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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dok1tm1Yyam
targeted mutation 1, Yuji Yamanashi
MGI:3527415
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dok1tm1Yyam/Dok1tm1Yyam B6.129S4-Dok1tm1Yyam MGI:3804059
hm2
Dok1tm1Yyam/Dok1tm1Yyam involves: 129S4/SvJae * C57BL/6 MGI:3574535
cx3
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
B6.129-Dok1tm1Yyam Dok2tm1Yyam MGI:3574536
cx4
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4829895
cx5
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4829896
cx6
Dok1tm1Yyam/Dok1tm1Yyam
Ppargtm1Laz/Ppargtm1Laz
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 MGI:3804060
cx7
Dok1tm1Yyam/Dok1tm1Yyam
Tg(BCR/ABL1)5Hhi/0
involves: C57BL/6 MGI:3574537
cx8
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
involves: C57BL/6 MGI:3574538


Genotype
MGI:3804059
hm1
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Genetic
Background
B6.129S4-Dok1tm1Yyam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• percent body fat is reduced by more than 25% on both chow and high-fat diets (J:133566)
• percent body fat is reduced by more than 25% on both chow and high-fat diets (J:133566)
• body weight of mice are 10% lower than controls despite being similar in length (J:133566)
• body weight of mice are 10% lower than controls despite being similar in length (J:133566)
• mice weigh over 20% less than controls when fed a high fat diet for 12 weeks (J:133566)
• mice weigh over 20% less than controls when fed a high fat diet for 12 weeks (J:133566)

adipose tissue
• mice have significantly less BAT than controls as measured by weight (J:133566)
• mice have significantly less BAT than controls as measured by weight (J:133566)
• percent body fat is reduced by more than 25% on both chow and high-fat diets (J:133566)
• percent body fat is reduced by more than 25% on both chow and high-fat diets (J:133566)
• size of adipocytes is smaller compared to wild-type controls when both are fed a chow or a high-fat diet (J:133566)
• mouse embryonic fibroblasts are impaired in their ability to develop into adipocyte-like cells (J:133566)
• size of adipocytes is smaller compared to wild-type controls when both are fed a chow or a high-fat diet (J:133566)
• mouse embryonic fibroblasts are impaired in their ability to develop into adipocyte-like cells (J:133566)
• there are significantly less amounts of epididymal fat in these mice (J:133566)
• there are significantly less amounts of epididymal fat in these mice (J:133566)
• there are significantly less amounts of inguinal fat in these mice (J:133566)
• there are significantly less amounts of inguinal fat in these mice (J:133566)

homeostasis/metabolism
• insulin levels are two-thirds lower than control in mice fed a high fat diet (J:133566)
• plasma insulin levels are also two-thirds lower in these mice when given a bolus of glucose (J:133566)
• insulin levels are two-thirds lower than control in mice fed a high fat diet (J:133566)
• plasma insulin levels are also two-thirds lower in these mice when given a bolus of glucose (J:133566)
• mice fed a high-fat diet almost half the serum levels of leptin compared to wild-type mice (J:133566)
• mice fed a high-fat diet almost half the serum levels of leptin compared to wild-type mice (J:133566)
• mice have an increased oxygen consumption (normalized for body weight) when fed a high-fat diet (J:133566)
• mice have an increased oxygen consumption (normalized for body weight) when fed a high-fat diet (J:133566)
• mice have higher tolerance to glucose challenge after being fed a high-fat diet compared to controls (J:133566)
• mice have higher tolerance to glucose challenge after being fed a high-fat diet compared to controls (J:133566)
• mice fed a high fat diet higher drops in blood sugar upon insulin challenge compared to wild-type mice fed the same diet (J:133566)
• mice have a lower score than controls on the homeostasis model assessment measure of insulin sensitivity (J:133566)
• mice fed a high fat diet higher drops in blood sugar upon insulin challenge compared to wild-type mice fed the same diet (J:133566)
• mice have a lower score than controls on the homeostasis model assessment measure of insulin sensitivity (J:133566)
• mice fed a high-fat diet have higher serum levels of adiponectin (J:133566)
• mice fed a high-fat diet have higher serum levels of adiponectin (J:133566)




Genotype
MGI:3574535
hm2
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells (J:95641)
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells (J:95641)
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen (J:95641)
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen (J:95641)

hematopoietic system
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells (J:95641)
• stimulation with intact antibodies to IgM induced proliferation in mutant but not wild-type B cells (J:95641)
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen (J:95641)
• IgM levels are lower in mutants without stimulation and after stimulation with a T dependent antigen (J:95641)




Genotype
MGI:3574536
cx3
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Genetic
Background
B6.129-Dok1tm1Yyam Dok2tm1Yyam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• double homozygotes develop myeloproliferative disease by about 1 year of age with atypical myeloid cells resembling myelomonocytic cells (J:95335)
• cellular infiltrations of granulocytes and lymphocytes are seen in several tissues (J:95335)
• double homozygotes develop myeloproliferative disease by about 1 year of age with atypical myeloid cells resembling myelomonocytic cells (J:95335)
• cellular infiltrations of granulocytes and lymphocytes are seen in several tissues (J:95335)
• about half of the double homozygotes with myeloproliferative disease develop histiocytic sarcoma of macrophage origin (J:95335)
• about half of the double homozygotes with myeloproliferative disease develop histiocytic sarcoma of macrophage origin (J:95335)

hematopoietic system
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors (J:95335)
• hyperplasia of myeloid precursors (J:95335)
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors (J:95335)
• hyperplasia of myeloid precursors (J:95335)
• hyperplasia of megakaryocytes (J:95335)
• hyperplasia of megakaryocytes (J:95335)
• hyperplasia of erythroblasts (J:95335)
• hyperplasia of erythroblasts (J:95335)
• leukocyte numbers in the peripheral blood are significantly higher (J:95335)
• leukocyte numbers in the peripheral blood are significantly higher (J:95335)
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate (J:95335)
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate (J:95335)
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines (J:95335)
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines (J:95335)

immune system
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors (J:95335)
• hyperplasia of myeloid precursors (J:95335)
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors (J:95335)
• hyperplasia of myeloid precursors (J:95335)
• leukocyte numbers in the peripheral blood are significantly higher (J:95335)
• leukocyte numbers in the peripheral blood are significantly higher (J:95335)
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate (J:95335)
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate (J:95335)
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines (J:95335)
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines (J:95335)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Chronic Myeloid; CML 608232 J:95335




Genotype
MGI:4829895
cx4
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type (J:163407)
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type (J:163407)

hematopoietic system
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type (J:163407)
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type (J:163407)




Genotype
MGI:4829896
cx5
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (3 available)
Dok3tm1Brs mutation (0 available); any Dok3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• nearly half (15 of 33) of the mice died between 14?51 weeks after birth (J:163407)
• nearly half (15 of 33) of the mice died between 14?51 weeks after birth (J:163407)

tumorigenesis
• a markedly high incidence (24 of 41) of large cell tumors at 65 weeks of age (J:163407)
• a markedly high incidence (24 of 41) of large cell tumors at 65 weeks of age (J:163407)
• abnormal proliferative cells with histiocytic morphology and cell surface markers in the bone marrow, spleen, and/or liver (J:163407)
• the histiocytic sarcoma is highly invasive and transplantable (J:163407)
• abnormal proliferative cells with histiocytic morphology and cell surface markers in the bone marrow, spleen, and/or liver (J:163407)
• the histiocytic sarcoma is highly invasive and transplantable (J:163407)

hematopoietic system
• abnormal Mac-2-positive macrophages in the lung (J:163407)
• abnormal Mac-2-positive macrophages in the lung (J:163407)
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response (J:163407)
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response (J:163407)

immune system
• abnormal Mac-2-positive macrophages in the lung (J:163407)
• abnormal Mac-2-positive macrophages in the lung (J:163407)
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response (J:163407)
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response (J:163407)




Genotype
MGI:3804060
cx6
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Ppargtm1Laz/Ppargtm1Laz
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
Ppargtm1Laz mutation (1 available); any Pparg mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
N
• the characteristic resistance of Dok1tm1Yyam homozygotes to a high fat diet in terms of weight gain, adipose tissue growth, and rises in serum levels of leptin and insulin are normalized when mice are on a Pparg homozygote background (J:133566)
• the characteristic resistance of Dok1tm1Yyam homozygotes to a high fat diet in terms of weight gain, adipose tissue growth, and rises in serum levels of leptin and insulin are normalized when mice are on a Pparg homozygote background (J:133566)
• size of adipocytes is smaller compared to wild-type controls when a high-fat diet (J:133566)
• size of adipocytes is smaller compared to wild-type controls when a high-fat diet (J:133566)




Genotype
MGI:3574537
cx7
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Tg(BCR/ABL1)5Hhi/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
Tg(BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age (J:95335)
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age (J:95335)

tumorigenesis
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts (J:95335)
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts (J:95335)

immune system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)

hematopoietic system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)

endocrine/exocrine glands
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Chronic Myeloid; CML 608232 J:95335




Genotype
MGI:3574538
cx8
Allelic
Composition
Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(BCR/ABL1)5Hhi/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (1 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (3 available)
Tg(BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age (J:95335)
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age (J:95335)

tumorigenesis
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts (J:95335)
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts (J:95335)

immune system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)

hematopoietic system
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)

endocrine/exocrine glands
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age (J:95335)

Mouse Models of Human Disease
OMIM ID Ref(s)
Leukemia, Chronic Myeloid; CML 608232 J:95335





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory