Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation
(1 available);
any
Flt1 mutation
(73 available)
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normal phenotype
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• almost all homozygous embryos survive
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation
(1 available);
any
Flt1 mutation
(73 available)
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mortality/aging
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• about 50% of homozygotes die around E9.5; the other half survive and develop normally
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cardiovascular system
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• increased endothelial cell apoptosis is seen
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• poor blood vessel formation is seen in about 50% of homozygous embryos
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• the dorsal aorta in growth retarded embryos is smaller than norma
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embryo
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• about 50% of embryos fail to turn by E8.5
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• about 50% of embryos display growth arrest before E8.5
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Allelic
Composition |
Flt1tm2Msh/Flt1+
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Genetic
Background |
involves: 129S/SvEv * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation
(1 available);
any
Flt1 mutation
(73 available)
|
|
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embryo
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• about 50% of embryos show developmental defects similar to those in homozygous mice
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mortality/aging
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• about 90% of mutants die as embryos
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cardiovascular system
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• differentiation of vascular endothelial cells is disturbed
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo
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cellular
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• differentiation of vascular endothelial cells is disturbed
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo
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mortality/aging
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• all of the double homozygotes die as embryos
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cardiovascular system
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo
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cellular
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• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo
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Analysis Tools