All Phenotypes Fancd2<Gt(OST57859)Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fancd2^{Gt(OST57859)Lex}
gene trap OST57859, Lexicon Genetics
MGI:3530554

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}	involves: 129S5/SvEvBrd	MGI:6828596
hm2	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}	involves: 129S5/SvEvBrd * C57BL/6	MGI:3838390
cx3	Fan1^tm1.1Jrou/Fan1^tm1.1Jrou Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}	involves: 129P2/OlaHsd * 129S5/SvEvBrd	MGI:5897799
cx4	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex} Usp1^tm1.1Ada/Usp1^tm1.1Ada	involves: 129S5/SvEvBrd * C57BL/6	MGI:3838391
cx5	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex} Fanci^tm1.1Itl/Fanci^tm1.1Itl	involves: 129S5/SvEvBrd * C57BL/6J * CBA	MGI:6828597

Allelic Composition	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}
Genetic Background	involves: 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2^{Gt(OST57859)Lex} mutation (0 available); any Fancd2 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:285384 )

• reduced colony forming unit cells

thrombocytopenia ( J:285384 )

decreased hematopoietic stem cell number ( J:285384 )

cellular

increased cellular sensitivity to DNA damaging agents ( J:285384 )

• bone marrow hematopoietic progenitor cells are hypersensitive to mitomycin C compared with wild-type cells

Allelic Composition	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2^{Gt(OST57859)Lex} mutation (0 available); any Fancd2 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:146616 )

• phenotype is stated to be similar to that of Fancd2^tm1Hou homozygotes; however no data is presented in J:146616

growth/size/body

decreased body weight ( J:146616 )

postnatal growth retardation ( J:146616 )

fetal growth retardation ( J:146616 )

endocrine/exocrine glands

decreased mature ovarian follicle number ( J:146616 )

abnormal seminiferous tubule morphology ( J:146616 )

small testis ( J:146616 )

reproductive system

oligozoospermia ( J:146616 )

abnormal spermatocyte morphology ( J:146616 )

decreased mature ovarian follicle number ( J:146616 )

abnormal seminiferous tubule morphology ( J:146616 )

small testis ( J:146616 )

abnormal male meiosis ( J:146616 )

neoplasm

increased adenoma incidence ( J:146616 )

increased carcinoma incidence ( J:146616 )

vision/eye

microphthalmia ( J:146616 )

cellular

oligozoospermia ( J:146616 )

abnormal spermatocyte morphology ( J:146616 )

Allelic Composition	Fan1^tm1.1Jrou/Fan1^tm1.1Jrou Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex}
Genetic Background	involves: 129P2/OlaHsd * 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fan1^tm1.1Jrou mutation (0 available); any Fan1 mutation (98 available)
Fancd2^{Gt(OST57859)Lex} mutation (0 available); any Fancd2 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:232403 )

• increase in sensitivity to mitomycin C compared to either single homozygote

Allelic Composition	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex} Usp1^tm1.1Ada/Usp1^tm1.1Ada
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2^{Gt(OST57859)Lex} mutation (0 available); any Fancd2 mutation (81 available)
Usp1^tm1.1Ada mutation (0 available); any Usp1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased cellular sensitivity to ionizing radiation ( J:146616 )

• bone marrow cells have decreased survival after exposure to ionizing radiation compared to controls that are homozygote null for just one allele

induced chromosome breakage ( J:146616 )

• bone marrow cell are also hypersensitive to mitomycin C treatment (MMC) with with increased numbers of chromosome breaks and decreased survival compared to controls that are homozygote null for just one allele

endocrine/exocrine glands

ovary atrophy ( J:146616 )

• female mice have severe atrophy of the ovaries

reproductive system

ovary atrophy ( J:146616 )

• female mice have severe atrophy of the ovaries

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Fanconi anemia complementation group D2		DOID:0111083	OMIM:227646	J:146616

Allelic Composition	Fancd2^{Gt(OST57859)Lex}/Fancd2^{Gt(OST57859)Lex} Fanci^tm1.1Itl/Fanci^tm1.1Itl
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fancd2^{Gt(OST57859)Lex} mutation (0 available); any Fancd2 mutation (81 available)
Fanci^tm1.1Itl mutation (0 available); any Fanci mutation (200 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:285384 )

• fewer than expected mice are born

hematopoietic system

abnormal bone marrow cell morphology/development ( J:285384 )

• reduced colony forming unit cells as in single knock-outs

thrombocytopenia ( J:285384 )

• as in single knock-outs

decreased hematopoietic stem cell number ( J:285384 )

• worse than in single knock-outs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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