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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dok1tm1Yyam
targeted mutation 1, Yuji Yamanashi
MGI:3527415
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dok1tm1Yyam/Dok1tm1Yyam B6.129S4-Dok1tm1Yyam MGI:3804059
hm2
Dok1tm1Yyam/Dok1tm1Yyam involves: 129S4/SvJae * C57BL/6 MGI:3574535
cx3
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
B6.129-Dok1tm1Yyam Dok2tm1Yyam MGI:3574536
cx4
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4829895
cx5
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4829896
cx6
Dok1tm1Yyam/Dok1tm1Yyam
Ppargtm1Laz/Ppargtm1Laz
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:3804060
cx7
Dok1tm1Yyam/Dok1tm1Yyam
Tg(BCR/ABL1)5Hhi/0
involves: C57BL/6 MGI:3574537
cx8
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
involves: C57BL/6 MGI:3574538


Genotype
MGI:3804059
hm1
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Genetic
Background
B6.129S4-Dok1tm1Yyam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• body weight of mice are 10% lower than controls despite being similar in length
• mice weigh over 20% less than controls when fed a high fat diet for 12 weeks

adipose tissue
• mice have significantly less BAT than controls as measured by weight
• size of adipocytes is smaller compared to wild-type controls when both are fed a chow or a high-fat diet
• mouse embryonic fibroblasts are impaired in their ability to develop into adipocyte-like cells
• there are significantly less amounts of epididymal fat in these mice
• there are significantly less amounts of inguinal fat in these mice
• percent body fat is reduced by more than 25% on both chow and high-fat diets

homeostasis/metabolism
• insulin levels are two-thirds lower than control in mice fed a high fat diet
• plasma insulin levels are also two-thirds lower in these mice when given a bolus of glucose
• mice fed a high-fat diet almost half the serum levels of leptin compared to wild-type mice
• mice have an increased oxygen consumption (normalized for body weight) when fed a high-fat diet
• mice have higher tolerance to glucose challenge after being fed a high-fat diet compared to controls
• mice fed a high fat diet higher drops in blood sugar upon insulin challenge compared to wild-type mice fed the same diet
• mice have a lower score than controls on the homeostasis model assessment measure of insulin sensitivity
• mice fed a high-fat diet have higher serum levels of adiponectin




Genotype
MGI:3574535
hm2
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen

hematopoietic system
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen




Genotype
MGI:3574536
cx3
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Genetic
Background
B6.129-Dok1tm1Yyam Dok2tm1Yyam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• double homozygotes develop myeloproliferative disease by about 1 year of age with atypical myeloid cells resembling myelomonocytic cells
• cellular infiltrations of granulocytes and lymphocytes are seen in several tissues
• about half of the double homozygotes with myeloproliferative disease develop histiocytic sarcoma of macrophage origin

hematopoietic system
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors
• hyperplasia of myeloid precursors
• hyperplasia of megakaryocytes
• hyperplasia of erythroblasts
• leukocyte numbers in the peripheral blood are significantly higher
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines

immune system
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors
• hyperplasia of myeloid precursors
• leukocyte numbers in the peripheral blood are significantly higher
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Chronic Myeloid; CML 608232 J:95335




Genotype
MGI:4829895
cx4
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type

hematopoietic system
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type




Genotype
MGI:4829896
cx5
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (5 available)
Dok3tm1Brs mutation (0 available); any Dok3 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• nearly half (15 of 33) of the mice died between 14?51 weeks after birth

neoplasm
• a markedly high incidence (24 of 41) of large cell tumors at 65 weeks of age
• abnormal proliferative cells with histiocytic morphology and cell surface markers in the bone marrow, spleen, and/or liver
• the histiocytic sarcoma is highly invasive and transplantable

hematopoietic system
• abnormal Mac-2-positive macrophages in the lung
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response

immune system
• abnormal Mac-2-positive macrophages in the lung
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response




Genotype
MGI:3804060
cx6
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Ppargtm1Laz/Ppargtm1Laz
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
Ppargtm1Laz mutation (1 available); any Pparg mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
N
• the characteristic resistance of Dok1tm1Yyam homozygotes to a high fat diet in terms of weight gain, adipose tissue growth, and rises in serum levels of leptin and insulin are normalized when mice are on a Pparg homozygote background
• size of adipocytes is smaller compared to wild-type controls when a high-fat diet




Genotype
MGI:3574537
cx7
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Tg(BCR/ABL1)5Hhi/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
Tg(BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Chronic Myeloid; CML 608232 J:95335




Genotype
MGI:3574538
cx8
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (3 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (5 available)
Tg(BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Chronic Myeloid; CML 608232 J:95335





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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory