seen
• after 6 weeks of age ovarian follicles are mostly absent
• seminiferous tubules lacking germ cells are reduced in diameter
• seen around seminiferous tubules lacking germ cells
• fertility is variably impaired depending on the efficiency of Cre recombination (averaging about 60%)
• males that do produce offspring pass on the unrecombined allele

endocrine/exocrine glands
• at 3 weeks of age the number of primordial follicles is reduced 25 - 100-fold
• at 6 weeks of age hardly any primordial follicles and very few growing follicles are seen
• after 6 weeks of age ovarian follicles are mostly absent
• seminiferous tubules lacking germ cells are reduced in diameter
• seen around seminiferous tubules lacking germ cells

embryo
• clusters of apoptotic primordial germ cells are detected on the genital ridge at E10.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory