Phenotypes associated with this allele

• Allele Symbol: Rdh11^tm1Tsyk
• Allele Name: targeted mutation 1, Tom S Y Kim
• Allele ID: MGI:3526658
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rdh11^tm1Tsyk/Rdh11^tm1Tsyk	involves: 129S1/Sv * 129X1/SvJ	MGI:3578358
cx2	Rdh11^tm1Tsyk/Rdh11^tm1Tsyk Rdh5^tm1Drie/Rdh5^tm1Drie	involves: 129S1/Sv * 129X1/SvJ	MGI:3578359

Genotype
MGI:3578358

hm1

• Allelic Composition: Rdh11^tm1Tsyk/Rdh11^tm1Tsyk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

delayed dark adaptation ( J:97788 )

• slightly delayed dark adaptation and decreased 11-cis-retinal levels following exposure to intense bleaching conditions (500 cd/m² for 3 minutes)

• not as delayed as the mice lacking both Rdh11 and Rdh5 or mice homozygous for Rdh5^tm1Drie alone

• no abnormalities in retinal morphology are seen

reproductive system

reproductive system phenotype ( J:97788 )

N • fertility and testes morphology are normal

Genotype
MGI:3578359

cx2

• Allelic Composition: Rdh11^tm1Tsyk/Rdh11^tm1Tsyk; Rdh5^tm1Drie/Rdh5^tm1Drie
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

vision/eye

abnormal eye electrophysiology ( J:97788 )

• slightly reduced a- and b-wave amplitude responses are seen under dark adapted conditions

delayed dark adaptation ( J:97788 )

• delayed dark adaptation and decreased 11-cis-retinal levels following exposure to intense bleaching conditions (500 cd/m² for 3 minutes)

• more severely delayed than in either single homozygote