Mouse Genome Informatics
hm1
    Agxttm1Ull/Agxttm1Ull
B6.129X1-Agxttm1Ull
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice
• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype
• urine oxalate levels increase in male mice treatment with ethylene glycol
• neprhocalcinosis develops in male mice after treatment with ethylene glycol
• at 6 months, 62 of 112 male mice have stones in their urinary bladder
• creatinine clearance is reduced in male mice treatment with ethylene glycol
• renal failure develops in male mice after treatment with ethylene glycol

homeostasis/metabolism
• calcium oxalate crystals are found in the urine where as none are detected in wild-type mice
• mice are hyperoxaluric compared to controls with males showing a higher urinary oxalate concentration than females at the same genotype
• urine oxalate levels increase in male mice treatment with ethylene glycol

Mouse Models of Human Disease
OMIM IDRef(s)
Hyperoxaluria, Primary, Type I; HP1 259900 J:117145


Mouse Genome Informatics
hm2
    Agxttm1Ull/Agxttm1Ull
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• some male mice fed a diet with 1% hydroxyproline exhibit mild nephrocalcinosis compared with wild-type mice

homeostasis/metabolism
• some male mice fed a diet with 1% hydroxyproline exhibit mild nephrocalcinosis compared with wild-type mice