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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hoxd1tm1Mrc
targeted mutation 1, Mario R Capecchi
MGI:3526155
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hoxd1tm1Mrc/Hoxd1tm1Mrc involves: 129 MGI:4947861


Genotype
MGI:4947861
hm1
Allelic
Composition
Hoxd1tm1Mrc/Hoxd1tm1Mrc
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd1tm1Mrc mutation (0 available); any Hoxd1 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit prolonged carrageenan-induced thermal allodynia compared with similarly treated wild-type mice
• mice exhibit longer latency to extremely cold surface compared with wild-type mice

nervous system
• mice exhibit abnormal nociceptor innervation of the skin compared with wild-type mice
• mice exhibit reduced peripherin+ axonal endings associated with hair follicles compared with wild-type mice
• mice exhibit a large number of aberrant nociceptor axonal projections in the spinal cord compared with wild-type mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory