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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Iqgap2tm1Vs
targeted mutation 1, Valentina A Schmidt
MGI:3526416
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Iqgap2tm1Vs/Iqgap2tm1Vs either: 129S4/SvJae-Iqgap2tm1Vs or B6.129S4-Iqgap2tm1Vs MGI:3777246
hm2
Iqgap2tm1Vs/Iqgap2tm1Vs involves: 129S4/SvJae MGI:5568837
cx3
Iqgap1tm1Aber/Iqgap1tm1Aber
Iqgap2tm1Vs/Iqgap2tm1Vs
involves: 129S4/SvJae MGI:3777247


Genotype
MGI:3777246
hm1
Allelic
Composition
Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic
Background
either: 129S4/SvJae-Iqgap2tm1Vs or B6.129S4-Iqgap2tm1Vs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqgap2tm1Vs mutation (1 available); any Iqgap2 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• progressive increase in death rate with age
• separation of survival curve from that of controls is first significant at 200 days after birth

liver/biliary system
• at 8 and 12 months, edematous mitochondrial matrix is seen in liver cells but not in skeletal muscle cells
• gradual and progressive increase in apoptosis at 4 and 8 months of age
• significant hepatocyte loss by 8 months of age
• develops in mice over 12 months of age
• at 18 - 24 months of age 86% of mice had hepatocellular carcinomas
• associated with an increase in Iqgap1 expression

neoplasm
• develops in mice over 12 months of age
• at 18 - 24 months of age 86% of mice had hepatocellular carcinomas
• associated with an increase in Iqgap1 expression
• occasional uterine hemangiomas are detected

homeostasis/metabolism
• at 8 months of age
• however, bilirubin, alanine aminotransferase, and creatine phosphokinase levels are not different from wild-type controls at 8 months of age

cellular
• at 8 and 12 months, edematous mitochondrial matrix is seen in liver cells but not in skeletal muscle cells
• gradual and progressive increase in apoptosis at 4 and 8 months of age




Genotype
MGI:5568837
hm2
Allelic
Composition
Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqgap2tm1Vs mutation (1 available); any Iqgap2 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop hepatocellular carcinoma that recapitulates molecular features of advanced human hepatocellular carcinoma

liver/biliary system
• mice develop hepatocellular carcinoma that recapitulates molecular features of advanced human hepatocellular carcinoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:205882




Genotype
MGI:3777247
cx3
Allelic
Composition
Iqgap1tm1Aber/Iqgap1tm1Aber
Iqgap2tm1Vs/Iqgap2tm1Vs
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqgap1tm1Aber mutation (1 available); any Iqgap1 mutation (102 available)
Iqgap2tm1Vs mutation (1 available); any Iqgap2 mutation (84 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• incidence is decreased compared to Iqgap1tm1Vs single homozygotes but is increased compared to controls

mortality/aging
N
• unlike Iqgap1tm1Vs single homozygotes, survival durations are not significantly different from controls

neoplasm
• incidence is decreased compared to Iqgap1tm1Vs single homozygotes but is increased compared to controls
• when present hepatocellular carcinomas are smaller than those in Iqgap1tm1Vs single homozygotes

homeostasis/metabolism
N
• unlike Iqgap2tm1Vs single homozygotes, levels of aspartate transaminase are similar to controls in mice at 4 and 8 months of age





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory