About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp53tm3.1Glo
targeted mutation 3.1, Guillermina Lozano
MGI:3528279
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp53tm3.1Glo/Trp53tm3.1Glo B6.129S7-Trp53tm3.1Glo MGI:3722620
ht2
Trp53tm3.1Glo/Trp53+ B6.129S7-Trp53tm3.1Glo MGI:3576493
ht3
Trp53tm1Tyj/Trp53tm3.1Glo involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:3722619
ht4
Trp53tm3.1Glo/Trp53tm4Glo involves: 129S7/SvEvBrd * C57BL/6 MGI:5000508
cn5
Trp53tm3.1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:5000509
cx6
Mdm2tm3.1Glo/Mdm2tm3.1Glo
Trp53tm3.1Glo/Trp53+
B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo MGI:4835498
cx7
Mdm2tm4.1Glo/Mdm2tm4.1Glo
Trp53tm3.1Glo/Trp53+
B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo MGI:4835500
cx8
Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm3.1Glo/Trp53tm3.1Glo
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5142303
cx9
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53tm4Glo
involves: 129S7/SvEvBrd * C57BL/6 MGI:5000504
cx10
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53+
involves: 129S7/SvEvBrd * C57BL/6 MGI:3576494


Genotype
MGI:3722620
hm1
Allelic
Composition
Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic
Background
B6.129S7-Trp53tm3.1Glo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous mutants die between 50 to 250 days after birth, however this survival curve is no different from homozygous null Trp53 mice homozygous mutants die between 50 to 250 days after birth, however this survival curve is no different from homozygous null Trp53 mice

neoplasm
• 70% of mice develop lymphomas
• 29% of mice develop sacromas

homeostasis/metabolism
• DNA synthesis rates for mouse fibroblast cells continue to synthesize DNA after 10 days in culture whereas MEFs from a Trp53tm1Tyj homozygote are quiescent at day 6

cellular
• DNA synthesis rates for mouse fibroblast cells continue to synthesize DNA after 10 days in culture whereas MEFs from a Trp53tm1Tyj homozygote are quiescent at day 6
• at day 4 of culture, mouse embryonic fibroblast (MEF)cells reach a higher saturation concentration than do MEFs from a Trp53tm1Tyj homozygote




Genotype
MGI:3576493
ht2
Allelic
Composition
Trp53tm3.1Glo/Trp53+
Genetic
Background
B6.129S7-Trp53tm3.1Glo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• heterozygous mutants die between 150 to750 days after birth, however this survival curve is no different from heterozygous Trp53 mice

neoplasm
• the osteosarcomas and carcinomas of heterozygous mutants metastasized when compared to heterozygous Trp53tm1Tyj mice
• 31.5% of heterozygous mutants developed lymphomas
• 15.5% of heterozygous mutants developed carcinomas, which are rare in homozygotes
• 53% of heterozygous mutants developed sarcomas

cellular
• higher DNA synthesis in MEFs with cells continuing to synthesize DNA between days 6 and 10 of culture compared to wildtype or heterozygous or homozygous Trp53tm1Tyj MEFs which reached a quiescent state at day 6 and did not reenter the cell cycle
• irradiated E13.5 heterozygous embryos showed no evidence of apoptosis in the hypothalamus compared to wildtype and heterozygous Trp53tm1Tyj mutants that showed a high number of apoptotic cells
• MEFs initially did not show any significant differences in growth rate but by day 4, grew more rapidly than wildtype or heterozygous or homozygous null Trp53tm1Tyj MEFs and reached a much higher saturation density

Mouse Models of Human Disease
OMIM ID Ref(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:95318




Genotype
MGI:3722619
ht3
Allelic
Composition
Trp53tm1Tyj/Trp53tm3.1Glo
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (145 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice do not survive past 300 days compared to Trp53tm1Tyj heterozygotes and Trp53tm3.1Glo heterozygotes that live to 900 days




Genotype
MGI:5000508
ht4
Allelic
Composition
Trp53tm3.1Glo/Trp53tm4Glo
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 160 days due to tumor development

neoplasm
• tumors exhibit interstitial inflammatory cells unlike in tumors from Trp53tm3.1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
• in 60% of mice (including T cell, diffuse, and large cell)
• in 37% of mice (including angiosarcoma, spindle-cell, and giant-cell)




Genotype
MGI:5000509
cn5
Allelic
Composition
Trp53tm3.1Glo/Trp53tm4Glo
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (6 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• tamoxifen-treated mice survive longer than Trp53tm3.1Glo/Trp53tm4Glo mice

neoplasm
• tamoxifen-treated lymphomas exhibit increased apoptosis response compared with tumors from Trp53tm1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
• 3 of 5 tamoxifen-treated lymphomas exhibit senescence unlike in tumors from Trp53tm1Glo/Trp53tm4Glo Tg(CAG-cre/Esr1*)5Amc mice
• tamoxifen-treated angiosarcomas and lymphomas exhibit senescence
• tamoxifen-treated mice exhibit little to no tumor growth unlike in control mice




Genotype
MGI:4835498
cx6
Allelic
Composition
Mdm2tm3.1Glo/Mdm2tm3.1Glo
Trp53tm3.1Glo/Trp53+
Genetic
Background
B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm3.1Glo mutation (0 available); any Mdm2 mutation (34 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument

skeleton

endocrine/exocrine glands

muscle

liver/biliary system

respiratory system

mortality/aging
• overall survival is reduced relative to mice homozygous for Mdm2tm4.1Glo and heterozygous for Trp53 tm3.1Glo

cellular
• in the thymus following a low dose of IR radiation compared to mice homozygous for Mdm2tm4.1Glo and heterozygous for Trp53tm3.1Glo

neoplasm
• accelerated tumor onset relative to mice homozygous for Mdm2tm4.1Glo and heterozygous for Trp53 tm3.1Glo
• the tumor spectrum is also altered relative to mice homozygous for Mdm2tm4.1Glo and heterozygous for Trp53 tm3.1Glo
• mice develop multiple primary tumors
• salivary carcinoma in 1 mouse
• undefined carcinomas are also reported
• soft tissue sarcoma
• chondrosarcoma in 1 mouse
• squamous cell papilloma in 1 mouse




Genotype
MGI:4835500
cx7
Allelic
Composition
Mdm2tm4.1Glo/Mdm2tm4.1Glo
Trp53tm3.1Glo/Trp53+
Genetic
Background
B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm4.1Glo mutation (0 available); any Mdm2 mutation (34 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:5142303
cx8
Allelic
Composition
Mdm4tm3.1Glo/Mdm4tm3.1Glo
Trp53tm3.1Glo/Trp53tm3.1Glo
Genetic
Background
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm4tm3.1Glo mutation (0 available); any Mdm4 mutation (177 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike mice homozygous the Mdm4 allele alone, double mutant mice are viable




Genotype
MGI:5000504
cx9
Allelic
Composition
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53tm4Glo
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (34 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
Trp53tm4Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• lethality observed in Mdm2tm1Glo homozygotes is completely rescued with mice surviving beyond 5 weeks




Genotype
MGI:3576494
cx10
Allelic
Composition
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdm2tm1Glo mutation (0 available); any Mdm2 mutation (34 available)
Trp53tm3.1Glo mutation (0 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no newborn mice are recovered





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory