Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation
(10 available);
any
Gt(ROSA)26Sor mutation
(942 available)
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Nubp2tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Nubp2 mutation
(17 available)
Tg(Wnt1-GAL4)11Rth mutation
(2 available)
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embryo
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• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5
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cellular
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• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5
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pigmentation
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• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region
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integument
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• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region
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pigmentation
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• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region
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integument
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• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region
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pigmentation
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• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region
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integument
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• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region
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pigmentation
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N |
• at P21, mice do not show white patches of fur on the ventral region of their torso or any other region
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mortality/aging
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• mice are embryonic lethal
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mortality/aging
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• although mice are able to survive to adulthood, their survival rate is lower than expected
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growth/size/body
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• at P21, mice show significantly decreased body weight relative to control mice
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pigmentation
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• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region
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integument
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• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region
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craniofacial
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N |
• at P21, mice exhibit no obvious defects in the craniofacial region
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Nubp2tm1c(EUCOMM)Hmgu mutation
(0 available);
any
Nubp2 mutation
(17 available)
Tg(Wnt1-GAL4)11Rth mutation
(2 available)
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craniofacial
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• undersized facial primordia at E10.5
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• olfactory epithelium is continuous with the oral cavity
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growth/size/body
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• undersized facial primordia at E10.5
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• olfactory epithelium is continuous with the oral cavity
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• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice
• however, there is no difference in centriole number
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embryo
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• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice
• however, there is no difference in centriole number
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digestive/alimentary system
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• olfactory epithelium is continuous with the oral cavity
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nervous system
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• brain is shifted rostrally
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respiratory system
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• olfactory epithelium is continuous with the oral cavity
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skeleton
taste/olfaction
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• olfactory epithelium is continuous with the oral cavity
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pigmentation
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N |
• at P21, mice do not show white patches of fur on the ventral region of their torso or any other region
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Tg(Wnt1-GAL4)11Rth mutation
(2 available)
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behavior/neurological
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• males spend more time in the center of the open field than wild-type males; no differences are observed with females of either genotype
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• in the Morris water maze probe test, females show significant impairment relative to controls; males show no difference
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• males spend more time in the open center of the elevated plus maze compared to wild-type males; no differences are observed in female mutants or controls
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• males and females exhibit significantly increased locomotor activity
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• mice show less nest building behavior than wild-type during a 3 day observation period
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• mutant males show decreased social interactions relative to wild-type with lower total number and duration of interactions with unfamiliar mice; females show no significant differences from wild-type
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nervous system
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• cholinergic and glutamatergic fibers from the medial habenula nucleus are disordered in males and females; immunolabeling shows irregular tracts in the interpeduncular nucleus
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Analysis Tools