nervous system
N |
• in mutant mice, basal synaptic transmission and short-term synaptic plasticity, measured by recording fEPSPs and PPF, is similar to controls
• conventional theta burst stimulation (TBS) induces robust and stable LTP in Schaffer collateral CA1 synapses, similar to controls
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• in mutant mice, nicotine does not induce nor promote the spread of excitatory neural activity from the Schaffer collateral pathway as measured by fEPSPs and optical fluorescence
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• in mutant mice, nicotine does not promote the spread of inhibitory neural activity from the temporoammonic pathway as measured by fEPSPs and optical fluorescence
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• in Schaffer collateral CA1 synapses, nicotine induced facilitation of theta-burst stimulated LTP induction is supressed
• in temporoammonic CA1 synapses, nicotine supression of LTP induction is eliminated
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homeostasis/metabolism
• in mutant mice, nicotine fails to facilitate LTP in the Schaffer collateral pathway and fails to supress LTP induction in the temporoammonic pathway
• nicotine fails to induce and promote the spread of excitatory activity in the Schaffer collateral pathway and fails to supress inhibitory activity in the temporoammonic pathway
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