About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Igh-V186.2-TCL1A)3Cro
transgene insertion 3, Carlo M Croce
MGI:3527221
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Igh-ROR1)1Kip/0
Tg(Igh-V186.2-TCL1A)3Cro/0
B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro MGI:5571374
cx2
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0
Tg(Igh-V186.2-TCL1A)3Cro/0
involves: C3H * C57BL/6 * FVB/N MGI:4820822
tg3
Tg(Igh-V186.2-TCL1A)3Cro/0 B6.Cg-Tg(Igh-V186.2-TCL1A)3Cro MGI:5571378
tg4
Tg(Igh-V186.2-TCL1A)3Cro/0 involves: C3H * C57BL/6 MGI:3841692


Genotype
MGI:5571374
cx1
Allelic
Composition
Tg(Igh-ROR1)1Kip/0
Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic
Background
B6.Cg-Tg(Igh-ROR1)1Kip Tg(Igh-V186.2-TCL1A)3Cro
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

neoplasm
• develop leukemia at a younger median age than mice with either transgene alone
• expansion of CD5+B220low B cells is accelerated and mice show earlier development of leukemia compared to single Tg(Igh-ROR1)1Kip mice

mortality/aging
• median survival is 50.6 weeks

hematopoietic system
• develop CD5+B220low B-cell lymphocytosis at a younger median age than mice with either transgene alone
• double mutants show an increase in percentage of CD5+B220low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice

immune system
• develop CD5+B220low B-cell lymphocytosis at a younger median age than mice with either transgene alone
• double mutants show an increase in percentage of CD5+B220low B cells among blood lymphocytes compared to single Tg(Igh-V186.2-TCL1A)3Cro mice




Genotype
MGI:4820822
cx2
Allelic
Composition
Tg(Igh-Mir29a,-Mir29b-1,-hrGFP)#Cro/0
Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic
Background
involves: C3H * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone

hematopoietic system
• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone
• increased number of CD5+ B cells in spleen

immune system
• 3-fold increases in spleen weight compared to Tg(Igh-V186.2-TCL1A)3Cro mice alone
• increased number of CD5+ B cells in spleen

neoplasm
• a significant increased number of CD5+CD19+ and CD5+IgM+ B-cell populations compared with Tg(Igh-V186.2-TCL1A)3Cro mice alone




Genotype
MGI:5571378
tg3
Allelic
Composition
Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic
Background
B6.Cg-Tg(Igh-V186.2-TCL1A)3Cro
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 57.7 weeks

neoplasm
• develop chronic lymphocytic leukemia-like disease




Genotype
MGI:3841692
tg4
Allelic
Composition
Tg(Igh-V186.2-TCL1A)3Cro/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• livers are enlarged after the onset of leukemia
• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age
• spleen weight increases to 20-fold or higher than controls after the onset of leukemia

immune system
• cellularity in the peritoneal cavity is increased 50- to 100- fold compared to controls due to presence of large B1b B-cell population
• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age
• spleen weight increases to 20-fold or higher than controls after the onset of leukemia
• an abnormal CD5+ CD11b+ population is found in all transgenic mice
• this B cell population makes up 44% of cells in the peritoneal cavity of 2-month old mice, 8.6% of splenocytes by 4 months of age, 43% of bone marrow cells by 8 months of age
• increased numbers of B cells are found in the marginal zone with a CD21loCD5+ phenotype

neoplasm
• clonality of cells is observed in the CD5+ B cell population in mice over 7 months of age
• these cells have low proliferative activity, which is a characteristic of leukemia cells
• mice 13-18 months of age become visibly ill, have enlarged liver, spleens, and lymph nodes, and have white blood cell counts that are 50-fold higher than normal
• blood of these older mice contain large lymphoid cells, smeared cells, and lymphocytes with clumped nuclear chromatin

digestive/alimentary system
• cellularity in the peritoneal cavity is increased 50- to 100- fold compared to controls due to presence of large B1b B-cell population

liver/biliary system
• livers are enlarged after the onset of leukemia

hematopoietic system
• spleens are enlarged 1.5-fold compared to controls in mice under 1 year of age
• spleen weight increases to 20-fold or higher than controls after the onset of leukemia
• an abnormal CD5+ CD11b+ population is found in all transgenic mice
• this B cell population makes up 44% of cells in the peritoneal cavity of 2-month old mice, 8.6% of splenocytes by 4 months of age, 43% of bone marrow cells by 8 months of age
• increased numbers of B cells are found in the marginal zone with a CD21loCD5+ phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/28/2022
MGI 6.20
The Jackson Laboratory