All Phenotypes Agxt<tm1Ull> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Agxt^tm1Ull
targeted mutation 1, Eduardo C Salido
MGI:3526219

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agxt^tm1Ull/Agxt^tm1Ull	B6.129X1-Agxt^tm1Ull	MGI:3717654
hm2	Agxt^tm1Ull/Agxt^tm1Ull	involves: 129X1/SvJ * C57BL/6	MGI:5314652
hm3	Agxt^tm1Ull/Agxt^tm1Ull	involves: 129X1/SvJ * C57BL/6J	MGI:6472964
cx4	Agxt^tm1Ull/Agxt^tm1Ull Prodh2^em1Jkni/Prodh2^em1Jkni	involves: 129X1/SvJ * C57BL/6J	MGI:6472960

Allelic Composition	Agxt^tm1Ull/Agxt^tm1Ull
Genetic Background	B6.129X1-Agxt^tm1Ull

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agxt^tm1Ull mutation (0 available); any Agxt mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

hyperoxaluria ( J:117145 )

• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype

• urine oxalate levels increase in male mice treatment with ethylene glycol

crystalluria ( J:117145 )

• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice

nephrocalcinosis ( J:117145 )

• neprhocalcinosis develops in male mice after treatment with ethylene glycol

urolithiasis ( J:117145 )

• at 6 months, 62 of 112 male mice have stones in their urinary bladder

decreased creatinine clearance ( J:117145 )

• creatinine clearance is reduced in male mice treatment with ethylene glycol

kidney failure ( J:117145 )

• renal failure develops in male mice after treatment with ethylene glycol

homeostasis/metabolism

hyperoxaluria ( J:117145 )

• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype

• urine oxalate levels increase in male mice treatment with ethylene glycol

crystalluria ( J:117145 )

• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary hyperoxaluria type 1		DOID:0111670	OMIM:259900	J:117145

Allelic Composition	Agxt^tm1Ull/Agxt^tm1Ull
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agxt^tm1Ull mutation (0 available); any Agxt mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

nephrocalcinosis ( J:181969 )

• some male mice fed a diet with 1% hydroxyproline exhibit mild nephrocalcinosis compared with wild-type mice

homeostasis/metabolism

increased physiological sensitivity to xenobiotic ( J:181969 )

• some male mice fed a diet with 1% hydroxyproline exhibit mild nephrocalcinosis compared with wild-type mice

Allelic Composition	Agxt^tm1Ull/Agxt^tm1Ull
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agxt^tm1Ull mutation (0 available); any Agxt mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperoxaluria ( J:283585 )

• both males and females exhibit an increase in urinary oxalate excretion, with males excreting 2-fold more urinary oxalate than females

renal/urinary system

hyperoxaluria ( J:283585 )

• both males and females exhibit an increase in urinary oxalate excretion, with males excreting 2-fold more urinary oxalate than females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
primary hyperoxaluria type 1		DOID:0111670	OMIM:259900	J:283585

Allelic Composition	Agxt^tm1Ull/Agxt^tm1Ull Prodh2^em1Jkni/Prodh2^em1Jkni
Genetic Background	involves: 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agxt^tm1Ull mutation (0 available); any Agxt mutation (16 available)
Prodh2^em1Jkni mutation (0 available); any Prodh2 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal urine homeostasis ( J:283585 )

• mice show lowered urinary glycolate levels compared to single Agxt homozygotes

hyperoxaluria ( J:283585 )

• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Agxt homozygotes

renal/urinary system

abnormal urine homeostasis ( J:283585 )

• mice show lowered urinary glycolate levels compared to single Agxt homozygotes

hyperoxaluria ( J:283585 )

• mice show increased urinary oxalate excretion compared to wild-type mice but reduced excretion compared to single Agxt homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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