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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adcy10tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3529121
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adcy10tm1Lex/Adcy10tm1Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3038845
hm2
Adcy10tm1Lex/Adcy10tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609673


Genotype
MGI:3038845
hm1
Allelic
Composition
Adcy10tm1Lex/Adcy10tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy10tm1Lex mutation (2 available); any Adcy10 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• over time, even cAMP analog-rescued mutant sperm fold back 180 degrees until the head and midpiece form a hairpin configuration with the rest of the sperm flagellum
• even after motility is restored with a cAMP analogue, ~100% of mutant sperm show flagellar angularity
• the flagellum begins to bend at the annulus (the midpiece-principal piece junction) within 10 min of isolation
(J:88649)
(J:100583)
• in an in vitro fertilization assay mutant sperm can induce cumulus release but do not produce any two-cell stage embryos (J:88649)
• restoration of sperm motility has little effect on fertility (J:100583)
• even cAMP analog-rescued mutant sperm are unable to fertilize eggs in vitro
• sperm fail to become hyperactive even after motility is restored with cAMP
• mutant sperm appear able to achieve no forward movement and produce only a trembling movement of the midpiece (J:88649)
• motility could be restored in vitro by loading sperm with a cAMP analogue (J:88649)
(J:100583)

cellular
• over time, even cAMP analog-rescued mutant sperm fold back 180 degrees until the head and midpiece form a hairpin configuration with the rest of the sperm flagellum
• even after motility is restored with a cAMP analogue, ~100% of mutant sperm show flagellar angularity
• the flagellum begins to bend at the annulus (the midpiece-principal piece junction) within 10 min of isolation




Genotype
MGI:3609673
hm2
Allelic
Composition
Adcy10tm1Lex/Adcy10tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy10tm1Lex mutation (2 available); any Adcy10 mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• seen in females

cardiovascular system
• slight increase seen in both males and females





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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory