All Phenotypes Sycp2<tm1Jw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sycp2^tm1Jw
targeted mutation 1, Jeremy Wang
MGI:3526164

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sycp2^tm1Jw/Sycp2^tm1Jw	involves: 129S4/SvJae * C57BL/6	MGI:3687460

Allelic Composition	Sycp2^tm1Jw/Sycp2^tm1Jw
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sycp2^tm1Jw mutation (0 available); any Sycp2 mutation (84 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Meiotic arrest and apoptosis of spermatocytes in Sycp2^tm1Jw/Sycp2^tm1Jw mice

reproductive system

increased male germ cell apoptosis ( J:111287 )

• increased apoptosis of spermatocytes

abnormal gametogenesis ( J:111287 )

azoospermia ( J:111287 )

• no postmeiotic germ cells

• epididymal tubules are empty at 8 weeks of age

abnormal female meiosis ( J:111287 )

• homologous chromosome alignments but full synapsis is interrupted

arrest of male meiosis ( J:111287 )

• complete meiotic arrest

• spermatocytes develop to zygotene stage but fail to continue to pachytene

• failure of chromosome synapsis, axial elements fail to form

• spermatocytes undergo apoptosis

abnormal male reproductive system morphology ( J:111287 )

abnormal testis morphology ( J:111287 )

small seminiferous tubules ( J:111287 )

• significantly smaller in diameter

decreased testis weight ( J:111287 )

• testis weight 70% less than controls

abnormal fertility/fecundity ( J:111287 )

reduced female fertility ( J:111287 )

decreased litter size ( J:111287 )

• average litter size for females of 4.4 pups as opposed to 7.8 pups in controls

male infertility ( J:111287 )

endocrine/exocrine glands

abnormal testis morphology ( J:111287 )

small seminiferous tubules ( J:111287 )

• significantly smaller in diameter

decreased testis weight ( J:111287 )

• testis weight 70% less than controls

cellular

azoospermia ( J:111287 )

• no postmeiotic germ cells

• epididymal tubules are empty at 8 weeks of age

increased male germ cell apoptosis ( J:111287 )

• increased apoptosis of spermatocytes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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