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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ikbkbtm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528765
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ikbkbtm1Lex/Ikbkbtm1Lex
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S/SvEvBrd MGI:4457386
cn2
 		Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Ikbkbtm1Lex/Ikbkbtm1Lex 		involves: 129S/SvEvBrd MGI:3814551


Genotype
MGI:4457386
cn1
Allelic
Composition		 Ikbkbtm1Lex/Ikbkbtm1Lex
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Lex mutation (1 available); any Ikbkb mutation (54 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
impaired macrophage chemotaxis ( J:159873 )
• macrophages exhibit decreased chemotaxis in response to HMGB1 compared with wild-type cells
• however, chemotaxis response to C5a is normal
impaired neutrophil chemotaxis ( J:159873 )
• neutrophils exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells
• however, chemotaxis response to TNF-alpha is normal
impaired neutrophil recruitment ( J:159873 )
• following intraperitoneal injection of HMGB1, neutrophil recruitment is decreased compared to in similarly treated wild-type mice
• however, recruitment following injection of TNF-alpha is normal

cellular
impaired macrophage chemotaxis ( J:159873 )
• macrophages exhibit decreased chemotaxis in response to HMGB1 compared with wild-type cells
• however, chemotaxis response to C5a is normal
impaired neutrophil chemotaxis ( J:159873 )
• neutrophils exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells
• however, chemotaxis response to TNF-alpha is normal

hematopoietic system
impaired macrophage chemotaxis ( J:159873 )
• macrophages exhibit decreased chemotaxis in response to HMGB1 compared with wild-type cells
• however, chemotaxis response to C5a is normal
impaired neutrophil chemotaxis ( J:159873 )
• neutrophils exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells
• however, chemotaxis response to TNF-alpha is normal
impaired neutrophil recruitment ( J:159873 )
• following intraperitoneal injection of HMGB1, neutrophil recruitment is decreased compared to in similarly treated wild-type mice
• however, recruitment following injection of TNF-alpha is normal




Genotype
MGI:3814551
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Ikbkbtm1Lex/Ikbkbtm1Lex
Genetic
Background		 involves: 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Ikbkbtm1Lex mutation (1 available); any Ikbkb mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal fibroblast migration ( J:159873 )
• following tamoxifen-treatment, mouse embryonic fibroblasts (MEFs) exhibit random migration in response to an HMGB1 gradient unlike wild-type cells
decreased fibroblast cell migration ( J:159873 )
• 30 to 60 minutes after exposure to HMGB1, tamoxifen-treated MEFs exhibit reduced migration velocity compared with wild-type mice
decreased fibroblast chemotaxis ( J:159873 )
• following tamoxifen-treatment, MEFs exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells
• however, chemotaxis in response to PDGF is normal and chemotaxis is rescued by over expression of Nfkb2




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory