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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dusp6tm1Sms
targeted mutation 1, Suzanne L Mansour
MGI:3526178
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dusp6tm1Sms/Dusp6tm1Sms involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3697387
ht2
Dusp6tm1Sms/Dusp6+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3697388


Genotype
MGI:3697387
hm1
Allelic
Composition
Dusp6tm1Sms/Dusp6tm1Sms
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp6tm1Sms mutation (0 available); any Dusp6 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected are found at weaning
• Background Sensitivity: with further crosses to C57BL/6 mice the number of mutants found at weaning decreases

growth/size/body
• about 40% of P5 - P16 homozygotes have a body weight that is less than 75% of their littermate average
• however, mice with reduced body weight are not normally found at weaning

skeleton
• at P10 the skull vault height to length and height to width ratios are increased in small mice only
• variable abnormalities of the middle ear bones in some small mice
• at P14 small mice have severely reduced ossification zones in the proximal tibia
• at P14 small mice have severely reduced hypertrophic zones with disorganized chondrocytes in the proximal tibia
• coronal craniosynostosis at P5-15 in small mice only
• a slight delay in the ossification sequence of the phalanges is seen in small mice
• however, no obvious hand or foot malformations are seen

hearing/vestibular/ear
• variable abnormalities of the middle ear bones in some small mice
• variable abnormalities of the otic capsule in some small mice
• unilateral or bilateral elevation in auditory brainstem responses were seen in 1 of 2 small mice that survived to P21-28

craniofacial
• at P10 the skull vault height to length and height to width ratios are increased in small mice only
• variable abnormalities of the middle ear bones in some small mice




Genotype
MGI:3697388
ht2
Allelic
Composition
Dusp6tm1Sms/Dusp6+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dusp6tm1Sms mutation (0 available); any Dusp6 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected are found at weaning
• Background Sensitivity: with further crosses to C57BL/6 mice the number of mutants found at weaning decreases

skeleton
• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice
• variable abnormalities of the middle ear bones in some small mice
• coronal craniosynostosis at P5-15 in small mice only and not in small or normal sized wild-type mice

hearing/vestibular/ear
• variable abnormalities of the middle ear bones in some small mice
• variable abnormalities of the otic capsule in some small mice
• unilateral or bilateral elevation in auditory brainstem responses were seen in 3 of 3 small mice that survived to P21-28

craniofacial
• at P10 the skull vault height to length and height to width ratios are increased in small mice only and not in small or normal sized wild-type mice
• variable abnormalities of the middle ear bones in some small mice





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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory