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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Camk2a-cre)CW2Stl
transgene insertion CW2, Susumu Tonegawa
MGI:3530562
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ppp3r1tm1Stl/Ppp3r1tm1Stl
Tg(Camk2a-cre)CW2Stl/0
C57BL/6-Ppp3r1tm1Stl Tg(Camk2a-cre)CW2Stl MGI:3530740
cn2
Cacna1gtm1Stl/Cacna1gtm1Stl
Tg(Camk2a-cre)CW2Stl/0
involves: C57BL/6 MGI:3531191


Genotype
MGI:3530740
cn1
Allelic
Composition
Ppp3r1tm1Stl/Ppp3r1tm1Stl
Tg(Camk2a-cre)CW2Stl/0
Genetic
Background
C57BL/6-Ppp3r1tm1Stl Tg(Camk2a-cre)CW2Stl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp3r1tm1Stl mutation (1 available); any Ppp3r1 mutation (27 available)
Tg(Camk2a-cre)CW2Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• appear normal and healthy, but prone to sudden death, with ~50% dead by 6 months of age

behavior/neurological
• decreased working/episodic-like memory in delayed matching-to-place test, however memory extinction are normal
• impaired latent inhibition in cued testing; however motor coordination, pain sensitivity, and cued fear conditioning are normal
• reduced spatial working memory in radial maze test, however in a morris water maze test spatial reference memory appeared normal
• nests poorly formed

nervous system
• significantly lower prepulse inhibition
• seen in Schaffer collateral-CA1 synapse in hippocampal slices and at frequencies where LTD and LTP compete LTP is favored

growth/size/body
• 12% smaller than wild-type littermates

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:73203 , J:84640




Genotype
MGI:3531191
cn2
Allelic
Composition
Cacna1gtm1Stl/Cacna1gtm1Stl
Tg(Camk2a-cre)CW2Stl/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cacna1gtm1Stl mutation (1 available); any Cacna1g mutation (59 available)
Tg(Camk2a-cre)CW2Stl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• no disruption of sleep patterns or reduction in total sleep are seen





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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory