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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(HLA-DRB1)31Dmz
transgene insertion 31, Dennis M Zaller
MGI:3529465
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL MGI:3639133
cx2
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * CBA * SJL MGI:3639130


Genotype
MGI:3639133
cx1
Allelic
Composition
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Gru mutation (12 available); any H2-Ab1 mutation (34 available)
Tg(HLA-DQA1,HLA-DQB1)1Dv mutation (1 available)
Tg(HLA-DRB1)31Dmz mutation (1 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line (J:68641)
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)
• incidence of diabetes (blood glucose >250 mg/dl; 5/22, 23%) is lowered from incidence in MHC class II-deficient mice expressing the DQ8 transgene (73%) and similar to deficient mice transgenic for DR4 (J:68641)
• incidence of diabetes (blood glucose >250 mg/dl; 5/22, 23%) is lowered from incidence in MHC class II-deficient mice expressing the DQ8 transgene (73%) and similar to deficient mice transgenic for DR4 (J:68641)

endocrine/exocrine glands
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)

hematopoietic system
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line (J:68641)
• coexpression of DR4 and DQ8 transgenes increases CD4+ T cell numbers 2-fold compared to either DR4 or DQ8 single transgenic line (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)

digestive/alimentary system
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:68641




Genotype
MGI:3639130
cx2
Allelic
Composition
H2-Ab1tm1Gru/H2-Ab1tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1tm1Gru mutation (12 available); any H2-Ab1 mutation (34 available)
Tg(HLA-DRB1)31Dmz mutation (1 available)
Tg(Ins2-CD80)3B7Flv mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)

immune system
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice (J:68641)
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)
• incidence of diabetes (5/20) is lower than in MHC class II-deficient mice expressing the DQ8 transgene where incidence is 3-fold higher (73%) (J:68641)
• incidence of diabetes (5/20) is lower than in MHC class II-deficient mice expressing the DQ8 transgene where incidence is 3-fold higher (73%) (J:68641)

hematopoietic system
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice (J:68641)
• expression of the DR4 transgene increases CD4+ T cell numbers compared to the H2-Ab1-deficient Tg(Ins2-CD80)3B7Flv mice (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)
• there are fewer CD8+ T cells in pancreatic infiltrates than in MHC class II-deficient mice expressing only DQ8 (J:68641)

digestive/alimentary system
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)
• transgenic mice develop sialadenitis and severity is associated with diabetes development (J:68641)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:68641





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory