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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Wnt1-GAL4)11Rth
transgene insertion 11, David H Rowitch
MGI:3524966
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Nubp2tm1c(EUCOMM)Hmgu/Nubp2tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J MGI:6452819
cn2
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267026
cn3
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267027
cn4
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267030
cn5
Ywhaetm2.1Awb/Ywhaetm2.1Awb
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267034
cn6
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267035
cn7
Ywhaetm2.1Awb/Ywhae+
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267036
cn8
Nubp2tm1c(EUCOMM)Hmgu/Nubp2tm1c(EUCOMM)Hmgu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
involves: C57BL/6 MGI:6450919
cx9
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: 129S6/SvEvTac * C57BL/6J MGI:6267037
cx10
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
involves: C57BL/6J * CBA/J * Swiss albino MGI:5551395


Genotype
MGI:6452819
cn1
Allelic
Composition
Nubp2tm1c(EUCOMM)Hmgu/Nubp2tm1c(EUCOMM)Hmgu
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm4(ACTB-tdTomato,-EGFP)Luo mutation (9 available); any Gt(ROSA)26Sor mutation (745 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Nubp2tm1c(EUCOMM)Hmgu mutation (0 available); any Nubp2 mutation (10 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5

cellular
• reduced +GFP craniofacial neural crest cells in nasal prominences and pharyngeal arches due to increased apoptosis between E9.5 and E10.5




Genotype
MGI:6267026
cn2
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (63 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are embryonic lethal




Genotype
MGI:6267027
cn3
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (63 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• although mice are able to survive to adulthood, their survival rate is lower than expected

growth/size/body
• at P21, mice show significantly decreased body weight relative to control mice

pigmentation
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 1.09 cm2
• however, no white patches were observed on the tail and paws or any other region

craniofacial
N
• at P21, mice exhibit no obvious defects in the craniofacial region




Genotype
MGI:6267030
cn4
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (63 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 88.5 % of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.69 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267034
cn5
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 80.0% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.23 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267035
cn6
Allelic
Composition
Ywhaetm2.1Awb/Ywhaetm2.1Awb
YwhazGt(OST432062)Lex/Ywhaz+
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (63 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region

integument
• at P21, 100% of mice show white patches of fur on the ventral region of their torso; the area of white patches is 0.97 cm2
• however, no white patches were observed on the tail and paws or any other region




Genotype
MGI:6267036
cn7
Allelic
Composition
Ywhaetm2.1Awb/Ywhae+
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
Ywhaetm2.1Awb mutation (1 available); any Ywhae mutation (63 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• at P21, mice do not show white patches of fur on the ventral region of their torso or any other region




Genotype
MGI:6450919
cn8
Allelic
Composition
Nubp2tm1c(EUCOMM)Hmgu/Nubp2tm1c(EUCOMM)Hmgu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Nubp2tm1c(EUCOMM)Hmgu mutation (0 available); any Nubp2 mutation (10 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• undersized facial primordia at E10.5
• olfactory epithelium is continuous with the oral cavity

growth/size/body
• undersized facial primordia at E10.5
• olfactory epithelium is continuous with the oral cavity
• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice
• however, there is no difference in centriole number

embryo
• craniofacial mesenchyme exhibit a slight increase in average cilia per cell compared with control mice
• however, there is no difference in centriole number

digestive/alimentary system
• olfactory epithelium is continuous with the oral cavity

nervous system
• brain is shifted rostrally

respiratory system
• olfactory epithelium is continuous with the oral cavity

skeleton

taste/olfaction
• olfactory epithelium is continuous with the oral cavity




Genotype
MGI:6267037
cx9
Allelic
Composition
YwhazGt(OST432062)Lex/YwhazGt(OST432062)Lex
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
YwhazGt(OST432062)Lex mutation (3 available); any Ywhaz mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
N
• at P21, mice do not show white patches of fur on the ventral region of their torso or any other region




Genotype
MGI:5551395
cx10
Allelic
Composition
H2az2Tg(Wnt1-cre)11Rth/0
Tg(Wnt1-GAL4)11Rth/0
Genetic
Background
involves: C57BL/6J * CBA/J * Swiss albino
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tg(Wnt1-GAL4)11Rth mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• males spend more time in the center of the open field than wild-type males; no differences are observed with females of either genotype
• in the Morris water maze probe test, females show significant impairment relative to controls; males show no difference
• males spend more time in the open center of the elevated plus maze compared to wild-type males; no differences are observed in female mutants or controls
• males and females exhibit significantly increased locomotor activity
• mice show less nest building behavior than wild-type during a 3 day observation period
• mutant males show decreased social interactions relative to wild-type with lower total number and duration of interactions with unfamiliar mice; females show no significant differences from wild-type

nervous system
• cholinergic and glutamatergic fibers from the medial habenula nucleus are disordered in males and females; immunolabeling shows irregular tracts in the interpeduncular nucleus





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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory