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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt9btm1Amc
targeted mutation 1, Andrew P McMahon
MGI:3526436
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Wnt9btm1Amc/Wnt9btm1Amc involves: 129X1/SvJ MGI:3589876
ht2
 		Wnt9btm1Amc/Wnt9btm1.1Amc involves: 129X1/SvJ * C57BL/6 * CBA MGI:3589875
cn3
 		Pbx1tm1Mlc/Pbx1+
Wnt9btm1Amc/Wnt9btm1Amc
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ MGI:5305933
cn4
 		Wnt9btm1Amc/Wnt9btm1Amc
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129X1/SvJ MGI:5305932


Genotype
MGI:3589876
hm1
Allelic
Composition		 Wnt9btm1Amc/Wnt9btm1Amc
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9btm1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151498 )
• all mice die within 1 months of birth

renal/urinary system
kidney cyst ( J:151498 )
• cystic tubules
• pronounced cysts by P1
abnormal kidney collecting duct epithelium morphology ( J:151498 )
• collecting duct epithelial cells exhibit randomized elongation unlike in wild-type mice
small kidney ( J:100575 )
• small kidneys with few mature nephrons are seen
abnormal renal tubule morphology ( J:151498 )
• severely dilated and cystic tubules
• kidney tubule diameter is decreased at E15.5, E17.5 and P1
dilated renal tubule ( J:151498 )
• as early as E15.5
• severe
• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct

growth/size/body
kidney cyst ( J:151498 )
• cystic tubules
• pronounced cysts by P1
renal glomerulus cyst ( J:151498 )




Genotype
MGI:3589875
ht2
Allelic
Composition		 Wnt9btm1Amc/Wnt9btm1.1Amc
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (22 available)
Wnt9btm1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
small kidney ( J:100575 )
• small kidneys with few mature nephrons are seen




Genotype
MGI:5305933
cn3
Allelic
Composition		 Pbx1tm1Mlc/Pbx1+
Wnt9btm1Amc/Wnt9btm1Amc
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Pbx1tm1Mlc mutation (0 available); any Pbx1 mutation (40 available)
Wnt9btm1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip in all mice

digestive/alimentary system

growth/size/body
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip in all mice
cleft palate ( J:178316 )




Genotype
MGI:5305932
cn4
Allelic
Composition		 Wnt9btm1Amc/Wnt9btm1Amc
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Wnt9btm1Amc mutation (0 available); any Wnt9b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip in all mice

digestive/alimentary system

growth/size/body
bilateral cleft upper lip ( J:178316 )
• bilateral cleft lip in all mice
cleft palate ( J:178316 )




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory