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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ctsktm1Vuo
targeted mutation 1, Eero Vuorio
MGI:3527195
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ctsktm1Vuo/Ctsktm1Vuo involves: 129S7/SvEvBrd * C57BL/6J MGI:3527897


Genotype
MGI:3527897
hm1
Allelic
Composition
Ctsktm1Vuo/Ctsktm1Vuo
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsktm1Vuo mutation (0 available); any Ctsk mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• the osteoclast surface area is doubled
• the number of osteoclasts and osteoclast precursors are increased
• total and trabecular bone mineral density are increased at 2 months of age; however, this difference decreases with age
• trabecular bone volume and thickness and trabecular number are increased and trabecular separation is decreased in homozygotes
• in the metaphyseal and diaphyseal region of the femur and tibia cartical thickness is increased at 2 months of age but does not increase more with age

hematopoietic system
• the osteoclast surface area is doubled
• the number of osteoclasts and osteoclast precursors are increased

immune system
• the osteoclast surface area is doubled
• the number of osteoclasts and osteoclast precursors are increased





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory