All Phenotypes Kat5<tm1Jwl> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kat5^tm1Jwl
targeted mutation 1, John W Lough
MGI:3526095

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat5^tm1Jwl/Kat5^tm1Jwl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3814375
cx2	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0 Trp53^tm1Tyj/Trp53⁺	involves: 129 * C57BL * C57BL/6 * SJL	MGI:3814381
cx3	Kat5^tm1Jwl/Kat5⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3814378
cx4	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0	involves: 129S1/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL	MGI:3814376
cx5	Cdkn2a^tm1Cjs/Cdkn2a⁺ Kat5^tm1Jwl/Kat5⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3814377

Allelic Composition	Kat5^tm1Jwl/Kat5^tm1Jwl
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation ( J:125164 )

Allelic Composition	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0 Trp53^tm1Tyj/Trp53⁺
Genetic Background	involves: 129 * C57BL * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (25 available)
Tg(IghMyc)22Bri mutation (1 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125164 )

• mice die prior to 20 weeks of age

neoplasm

increased B cell derived lymphoma incidence ( J:125164 )

• mice exhibit an earlier age of onset and enhanced penetrance of B cell lymphomas compared to in Tg(IghMyc)22Bri mice

Allelic Composition	Kat5^tm1Jwl/Kat5⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (25 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:125164 )

• mice exhibit the same disease progression as in Trp53^tm1Tyj homozygotes

Allelic Composition	Kat5^tm1Jwl/Kat5⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (25 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:125164 )

• mice die prior to 30 weeks of age

neoplasm

increased B cell derived lymphoma incidence ( J:125164 )

• mice exhibit an earlier age of onset and enhanced penetrance of B cell lymphomas compared to in Tg(IghMyc)22Bri mice

• tumor cells exhibit replacement of the knock-out allele with a wild-type allele

immune system

abnormal B cell physiology ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

homeostasis/metabolism

abnormal DNA repair ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

• however, DNA damage repair following ionizing radiation exposure is normal

cellular

abnormal DNA repair ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

• however, DNA damage repair following ionizing radiation exposure is normal

hematopoietic system

abnormal B cell physiology ( J:125164 )

• B cells exhibit severely impaired Myc-induced DNA damage repair

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a⁺ Kat5^tm1Jwl/Kat5⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Kat5^tm1Jwl mutation (0 available); any Kat5 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor latency ( J:125164 )

• mice exhibit the same early tumor onset as in Cdkn2a^tm1Cjs homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23