Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation
(0 available);
any
Dok2 mutation
(16 available)
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immune system
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• activation of granulocytes by TPA is impaired but no increase in spontaneous infections is seen
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neoplasm
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• at 11-25 months, 24% of mice develop lung adenocarcinoma compared with 7% of wild-type mice
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hematopoietic system
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• activation of granulocytes by TPA is impaired but no increase in spontaneous infections is seen
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respiratory system
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• at 11-25 months, 24% of mice develop lung adenocarcinoma compared with 7% of wild-type mice
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Allelic Composition |
Dok2tm1Ppp/Dok2+
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Genetic Background |
129S1/Sv-Dok2tm1Ppp |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation
(0 available);
any
Dok2 mutation
(16 available)
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neoplasm
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• at 15 to 19 months, 4 of 12 mice develop lung tumors unlike wild-type mice
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respiratory system
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• at 15 to 19 months, 4 of 12 mice develop lung tumors unlike wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation
(0 available);
any
Dok1 mutation
(19 available)
Dok2tm1Ppp mutation
(0 available);
any
Dok2 mutation
(16 available)
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neoplasm
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• double homozygotes develop chronic myeloid leukemia-like myeloproliferative disease at 10-12 months of age
• this myeloproliferative disease is fully transplantable
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• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma
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hematopoietic system
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• bone marrow hypercellularity and infiltration by myeloid cells that retain the ability to terminally differentiate are seen
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• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
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• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors
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immune system
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• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
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• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors
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respiratory system
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• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma
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growth/size/body
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation
(0 available);
any
Dok1 mutation
(19 available)
Dok2tm1Ppp mutation
(0 available);
any
Dok2 mutation
(16 available)
Dok3tm1Ppp mutation
(0 available);
any
Dok3 mutation
(18 available)
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mortality/aging
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• mice begin to die at around 1 year of age unlike wild-type mice
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respiratory system
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• mice exhibit an increase in the total number of lung cells compared with wild-type mice
• however, lung weight is normal
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• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice
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• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice
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• the number and percentages of bronchioalveolar stem cells are increased compared to in wild-type mice
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• at 12 weeks, mice exhibit alveolar hyperplasia with scattered bronchioaveolar stem cells unlike in wild-type mice
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• the number and percentages of alveolar type 2 cells are increased compared to in wild-type mice
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neoplasm
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• at 20 months, mice exhibit an expansion of Mac-1+ and GR-1+ Mac-1+ cells compared with wild-type mice
• however, Mac-1+ and GR-1+ Mac-1+ cell numbers are normal at 3 months
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• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice
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• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice
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immune system
hematopoietic system
growth/size/body
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• mice exhibit an increase in the total number of lung cells compared with wild-type mice
• however, lung weight is normal
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation
(0 available);
any
Dok2 mutation
(16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation
(0 available)
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mortality/aging
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• loss of Dok2 shortened lifespan to about 270 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2
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neoplasm
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• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation
(0 available);
any
Dok2 mutation
(16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation
(0 available)
|
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mortality/aging
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• loss of Dok2 shortened lifespan to about 283 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2
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neoplasm
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• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase
• acceleration was not as severe as in homozygous null mice
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