renal/urinary system
crystalluria
(
J:117145
)
|
• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice
|
|
• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype
• urine oxalate levels increase in male mice treatment with ethylene glycol
|
|
• neprhocalcinosis develops in male mice after treatment with ethylene glycol
|
urolithiasis
(
J:117145
)
|
• at 6 months, 62 of 112 male mice have stones in their urinary bladder
|
|
• creatinine clearance is reduced in male mice treatment with ethylene glycol
|
|
• renal failure develops in male mice after treatment with ethylene glycol
|
homeostasis/metabolism
crystalluria
(
J:117145
)
|
• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice
|
|
• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype
• urine oxalate levels increase in male mice treatment with ethylene glycol
|
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Hyperoxaluria, Primary, Type I; HP1 | 259900 | J:117145 | |