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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cybanmf333
neuroscience mutagenesis facility 333
MGI:3526726
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cybanmf333/Cybanmf333 A.B6 Tyr+-Cybanmf333/J MGI:3526727
hm2
Cybanmf333/Cybanmf333 involves: A * C57BL/6 MGI:5569388


Genotype
MGI:3526727
hm1
Allelic
Composition
Cybanmf333/Cybanmf333
Genetic
Background
A.B6 Tyr+-Cybanmf333/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cybanmf333 mutation (1 available); any Cyba mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit a body tilt
• mutant mice are unable to remain at the surface of the water in a forced swim test whereas control mice are good swimmers
• head- and body tilt can be observed at approximately 4 weeks of age with average onset 4.6 +/- 0.6 weeks (J:82238)

hearing/vestibular/ear
N
• hearing is unaffected in mutant mice as assessed by ABR analysis
• otoconia are absent in the utricle and saccule of newborn mutant mice
• encephalographs indicate that mutant mice are nonresponsive even at maximum accelerations

immune system
• mutant neutrophils do not produce superoxide in either the presence or absence of PMA, in contrast to controls
• Nox activity is completely absent from mutant neutrophils
• at 3.5 days post-infection with 104 CFU of Burkholderia cepacia, spleen derived from mutant mice contain necrotic areas and increased numbers of polymorphonuclear cells within the marginal zone and the red pulp
• at 3.5 days post-infection with 104 CFU of Burkholderia cepacia, mutant lung tissue is damaged by necrotizing pneumonia and alveolar spaces are filled with granulocytes, macrophages and cell debris
• mutant animals innoculated intratrachially with 106 CFU of Burkholderia cepacia succumb to the infection within 3 days of infection with animals dying within 24 hours of the first signs of respiratory distress
• defective bacterial clearance in mutant mice is shown in lung homogenates; at 3.5 days post-infection with 104 CFU of Burkholderia cepacia, mutant lung homogenates contain more than 108 CFU of bacteria, while lung homogenates from control littermates do not contain any bacteria
• at 3.5 days post-infection with 104 CFU of Burkholderia cepacia, mutant spleen contains large numbers of Burkholderia cepacia, whereas controls do not

respiratory system
• at 3.5 days post-infection with 104 CFU of Burkholderia cepacia, mutant lung tissue is damaged by necrotizing pneumonia and alveolar spaces are filled with granulocytes, macrophages and cell debris

hematopoietic system
• mutant neutrophils do not produce superoxide in either the presence or absence of PMA, in contrast to controls
• Nox activity is completely absent from mutant neutrophils




Genotype
MGI:5569388
hm2
Allelic
Composition
Cybanmf333/Cybanmf333
Genetic
Background
involves: A * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cybanmf333 mutation (1 available); any Cyba mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• goblet cells exhibit increased mucin accumulation compared with control cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory