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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Chrna2tm1Jbou
targeted mutation 1, Jim Boulter
MGI:3526149
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Chrna2tm1Jbou/Chrna2tm1Jbou B6.129X1-Chrna2tm1Jbou MGI:3790875


Genotype
MGI:3790875
hm1
Allelic
Composition
Chrna2tm1Jbou/Chrna2tm1Jbou
Genetic
Background
B6.129X1-Chrna2tm1Jbou
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna2tm1Jbou mutation (1 available); any Chrna2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• in mutant mice, basal synaptic transmission and short-term synaptic plasticity, measured by recording fEPSPs and PPF, is similar to controls
• conventional theta burst stimulation (TBS) induces robust and stable LTP in Schaffer collateral CA1 synapses, similar to controls
• in mutant mice, nicotine does not induce nor promote the spread of excitatory neural activity from the Schaffer collateral pathway as measured by fEPSPs and optical fluorescence
• in mutant mice, nicotine does not promote the spread of inhibitory neural activity from the temporoammonic pathway as measured by fEPSPs and optical fluorescence
• in Schaffer collateral CA1 synapses, nicotine induced facilitation of theta-burst stimulated LTP induction is supressed
• in temporoammonic CA1 synapses, nicotine supression of LTP induction is eliminated

homeostasis/metabolism
• in mutant mice, nicotine fails to facilitate LTP in the Schaffer collateral pathway and fails to supress LTP induction in the temporoammonic pathway
• nicotine fails to induce and promote the spread of excitatory activity in the Schaffer collateral pathway and fails to supress inhibitory activity in the temporoammonic pathway





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory