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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd276tm1Wwh
targeted mutation 1, Wayne W Hancock
MGI:3527215
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd276tm1Wwh/Cd276tm1Wwh B6.Cg-B7h3tm1Wwh MGI:3527895


Genotype
MGI:3527895
hm1
Allelic
Composition
Cd276tm1Wwh/Cd276tm1Wwh
Genetic
Background
B6.Cg-B7h3tm1Wwh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd276tm1Wwh mutation (0 available); any Cd276 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• cyclosporin A and rapamycin treatment result in decreased expression of IL-2, IFNG, and decreased expression of chemokines CCL2 and CXCL10 in engrafted homozygotes compared to similarly treated wild-type mice
• about 50% of homozygotes given a subtherapeutic regimen of cyclosporin A survive over 30 days longer after transplantation of hearts from BALB/c donors unlike wild-type mice which survive only 1-2 days longer with cyclosporin A treatment
• rapamycin therapy led to permanent cardiac allograft engraftment and in about 70% of homozygotes permanent islet allograft engraftment, unlike in wild-type mice where rapamycin treatment resulted in a maximum increase in survival of 12 days (cardiac) or 2 weeks (islet)
• homozygous mutants that receive cardiac allografts with CD154 mAb treatment survive indefinitely while wild-type mice display end-stage rejection at 50 days post-transplant
• in a model of MHC class II disparity homozygotes do not display severe transplant arteriosclerosis or interstitial fibrosis unlike wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory