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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spred1tm1Hiin
targeted mutation 1, Hiromasa Inoue
MGI:3526452
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spred1tm1Hiin/Spred1tm1Hiin B6.Cg-Spred1tm1Hiin MGI:3836813
hm2
Spred1tm1Hiin/Spred1tm1Hiin involves: C57BL/6 MGI:3526849


Genotype
MGI:3836813
hm1
Allelic
Composition
Spred1tm1Hiin/Spred1tm1Hiin
Genetic
Background
B6.Cg-Spred1tm1Hiin
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spred1tm1Hiin mutation (1 available); any Spred1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite abnormal CNS transmission, mice exhibit normal dendritic arborization
• the slope of field excitatory postsynaptic potentials is decreased compared to in wild-type mice
• following a single theta burst stimulation
• following a train of low-frequency stimulation
• at 10 and 20 ms interpulse intervals

behavior/neurological
• in a T-maze, mice exhibit reduced visual discrimination compared to wild-type mice
• in a hidden-platform Morris water maze assay, mice perform worse than wild-type mice in the second week
• however, motivation and sensory-motor abilities are normal
• mice spend less time in the target quadrant than wild-type mice in a Morris water maze when the platform is removed
• mice swim slower and float more than wild-type mice




Genotype
MGI:3526849
hm2
Allelic
Composition
Spred1tm1Hiin/Spred1tm1Hiin
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spred1tm1Hiin mutation (1 available); any Spred1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• mutants have a shortened face

growth/size/body
• mutants have a shortened face

hematopoietic system
• increased eosinophilia is seen in the airways of mutants during OVA-induced asthma
• injection of IL-5 induced a greater and longer lasting increase in peripheral eosinophil counts
• eosinophil chemotaxis towards eotaxin is increased

immune system
• increased eosinophilia is seen in the airways of mutants during OVA-induced asthma
• injection of IL-5 induced a greater and longer lasting increase in peripheral eosinophil counts
• eosinophil chemotaxis towards eotaxin is increased
• after challenge with OVA the concentrations of IL-13 and eotaxin are increased

limbs/digits/tail

respiratory system
• in an induced asthma model mutants display enhanced airway responsiveness





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory