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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MMTV-cre)7Mul
transgene insertion 7, William J Muller
MGI:3525443
Summary 18 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Cdh1tm2Kem/Cdh1+
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)7Mul/0
involves: 129 * C57BL/6 * FVB/N MGI:5634403
cn2
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)7Mul/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N MGI:5634404
cn3
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Pten+
Tg(MMTV-cre)7Mul/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N MGI:4839508
cn4
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N MGI:4839510
cn5
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N MGI:5314779
cn6
Srctm1Mul/Src+
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5314777
cn7
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5314778
cn8
Erbb2tm8(Erbb2)Mul/Erbb2+
Tg(MMTV-cre)7Mul/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3714371
cn9
Sfntm1Mul/Sfntm1Mul
Tg(MMTV-cre)7Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4452139
cn10
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5314776
cn11
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0
involves: 129S4/SvJae * FVB/N MGI:4839512
cn12
Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
involves: 129S4/SvJaeSor * FVB/N MGI:3615264
cn13
Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
involves: 129S4/SvJaeSor * FVB/N MGI:3615265
cn14
Erbb3tm1Squ/Erbb3tm1Squ
Tg(MMTV-cre)7Mul/0
involves: 129S6/SvEvTac * FVB/N MGI:3691287
cn15
Itgb1tm1Mll/Itgb1tm1Mll
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)634Mul/0
involves: 129X1/SvJ * FVB/N MGI:3704008
cn16
Itgb1tm1Mll/Itgb1tm1Mll
Tg(MMTV-cre)7Mul/0
involves: 129X1/SvJ * FVB/N MGI:3704007
cn17
Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor+
Tg(MMTV-cre)7Mul/0
involves: BALB/c * FVB/N MGI:5052139
cn18
Dock1tm2.1Jfco/Dock1tm2.1Jfco
Tg(MMTV-cre)7Mul/0
involves: C57BL/6 * FVB/N * FVB/NJ MGI:5515764


Genotype
MGI:5634403
cn1
Allelic
Composition
Cdh1tm2Kem/Cdh1+
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm2Kem mutation (1 available); any Cdh1 mutation (118 available)
Smad4tm2.1Cxd mutation (1 available); any Smad4 mutation (12 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Trp53tm1Brn mutation (8 available); any Trp53 mutation (136 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age
• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen

endocrine/exocrine glands
• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age
• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen

neoplasm
• mice develop mammary gland carcinoma with a median tumor-free survival of 10.4 months of age
• tumors are invasive ductal carcinomas with a squamous component, however lobular carcinomas are not seen
• 33% of mice show lung metastasis




Genotype
MGI:5634404
cn2
Allelic
Composition
Smad4tm2.1Cxd/Smad4tm2.1Cxd
Trp53tm1Brn/Trp53tm1Brn
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm2.1Cxd mutation (1 available); any Smad4 mutation (12 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Trp53tm1Brn mutation (8 available); any Trp53 mutation (136 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mice develop mammary gland carcinoma with a median tumor-free survival of 12.1 months of age

endocrine/exocrine glands
• mice develop mammary gland carcinoma with a median tumor-free survival of 12.1 months of age

neoplasm
• mice develop mammary gland carcinoma with a median tumor-free survival of 12.1 months of age
• 35.7% of mice show lung metastasis




Genotype
MGI:4839508
cn3
Allelic
Composition
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Pten+
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm8(Erbb2)Mul mutation (0 available); any Erbb2 mutation (3 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (34 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer

endocrine/exocrine glands
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer

neoplasm
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 6.5 compared with 15.3 months
• tumor progression is associated with loss of heterozygosity at the Pten locus in 50% of mutant mammary tumors
• tumors are similar to basal-like subtype of human breast cancer
• 35% incidence of lung metastases compared with 5% in single Erbb2 mutants

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:133305




Genotype
MGI:4839510
cn4
Allelic
Composition
Erbb2tm8(Erbb2)Mul/Erbb2+
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm8(Erbb2)Mul mutation (0 available); any Erbb2 mutation (3 available)
Ptentm1Hwu mutation (3 available); any Pten mutation (34 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer

endocrine/exocrine glands
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer

neoplasm
• mammary tumor onset is accelerated in virgin females compared with either single Pten or single Erbb2 mutants, with tumor latencies of 2.4 compared with 15.5 months
• 25% of tumors are adenomyoepitheliomas
• 25% of tumors are Erbb2 type neoplasms
• 25% of tumors exhibit squamous metaplasia and retention of myoepithelium
• 25% of tumors are glandular, composed of distinctive large cell population that are a signature phenotype of mammary tumors in these mice
• tumors are similar to HER2 and basal-like subtype of human breast cancer

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:133305




Genotype
MGI:5314779
cn5
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (407 available)
Srctm1Mul mutation (0 available); any Src mutation (121 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice exhibit the same incidence of lung metastases and average metastatic burden as in Tg(MMTV-PyVT)#Mul mice




Genotype
MGI:5314777
cn6
Allelic
Composition
Srctm1Mul/Src+
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation (0 available); any Src mutation (121 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Analysis of tumorigenesis

integument
• with later onset than in Tg(MMTV-PyVT)#Mul mice

endocrine/exocrine glands
• with later onset than in Tg(MMTV-PyVT)#Mul mice

neoplasm
• with later onset than in Tg(MMTV-PyVT)#Mul mice




Genotype
MGI:5314778
cn7
Allelic
Composition
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation (0 available); any Src mutation (121 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Analysis of tumorigenesis

integument
• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice

endocrine/exocrine glands
• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice

neoplasm
• with later onset and decreased tumor burden than in Tg(MMTV-PyVT)#Mul mice




Genotype
MGI:3714371
cn8
Allelic
Composition
Erbb2tm8(Erbb2)Mul/Erbb2+
Tg(MMTV-cre)7Mul/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm8(Erbb2)Mul mutation (0 available); any Erbb2 mutation (3 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• numerous lobular side buds with acinar structures are observed
• mice develop precocious lobualveolar hyperplasias of the mammary glands
• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

neoplasm
• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

integument
• numerous lobular side buds with acinar structures are observed
• mice develop precocious lobualveolar hyperplasias of the mammary glands
• virgin female mutants develop mammary tumors with an average latency of 15.9 months with >90% affected by 2 years of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
J:167180




Genotype
MGI:4452139
cn9
Allelic
Composition
Sfntm1Mul/Sfntm1Mul
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfntm1Mul mutation (0 available); any Sfn mutation (11 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• unaffected mammary ductal outgrowth
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell
• unaffected rate of apoptotic cell death in mammary epithelial cells
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells
• dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells

cellular
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell

integument
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• unaffected mammary ductal outgrowth
• threefold increase in the proliferative capacity of the luminal mammary epithelial cell
• unaffected rate of apoptotic cell death in mammary epithelial cells
• disrupted epithelial cell junctions at both the basal and apical layers shown by ZO-1 and E-Cadherin staining of isolated mammary epithelial cells in transwell monolayer cultures
• decreased percentage of polarized epithelial cells
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells
• dramatically reduced percentage of polarized cysts compared with wild-type controls in 3D Matrigel cultures
• multiple layers of CK8-positive luminal cells contained within a single layer of CK14-positive myoepithelial cells in virgin mammary glands derived from mutant animals
• isolated mammary epithelial cells in 3D Matrigel cultures form filled lumens with depolarized epithelial growth, compared with the highly polarized acini derived from control cells




Genotype
MGI:5314776
cn10
Allelic
Composition
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srctm1Mul mutation (0 available); any Src mutation (121 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Normal mammary gland branching and ductal outgrowth in Srctm1Mul/Srctm1Mul Tg(MMTV-cre)7Mul/0 mice

reproductive system
N
• mice exhibit normal mammary gland branching and ductal outgrowth




Genotype
MGI:4839512
cn11
Allelic
Composition
Ptentm1Hwu/Ptentm1Hwu
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Hwu mutation (3 available); any Pten mutation (34 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice do not develop mammary tumors over a 16 month period




Genotype
MGI:3615264
cn12
Allelic
Composition
Ets2tm3Rgo/Ets2tm3Rgo
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
Genetic
Background
involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (2 available); any Meox2 mutation (4 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

integument
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

neoplasm
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:3615265
cn13
Allelic
Composition
Ets2tm3Rgo/Ets2+
Meox2tm1(cre)Sor/?
Tg(MMTV-cre)7Mul/?
Genetic
Background
involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm3Rgo mutation (1 available); any Ets2 mutation (6 available)
Meox2tm1(cre)Sor mutation (2 available); any Meox2 mutation (4 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

endocrine/exocrine glands
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis

neoplasm
• onset of mammary tumors with a median onset of 132 days
• this mutant was used as control for Ets2tm3Rgo/Ets2tm3.1Rgo Meox2tm1(cre)Sor /? Tg(MMTV-PyVT*Y315F,Y322F)Db-1Mul/? mice to test the effect of Ets2 deficiency on mammary tumrigenesis




Genotype
MGI:3691287
cn14
Allelic
Composition
Erbb3tm1Squ/Erbb3tm1Squ
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3tm1Squ mutation (0 available); any Erbb3 mutation (8 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• ductal density is lower in 4-8 week-old virgin females
• there are fewer end branches and terminal buds in mammary gland ductal system

integument
• ductal density is lower in 4-8 week-old virgin females
• there are fewer end branches and terminal buds in mammary gland ductal system




Genotype
MGI:3704008
cn15
Allelic
Composition
Itgb1tm1Mll/Itgb1tm1Mll
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Mll mutation (1 available); any Itgb1 mutation (12 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• mammary tumors are not detected at 10 weeks of age, like they are in control mice expressing Tg(MMTV-PyVT)634Mul
• although palpable mammary tumors are detected after 4 months of age, these tumors are composed of cells which fail to express the cre transgene and thus express Itgb1

endocrine/exocrine glands
• mammary tumors are not detected at 10 weeks of age, like they are in control mice expressing Tg(MMTV-PyVT)634Mul
• although palpable mammary tumors are detected after 4 months of age, these tumors are composed of cells which fail to express the cre transgene and thus express Itgb1

neoplasm
• mammary tumors are not detected at 10 weeks of age, like they are in control mice expressing Tg(MMTV-PyVT)634Mul
• although palpable mammary tumors are detected after 4 months of age, these tumors are composed of cells which fail to express the cre transgene and thus express Itgb1




Genotype
MGI:3704007
cn16
Allelic
Composition
Itgb1tm1Mll/Itgb1tm1Mll
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb1tm1Mll mutation (1 available); any Itgb1 mutation (12 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• mice with ablation of Itgb1 in the mammary epithelium show normal mammary ductual outgrowth during puberty and are able to lactate and produce viable litters through multiple rounds of pregnancy




Genotype
MGI:5052139
cn17
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj/Gt(ROSA)26Sor+
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: BALB/c * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-PIK3CA*H1047R,-EGFP)Balj mutation (0 available); any Gt(ROSA)26Sor mutation (407 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice
• mammary tumors are heterogeneous (adenomyoepitheliomas)

endocrine/exocrine glands
• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice
• mammary tumors are heterogeneous (adenomyoepitheliomas)

mortality/aging
• 75% of mice die before 4 months of age

neoplasm
• in 25% of mice after 214 days unlike Tg(MMTV-cre)7Mul mice
• mammary tumors are heterogeneous (adenomyoepitheliomas)




Genotype
MGI:5515764
cn18
Allelic
Composition
Dock1tm2.1Jfco/Dock1tm2.1Jfco
Tg(MMTV-cre)7Mul/0
Genetic
Background
involves: C57BL/6 * FVB/N * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock1tm2.1Jfco mutation (0 available); any Dock1 mutation (15 available)
Tg(MMTV-cre)7Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• mice exhibit normal mammary gland development and are capable of nursing their offspring to maturity





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory