Phenotypes associated with this allele

• Allele Symbol: Cacna1g^tm1.1Stl
• Allele Name: targeted mutation 1.1, Susumu Tonegawa
• Allele ID: MGI:3530501
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cacna1g^tm1.1Stl/Cacna1g^tm1.1Stl	involves: C57BL/6	MGI:3531190

Genotype
MGI:3531190

hm1

• Allelic Composition: Cacna1g^tm1.1Stl/Cacna1g^tm1.1Stl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:96099 )

• a slight decrease in activity during the dark period is seen

abnormal sleep duration ( J:96099 )

• during the dark period mutants have a longer latency to sleep (226 min compared to 28 min for wild-type) and overall the total amount of non-REM sleep is reduced (9h 54min compared to 11h 24min for wild-type

abnormal sleep pattern ( J:96099 )

• during the dark period mutants have a longer latency to sleep (226 min compared to 28 min for wild-type) and overall the total amount of non-REM sleep is reduced (9h 54min compared to 11h 24min for wild-type

• increased delta wave power is seen during non-REM sleep

fragmentation of sleep/wake states ( J:96099 )

• during the light period mutants display fragmented sleep with frequent brief wakenings, more total wake bouts, and non-REM bouts are much shorter

nervous system

abnormal action potential ( J:96099 )

• transient or repeated hyperpolarization fails to inhibit action-potential firing

impaired ability to fire action potentials ( J:96099 )

• tonic hyperpolarization fails to evoke action-potential firing in mutant thalamic projection neurons